Combination of ribose with calcium antagonist and β-blocker treatment in closed-chest rats

Zimmer, Heinz‐Gerd; Zierhut, Wolfgang; Marschner, G.

doi:10.1016/s0022-2828(87)80371-1

Cited by 19 publications

(5 citation statements)

References 14 publications

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“…Heart rate in control rats ranged from 345 to 392 beats/min. It is dependent on the kind and depth of anesthesia (31,38), on the age of the animals (31), as well as on the time of the day (3) and on the season in which the measurements are made (2). The range observed in this study agrees well with the heart rates of 320 to 385 beats/min, respectively, measured in awake rats (3,28).…”

Section: Acute Pulmonary Hypertensionsupporting

confidence: 81%

“…Two ultraminiature catheter pressure transducers were used. Model PR-249 (Millar Instruments, Inc., Houston, Texas) was applied for left heart catheterization, as described earlier (31,32,33,38). For right heart catheterization, the new model PR-291 was used.…”

Section: Methodsmentioning

confidence: 99%

“…Left ventricular function has been measured both in open-chest (5,20) and in closed-chest rats (31,32,36). In combination with the determination of cardiac output (14,16), left ventricular catheterization with the Millar ultraminiature catheter pressure transducer has become a routine method for the characterization of heart and circulatory function in intact small animals under control and various pathophysiologic conditions (38). In particular, several left ventricular hypertrophy models have been analyzed in hemodynamic and metabolic terms (33,37).…”

Section: Introductionmentioning

confidence: 99%

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Right heart catheterization in rats with pulmonary hypertension and right ventricular hypertrophy

et al. 1988

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Using a special Millar ultraminiature catheter pressure transducer, right ventricular functional parameters were measured in anesthetized, closed-chest rats under control conditions, during acute pulmonary hypertension and after induction of right ventricular hypertrophy. Acute i.v. infusion of noradrenaline and a brief period of hypoxia in female Sprague-Dawley rats elicited a marked increase in right ventricular systolic pressure (RVSP) and in the maximal rate of rise in right ventricular pressure (RV dp/dtmax). After 3 and 16 days of daily administrations of triiodothyronine in female Sprague-Dawley rats, all right ventricular hemodynamic parameters were enhanced along with the increase in left ventricular function. The right and left ventricles were hypertrophied, and cardiac output was increased. After 40 and 45 days subsequent to bilateral thorax irradiation of male Brown-Norway rats, RVSP and RV dp/dtmax were increased, the right ventricle was hypertrophied, while the left ventricle did not exhibit appreciable hemodynamic or morphologic alterations. Cardiac output was depressed. Thus, these two experimental models differ considerably as to the mechanism and time course of the development of right ventricular hypertrophy as well as to the participation of the left ventricle and the involvement of volume overload.

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Section: Acute Pulmonary Hypertensionsupporting

confidence: 81%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Right heart catheterization in rats with pulmonary hypertension and right ventricular hypertrophy

et al. 1988

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“…The effect of ribose administration has been assessed in several experimental models with depressed heart function associated with high energy phosphate loss [14,15,22,[32][33][34][35]. Administration of ribose increased the synthesis of adenine nucleotides and prevented the drop of cardiac function caused by isoproterenol infusion [14,15].…”

Section: Discussionmentioning

confidence: 99%

Ribose Treatment Reduced the Infarct Size and Improved Heart Function after Myocardial Infarction in Rats

Gónzalez¹,

Rabald

Briest

et al. 2009

Cell Physiol Biochem

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Objective: In this study the effect of ribose on heart function and infarct-size was analyzed 6 h after myocardial infarction (MI) in rats. Methods: Continuous i.v.-infusion of NaCl or ribose (200 mg/kg/h) was started one day prior to induction of MI in female Sprague-Dawley rats which was done by ligation of the left coronary artery. Six hours after MI heart function was measured with 3F tip catheter, cardiac output by thermodilution method. Thereafter the ischemic area was delineated by Evans Blue infusion, and the infarct area was visualized by triphenyltetrazolium chloride staining. The mRNA expression of interleukin (IL)-1β, IL-6, matrix-metalloproteinase (MMP)-8, and -9 was measured by ribonuclease protection assay. Results: Heart function was severely depressed 6 hours after coronary artery occlusion, but recovered significantly under the influence of ribose. Left ventricular (LV) systolic pressure (LVSP) and contractility (LVdP/dt_max) were restored to the normal levels of sham-operated animals, while parameters of LV relaxation (LVdP/dt_min and time constant of relaxation τ) were impaired compared to sham-operated animals, but significantly improved by ribose treatment compared to sham-treated MI-rats. Moreover, the infarct size was significantly smaller in the ribose treated animals despite a comparable ischemic area at risk in all MI-rats. The cytokine mRNA expression after MI was significantly reduced after ribose treatment, while there were no differences regarding MMP expression. Conclusion: MI size was significantly reduced and LV function significantly improved by ribose treatment at 6 h after MI. This seemed to be based on slowing the velocity of the necrotic wave front across the LV wall after MI resulting in smaller infarcts.

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“…This seems to be of general significance. Recently, we have shown that cardiac adenine nucleotide biosynthesis can be stimulated with ribose, when left heart function was depressed by the [3-receptor blocker metoprolol or by the calcium antagonist verapamil (31). Thus, calcium antagonists do not interfere with the stimulation of cardiac adenine nucleotide biosynthesis whether this occurs spontaneously as in the nonischemic myocardium or experimentally under the influence of ribose.…”

Section: Discussionmentioning

confidence: 99%

Myocardial infarction in rats: effects of metabolic and pharmacologic interventions

1989

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Myocardial infarction was induced in rats by ligation of the descending branch of the left coronary artery. The time course of changes in heart function was recorded within the first nine days. There was a progressive decline in LVSP, in LV dP/dtmax and in the pressure-rate-product. LVEDP was elevated. Cardiac output and stroke volume index were depressed after two days. The ATP content in the nonischemic region was lower than control, but recovered spontaneously toward the normal value within the first four days. Three metabolic and pharmacologic interventions known to affect cardiac adenine nucleotide metabolism were applied. Continuous i.v. administration of ribose which stimulates further adenine nucleotide biosynthesis attenuated the fall and promoted the restoration of ATP in the nonischemic myocardium within four days after coronary artery ligation. The elevation of LVEDP was attenuated with ribose after two and four days. The calcium antagonist gallopamil administered as i.v. infusion for two days led to a further reduction of all parameters of left heart function, but did not influence the increase in adenine nucleotide and protein synthesis that occurred in the nonischemic heart. Coenzyme Q10 had only slight effects on LVSP, LVEDP, and LV dP/dtmax, but attenuated significantly the fall in cardiac output and stroke volume index after two days following coronary artery ligation. Thus, all interventions affected differently the infarct-induced changes in heart and circulatory function. An improvement was observed with ribose and with coenzyme Q10.

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Combination of ribose with calcium antagonist and β-blocker treatment in closed-chest rats

Cited by 19 publications

References 14 publications

Right heart catheterization in rats with pulmonary hypertension and right ventricular hypertrophy

Right heart catheterization in rats with pulmonary hypertension and right ventricular hypertrophy

Ribose Treatment Reduced the Infarct Size and Improved Heart Function after Myocardial Infarction in Rats

Myocardial infarction in rats: effects of metabolic and pharmacologic interventions

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