Combination of Ondansetron and Droperidol in the Prophylaxis of Postoperative Nausea and Vomiting

Evaluation of the Effective Drugs for the Prevention of Nausea and Vomiting Induced by Morphine Used for Postoperative Pain: A Quantitative Systematic Review

“…The test drug was droperidol in 11 studies, 7,8,12,[16][17][18][19][20][21] metoclopramide in 5 studies, 9,10,16,21) dexamethasone in 6 studies, [22][23][24] propofol in 4 studies, [25][26][27][28] and ondansetron in 5 studies. 9,12,15,22) The results of testing the lack of homogeneity the results of studies for each of the four test drugs are shown. Droperidol: Q＝15.77 (df＝10), p＝0.15; Metoclopramide: Q＝2.63 (df＝4), p＝0.15; Dexamethasone: Q ＝ 4.23 (df ＝ 5), p ＝ 0.65; and Propofol: Q＝1.62 (df＝3), p＝0.81.…”

RETRACTED ARTICLE: Current prevention and treatment of postoperative nausea and vomiting with 5-hydroxytryptamine type 3 receptor antagonists: a review

“…immediately after the induction of anesthesia was superior to that of droperidol alone for the prevention of PONV in women having tubal banding. In patients undergoing abdominal surgery, ondansetron 4 mg plus droperidol 2.5 mg was more effective than either antiemetic alone for the control of PONV [75]. Similarly, the granisetron/ droperidol combination improves the antiemetic effect.…”

Low Doses of Haloperidol Combined With Ondansetron Are not Effective for Prophylaxis of Postoperative Nausea and Vomiting in Susceptible Patients

“…In the O&Hal1 group, 42% (CI: 32-53) of patients suffered from EE vs 20% (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29), 25% (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) and 30% in groups O&Dex, O&Hal2 and O&Dro respectively (P=.005). These significant differences were observed in groups O&Dex and O&Hal1 from the 6 to 12 h interval ( Table 2).…”

“…[22][23][24][25] Droperidol was the most frequently used antiemetic around the world, 26 and, since the FDA alert, the use of haloperidol has increased. Evidence of its antiemetic effect has existed since the 1970s and it possesses a longer half-life than droperidol (12-36 h vs 2.5 h).…”