Combination of Preoperative Haemoglobin and Albumin Levels and Lymphocyte and Platelet Counts (HALP) in Patients with Oesophageal Cancer

Topal, Uğur; Dal, Fatih; Sözüer, Erdoğan; Akyüz, Muhammet; Talih, Tutkun; Islam, Dogan Gurkan

doi:10.14260/jemds/2021/38

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…Furthermore, our results did not disclose a significant difference in disease recurrence. Nevertheless, according to our analysis, cancer-specific survival was found to be statically lower with lower HALP scores in comparison to the high HALP score group (p=0.001), which is consistent with published literature [7][8][9] . Moreover, after conducting a multivariate analysis, we divulged that age  65 years, right-sided tumor, surgical reintervention and lower HALP scores were independent prognostic factors in LACC and can be used to stratify patients' risk of poor outcome.…”

Section: Discussionsupporting

confidence: 92%

“…Furthermore, increased levels of platelets seem to lower the protection against tumor cytotoxicity leading to a dysfunctional systemic inflammatory response and, consequently, to rapid tumor growth and proliferation 3,4 . Current literature uncovers a few studies demonstrating how the combination of these four analytical parameters can predict patient's clinical prognosis in a variety of malignancies, including colon cancer, revealing to be a good prognostic index in patients with LACC [7][8][9][10] .…”

Section: Discussionmentioning

confidence: 99%

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Preoperative Halp Score as a Predictor of Survival in Locally Advanced Colon Cancer

Amado

Pimenta²,

Queirós³

et al. 2022

J Surg Cl Res

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Introduction: Lower preoperative hemoglobin (H), albumin (A), lymphocyte (L) and platelet (P) score (HALP) has been identified as a predictive factor in LACC to categorize patients with higher risk of poor outcome. Therefore, it is important to identify biomarkers available in clinical practice that can predict survival and patient’s prognosis. Our aim is to evaluate preoperative HALP score and its prognostic value. Materials and Methods: Our retrospective study included patients with LACC submitted to oncologic resection between January 2015 to December 2019 in our institution. LACC included stages II and III adenocarcinoma. HALP score was calculated as H (g/L) x A (g/L) x L (/L) / P (/L). A cutoff value was determined by ROC curve analysis and patients were divided accordingly into two groups (low and high HALP) to compare cancer-specific survival, through Kaplan-Meyer curve. Results: In our study, 127 patients were included. The mean age was 70,7 ± 11,9 years and 67 (52,8%) were male. Stage II incorporated 65 patients (51,2%) and stage III 62 (48,8%). The median follow-up time was 37 months. The HALP cutoff value estimated was 22,5. Age ³ 65 years, right-sided tumor, surgical reintervention and cancer-specific survival were associated with a lower HALP scores (p=0,002; p=0,004; p=0,008 and p=0.001, respectively). Conclusion: Nutritional and systemic inflammation status are extremely important in colon cancer prognosis. Serum biomarkers, such as HALP score could easily identify patients with a higher risk of poor outcome. Thus, this prognostic index may be useful as a clinical predictor of survival for LACC patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Preoperative Halp Score as a Predictor of Survival in Locally Advanced Colon Cancer

Amado

Pimenta²,

Queirós³

et al. 2022

J Surg Cl Res

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“…The HALP score consists of hemoglobin, albumin, lymphocyte and platelet values of patients and is an indicator of nutritional and systemic inflammation and can be used as a prognostic marker (15)(16)(17). Studies have found that it is associated with prognosis with many cancers such as colorectal cancers, bladder cancers, kidney cancers, pancreatic cancers, esophageal cancers, and small cell lung cancers (18)(19)(20)(21)(22)(23). However, its relationship with prognosis in patients older than 75 years with metastatic GC is unknown.…”

Section: Discussionmentioning

confidence: 99%

Yetmiş Beş Yaş Üstü Metastatik Mide Kanserli Hastalarda Hemoglobin, Albümin, Lenfosit, Platelet (HALP) Skoru ile Geriatrik Nütrisyonel İndeks (GNRI) ve Prognoz Arasındaki İlişki

