Combination of <scp>NB‐UVB</scp> phototherapy and oral vitamin D supplementation in patients with generalized vitiligo: A randomized, triple‐blind, placebo‐controlled clinical trial

Garza‐Davila, Valeria F.; Valdespino‐Valdes, Jorge; Ramos, Abigail; Gonzalez‐Martínez, Gerardo; Herz‐Ruelas, Maira E.; Gomez‐Flores, Minerva; Ocampo‐Candiani, Jorge; Welsh‐Lozano, Oliverio; Cuellar‐Barboza, Adrian B.

doi:10.1111/jdv.19347

Acad Dermatol Venereol

2023

DOI: 10.1111/jdv.19347

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Combination of NB‐UVB phototherapy and oral vitamin D supplementation in patients with generalized vitiligo: A randomized, triple‐blind, placebo‐controlled clinical trial

Valeria F. Garza‐Davila,

Jorge Valdespino‐Valdes,

Abigail Ramos

et al.

Abstract: is a common depigmenting disorder with a worldwide prevalence of 0.5%-2%. 1 Narrowband-ultraviolet B (NB-UVB) phototherapy acts both in immunomodulation and stimulation of melanocyte activity. 2 Literature on vitamin D as an auxiliary treatment for vitiligo is limited. We evaluate the efficacy of Vitamin D3 supplementation with NB-UVB in vitiligo patients.After approval by our Institutional Ethics Review Board, we performed a randomized (1:1), triple-blind, placebocontrolled trial at the

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Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases

Joshi,

Hiremath,

John

et al. 2023

Pharmacol. Rep

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Disruption of the skin barrier and immunity has been associated with several skin diseases, namely atopic dermatitis (AD), psoriasis, and acne. Resident and non-resident immune cells and the barrier system of the skin are integral to innate immunity. Recent advances in understanding skin microbiota have opened the scope of further understanding the various communications between these microbiota and skin immune cells. Vitamins, being one of the important micronutrients, have been reported to exert antioxidant, anti-inflammatory, and anti-microbial effects. The immunomodulatory action of vitamins can halt the progression of skin diseases, and thus, understanding the immuno-pharmacology of these vitamins, especially for skin diseases can pave the way for their therapeutic potential. At the same time, molecular and cellular markers modulated with these vitamins and their derivatives need to be explored. The present review is focused on significant vitamins (vitamins A, B3, C, D, and E) consumed as nutritional supplements to discuss the outcomes and scope of studies related to skin immunity, health, and diseases. Graphical abstract

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Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases

Joshi,

Hiremath,

John

et al. 2023

Pharmacol. Rep

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Impact of Combined Phototherapy and Melanocyte Transplantation on Indicators of Vitiligo Activity

Wang,

Luo,

Zhao

et al. 2024

Dermatol Surg

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OBJECTIVE To investigate the effect of phototherapy combined with melanocyte transplantation on the activity index of vitiligo. METHODS One hundred twenty patients with stable vitiligo were selected and divided into 2 groups: phototherapy group (n = 60) and phototherapy combined with melanocyte therapy group (n = 60). Patients’ vitiligo activity scores before and 6 months after treatment, patients’ skin pigmentation responses 6 months after treatment, and patients’ new Koebner cases 6 months after treatment were compared. The expression of tyrosinase and Melan-A in the skin samples was analyzed by immunohistochemistry. RESULTS The effect of skin surface repigmentation in the observation group was better than that in the control group (p < .05). The expression of tyrosinase and Melan-A in the observation group was higher than that in the control group (p < .05), indicating that the combined treatment could enhance the function of melanocytes. After 6 months of treatment, the incidence of the Koebner phenomenon in the observation group was lower than that in the control group (p < .05). CONCLUSION The combination of phototherapy and melanocyte transplantation can obviously improve the activity index of vitiligo, slow down the spread of white spots, reduce the formation of new white spots, and reduce the occurrence of the Koebner phenomenon.

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Combination of NB‐UVB phototherapy and oral vitamin D supplementation in patients with generalized vitiligo: A randomized, triple‐blind, placebo‐controlled clinical trial

Cited by 2 publications

References 9 publications

Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases

Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases

Impact of Combined Phototherapy and Melanocyte Transplantation on Indicators of Vitiligo Activity

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