Combination of oral vancomycin and intra-colonic vancomycin: Successful treatment of complicated pseudomembranous colitis in a child patient

Abstract

The Clostridium difficile infection–related disease varies from mild diarrhoea to pseudomembranouscolitis. Although C. difficile infection is commonly considered to be a hospital-acquired infection, a significant number of cases are community acquired. Community-acquired C. difficile infection can exhibit itself as ileus or toxic megacolon. Severe C. difficile infection that is unresponsive to intravenous metronidazole therapy requires more aggressive medical management and even surgical intervention. We present our case results for which vancomycin was administered both orally and intra-colonically. With this method, we treated the community acquired C. difficile infection patient who was presented as ileus.

Dual-Degradable Biohybrid Microgels by Direct Cross-Linking of Chitosan and Dextran Using Azide–Alkyne Cycloaddition

“…Especially, the dextran-based microgels are of great interest in developing colon-specific drug delivery microgels, , in which the drugs can be encapsulated and protected against hydrolysis from the stomach and small intestine, but can be triggered by an enzyme, Dextranase, and delivered when they enter into the colon region . Moreover, these microgels can be used for local therapies of the colonic diseases, such as Crohn’s disease, ulcerative colitis, pseudomembranous colitis, inflammatory bowel disease, and colorectal cancer . This will not only reduce the necessary drug dose but also lower the harmful adverse effects .…”