Menekşe

Kut

2023

Batı Karadeniz Tıp Dergisi

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Aim: Gastric cancer (GC) is a common cancer with high mortality. Stage is the most important predictor of prognosis. But the clinical course of patients who are at the same stage may be different. Therefore, other prognostic markers other than stage are needed. Hemoglobin, albumin, lymphocyte and platelet (HALP) score and geriatric nutritional risk index (GNRI) related with prognosis in many malignancies, but their relationship to prognosis in patients with GC with advanced age is unknown. For this reason, we retrospectively analyzed patients older than 75 years, receiving chemotherapy, and metastatic GC. Material and Methods: We retrospectively analyzed 145 patients with metastatic gastric cancer, older than 75 years, receiving chemotherapy in secondary level state hospital between 2009 and 2022. Patients’ gender, age, Eastern Cooperative Oncology Group (ECOG) performance score, diagnosis dates, follow-up visits, albumin, hemoglobin, lactate dehydrogenase (LDH) levels, white blood cell, neutrophil, lymphocyte and platelet count, weight (kg), height (cm) values were examined. Using these values, HALP score, GNRI, and overall survival (OS) were calculated. Then, the relationship of these parameters with OS was analyzed retrospectively. Results: The median overall survival (OS) was 8.1 (95% Confidence interval (CI), 7.07 – 9.13) months. In multivariate analysis, GNRI (0.035) and HALP (p

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Is HALP score a predictor of poor prognosis in patients with hematologic malignancies admitted to the intensive care unit?

Sadri,

Tunay

2024

Egypt J Intern Med

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Background The Hemoglobin, Albumin, Lymphocyte, Platelet Score (HALP) is a novel predictive biomarker that has surfaced in the literature in recent years. It has been applied to the prediction of many clinical outcomes related to different neoplasms. Each of these inflammatory and nutritional markers is taken into account by the HALP score, which provides an overall prognosis for patients with cancer. Methods Retrospective data was collected on the demographics of patients hospitalized to our hospital's intensive care unit (ICU) for hematologic malignancies between January 2014 and March 2021. To measure the prognostic value of the HALP score, it was retrospectively calculated for patients with hematologic malignancies on the first day of ICU admission. This study looked into the link between the HALP score and general prognostic characteristics because it has been suggested that the HALP score is a relevant prognostic marker. Results Patients with an HALP score <37.10 had significantly higher APACHE II scores (p < 0.001). They also had significantly higher rates of qSOFA score ≥2 (89.3%), as well as statistically significantly higher rates of intubation (96%) and death (96.1%) (p < 0.001). Our study found that a HALP score <37.1 was associated with a 47.04-fold increase in mortality risk. Conclusion In patients with hematologic malignancies, the prognosis is strongly correlated with the HALP score. When validated in large cohorts, the HALP score, APACHE II, and q SOFA scores, either individually or collectively, can be used to guide prognostic evaluation of patients and act as a reliable predictor of unfavorable clinical outcomes in patients with hematologic malignancies.

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Combination of Preoperative Haemoglobin and Albumin Levels and Lymphocyte and Platelet Counts (HALP) in Patients with Oesophageal Cancer

Cited by 3 publications

References 27 publications

Preoperative Halp Score as a Predictor of Survival in Locally Advanced Colon Cancer

Preoperative Halp Score as a Predictor of Survival in Locally Advanced Colon Cancer

Yetmiş Beş Yaş Üstü Metastatik Mide Kanserli Hastalarda Hemoglobin, Albümin, Lenfosit, Platelet (HALP) Skoru ile Geriatrik Nütrisyonel İndeks (GNRI) ve Prognoz Arasındaki İlişki

Is HALP score a predictor of poor prognosis in patients with hematologic malignancies admitted to the intensive care unit?

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