Combination of selol nanocapsules and magnetic hyperthermia hinders breast tumor growth in aged mice after a short-time treatment

Pinheiro, Willie Oliveira; Santos, Mayara Simonelly Costa dos; Farias, Gabriel Ribeiro; Fascineli, Maria Luiza; Rocha, Khellida Loiane Vieira Ramos; Duarte, Eliza Carla Barroso; Damasceno, Emanuel Adelino Medeiros; Silva, Jaqueline da; Joanitti, Graziella Anselmo; Azevedo, Ricardo Bentes; Mosiniewicz-Szablewska, E.; Suchocki, Piotr; Morais, P.C.; Lacava, Z.G.M.; Andrade, L.

doi:10.1088/1361-6528/ac504c

Cited by 2 publications

(1 citation statement)

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“…G5 group showed the strongest antitumor effect, with the slowest increase in tumor volume in all mice and an average tumor volume of about 600 mm 3 after 16 days. Then a comprehensive mathematical analysis using the following first-order differential equation was carried out where V means the tumor volume, t means the days of treatment, C represents the expected maximum tumor volume, and k represents the Malthusian-like fractional growth rate. In addition, the inflection time ( t i ) was introduced to represent the day tumor volume reached C /2, which was employed to describe the tumor volume changes from upward ( t < t i ) to downward ( t > t i ).…”

Section: Resultsmentioning

confidence: 99%

Inhalable Biomimetic Protein Corona-Mediated Nanoreactor for Self-Amplified Lung Adenocarcinoma Ferroptosis Therapy

Wang

Huang

et al. 2022

ACS Nano

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Ferroptosis therapy by catalyzing the Fenton reaction has emerged as a promising tumor elimination strategy for lung adenocarcinoma (ADC). However, the unsatisfactory Fenton reaction efficiency, strong intracellular antioxidant system, and insufficient lung drug accumulation limits the ferroptosis therapeutic effect. To address these issues, an inhalable nanoreactor was proposed by spontaneously adsorbing biomimetic protein corona (PC) composed of matrix metalloproteinase 2 responsive gelatin and glutamate (Glu) on the surface of cationic nanostructured lipid carriers (NLC) core loaded with ferrocene (Fc) and fluvastatin. The prepared Fc-NLC(F)@PC could be nebulized into lung lesions with 2.6 times higher drug accumulation and boost lipid peroxide production by 3.2 times to enhance ferroptosis therapy. Mechanically, fluvastatin was proved to inhibit monocarboxylic acid transporter 4 mediated lactate efflux, inducing tumor acidosis to boost Fc-catalyzing reactive oxygen species production, while the extracellular elevating Glu concentration was found to inhibit xCT (system Xc –) functions and further collapse the tumor antioxidant system by glutathione synthesis suppression. Mitochondrial dysfunction and cell membrane damage were involved in the nanoreactor-driven ferroptotic cell death process. The enhanced antitumor effects by combination of tumor acidosis and antioxidant system collapse were confirmed in an orthotopic lung ADC tumor model. Overall, the proposed nanoreactor highlights the pulmonary delivery approach for local lung ADC treatment and underscores the great potential of ferroptosis therapy.

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Section: Resultsmentioning

confidence: 99%