Combination of Oral Antidiabetic Agents with Basal Insulin Versus Premixed Insulin Alone in Randomized Elderly Patients with Type 2 Diabetes Mellitus

Janka, H. U.; Plewe, G.; Busch, Klaus

doi:10.1111/j.1532-5415.2007.01043.x

Cited by 77 publications

(47 citation statements)

References 16 publications

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“…16 In the clinical trials after 24 weeks of initiating basal insulin therapy, the proportion of patients who achieved HbA1c < 7% was high (~50%). 8,9,14 In the studies in real world practice, the rates of type 2 diabetic patients on basal insulin who reached HbA1c < 7% were 17.1% in Japan 13 and 33.7% in other Asian countries. 12 However, the rate of overall hypoglycemia was high (~50%) in the randomized controlled trials of insulin glargine or other basal insulins in patients with T2DM with inadequate glycemic control to OAD.…”

Section: Discussionmentioning

confidence: 98%

Basal Insulin Initiation in Elderly Patients with Type 2 Diabetes in Taiwan: A Comparison with Younger Patients

Chien

Lee

Liu

et al. 2015

International Journal of Gerontology

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s u m m a r y Background: Basal insulin is a common therapy for insulin initiation in patients with type 2 diabetes mellitus (T2DM) uncontrolled with oral antidiabetic drugs (OAD). There is limited data for initiating basal insulin therapy in the elderly population in clinical practice. Methods: The aim of this study was to analyze 72 Taiwanese patients with T2DM on OAD with glycated hemoglobin (HbA1c) > 7% who received basal insulin therapy with insulin glargine for 24 weeks in clinical practice. The patients were divided into an older group (! 65 years, n ¼ 32) and younger group (< 65 years, n ¼ 40) for comparison purposes. Results: At baseline, the duration of diabetes was longer and the fasting plasma glucose (FPG) level was slightly lower in the older group versus the younger group. The number of OAD types was significantly reduced after initiation of basal insulin in both groups. After the 24-week treatment of insulin glargine, the HbA1c and the FPG were significantly reduced by 1.18% and 81.3 mg/dL, respectively, in the older group, and by 1.49% and 93.0 mg/dL, respectively, in the younger group, but did not differ statistically between the two groups. The mean daily insulin doses in both groups were similar. Body weight increased significantly but it was comparable in older and younger patients. The rate of hypoglycemic events was low and no difference was found between the two groups. Conclusion: In elderly people with T2DM in Taiwan who had inadequate glycemic control by OAD, initiation of basal insulin therapy with insulin glargine over 24 weeks provided effective glycemic control similar to the younger population.

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Section: Discussionmentioning

confidence: 98%

Basal Insulin Initiation in Elderly Patients with Type 2 Diabetes in Taiwan: A Comparison with Younger Patients

Chien

Lee

Liu

et al. 2015

International Journal of Gerontology

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“…54 Accordingly, analysis of data from 130 elderly patients (Ն65 years of age) with poorly controlled type 2 diabetes who participated in a 24-week, multicenter, open, parallel study demonstrated higher rates of hypoglycemia, especially nocturnal hypoglycemia, with premixed human insulin compared with insulin glargine plus OADs. 81 Inhaled insulin is a new treatment option that may be particularly useful in patients with an exaggerated fear of needles. 82 With an onset of action comparable to that observed with rapid-acting insulin analogs and duration of action similar to RHI, inhaled insulin may be a prandial insulin option in appropriate patients.…”

Section: Insulin Therapymentioning

confidence: 99%

Optimizing Insulin Use in Type 2 Diabetes: Role of Basal and Prandial Insulin in Long-Term Care Facilities

Haas

2007

Journal of the American Medical Directors Association

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“…In der LAPTOP-Studie profitierten besonders die älteren Patienten (>65 Jahre) von ihr. Den HbA1c-Zielwert von 7,0 erreichten 55 [20]. [42].…”

Section: "Basalunterstützt Orale Therapie" (Bot) Und "Supplementäre Iunclassified

Konventionelle und kombinierte Insulintherapie bei Typ-2-Diabetes

Janka

2006

Diabetologe

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Leitthema Nach epidemiologischen Daten spritzen 2% aller Deutschen und mehr als 5% aller Menschen über 70 Jahre Insulin [15]. Die nicht medikamentöse Diabetestherapie tendiert nach 10 Jahren Diabetesdauer gegen Null, gleichzeitig steigt die Insulintherapie mit zunehmender Diabetesdauer deutlich an (. Abb. 1) [27]. Der Typ-2-Diabetes manifestiert sich am häufigsten im Alter zwischen 55 und 65 Jahren. Die Indikation zur Insulintherapie bei Typ-2-Diabetes wird deshalb quantitativ ganz überwie-gend bei älteren Menschen gestellt. Für diesen Personenkreis muss die Behandlung möglichst einfach und praktikabel sein.

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Combination of Oral Antidiabetic Agents with Basal Insulin Versus Premixed Insulin Alone in Randomized Elderly Patients with Type 2 Diabetes Mellitus

Abstract: In elderly patients, addition of once-daily morning glargine+OAD is a simple regimen to initiate insulin therapy, restoring glycemic control more effectively and with less hypoglycemia than twice-daily 70/30 alone.

Cited by 77 publications

References 16 publications

Basal Insulin Initiation in Elderly Patients with Type 2 Diabetes in Taiwan: A Comparison with Younger Patients

Basal Insulin Initiation in Elderly Patients with Type 2 Diabetes in Taiwan: A Comparison with Younger Patients

Optimizing Insulin Use in Type 2 Diabetes: Role of Basal and Prandial Insulin in Long-Term Care Facilities

Konventionelle und kombinierte Insulintherapie bei Typ-2-Diabetes

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