Abstract:Ovarian cancer affects one in 72 female patients in America, and nearly half of the females who carry a BRCA1/2 mutation will be diagnosed in their lifetime. At present, treatment options such as immune checkpoint inhibitors (ICI) and poly (ADP-ribose) polymerase inhibitors (PARPi) are effective against ovarian cancer in a subset of the population. In this article, we review important combination therapeutics that maximize the benefits of these agents in as many patients as possible. PARPi targets deoxyribonuc… Show more
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