Combination of sodium butyrate and probiotics ameliorates severe burn-induced intestinal injury by inhibiting oxidative stress and inflammatory response

Zhou, Biao; Ba, Te; Wang, Lingfeng; Gao, Yixuan; He, Qiaoling; Yan, Zengqiang; Wang, Hongyu; Guo-liang, Shen

doi:10.1016/j.burns.2021.11.009

Cited by 9 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NaBu has attracted more attention because it is a natural and endogenous HDAC inhibitor with extensive pharmacological properties such as anti-oxidation, anti-inflammation, anti-tumor activities, etc. ,, Indeed, we found that NaBu had an excellent hepatoprotective role, consistent with the previous results that NaBu prevented hepatic damage upon DON exposure . NaBu has been reported to ameliorate intestinal injury by reducing OS and inflammation, and our data consistently confirmed that NaBu could inhibit the ROS and TNF-α pathways . Interestingly, NaBu has been found to exert an antioxidant effect by catalyzing HDAC activity to regulate the expression of NR PPARγ .…”

Section: Discussionsupporting

confidence: 90%

Sodium Butyrate Ameliorates Deoxynivalenol-Induced Oxidative Stress and Inflammation in the Porcine Liver via NR4A2-Mediated Histone Acetylation

Zong

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

Mycotoxin-induced liver injury is often accompanied by oxidative stress (OS) and inflammation. This research aimed to explore the potential mechanism of sodium butyrate (NaBu) in modulating hepatic anti-oxidation and anti-inflammation pathways in deoxynivalenol (DON)-exposed piglets. The results show that DON induced liver injury, increased mononuclear cell infiltration, and decreased serum total protein and albumin concentrations. Transcriptomic analysis revealed that reactive oxygen species (ROS) and TNF-α pathways were highly activated upon DON exposure. This is associated with disturbed antioxidant enzymes and increased inflammatory cytokines secretion. Importantly, NaBu effectively reversed the alterations caused by DON. Mechanistically, the ChIP-seq result revealed that NaBu strongly depressed DON-increased enrichment of histone mark H3K27ac at the genes involved in ROS and TNF-α-mediated pathways. Notably, we demonstrated that nuclear receptor NR4A2 was activated by DON and remarkably recovered with the treatment of NaBu. In addition, the enhanced NR4A2 transcriptional binding enrichments at the promoter regions of OS and inflammatory genes were hindered by NaBu in DON-exposed livers. Consistently, elevated H3K9ac and H3K27ac occupancies were also observed at the NR4A2 binding regions. Taken together, our results indicated that a natural antimycotic additive, NaBu, could mitigate hepatic OS and inflammatory responses, possibly via NR4A2-mediated histone acetylation.

show abstract

Section: Discussionsupporting

confidence: 90%

Sodium Butyrate Ameliorates Deoxynivalenol-Induced Oxidative Stress and Inflammation in the Porcine Liver via NR4A2-Mediated Histone Acetylation

Zong

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…After burn, because of necrotic tissue and bacterial translocation, various inflammatory cytokines, including IL‐1 and TNF‐a, are released in a disorderly manner, which triggers and aggravates the systemic inflammatory response 28 . A study reported 28 that the levels of IL‐1 and TNF‐a in the serum of burn patients were positively correlated with the degree of burn. Burn wound repair is a complex dynamic process of skin self‐repair through the interaction between various repair cells, growth factors and extracellular matrix after injury 29 .…”

Section: Discussionmentioning

confidence: 99%

Analysis of curative effect of insulin external application on burn wounds of diabetic patients with different depths

Yang

Xue

et al. 2022

International Wound Journal

View full text Add to dashboard Cite

To explore the curative effect of insulin external application on burn wounds of diabetic patients with different depths. A retrospective analysis of 114 diabetic burn patients in the First Hospital of Hebei Medical University from June 2019 to June 2022. According to the different treatment methods, they were divided into study group (insulin therapy) and control group (conventional therapy) with 57 cases in each. The wound healing time, dressing changes, scar healing after wound healing and adverse events were compared between two groups. Pain level, serum inflammatory factors, vascular endothelial growth factor (VEGF) and oxidative stress factors before and after treatment were compared. The wound healing time (17.23 ± 2.18 vs 20.31 ± 2.09 days) and the number of dressing changes (7.01 ± 1.23 vs 8.93 ± 1.32 times) in study group were significantly lower than those in control group (P < 0.05). Before treatment, there was no difference in pain level, VEGF, interleukin‐1 (IL‐1), tumour necrosis factor‐α (TNF‐α), malondialdehyde (MDA) and superoxide dismutase (SOD) between two groups (P > 0.05). However, the pain level, scar healing, IL‐1, TNF‐a and MDA in study group were significantly lower than those in control group after treatment (P < 0.05). And the VEGF and SOD in study group was significantly higher than that in control group (P < 0.05). External application of insulin can shorten the wound healing time of diabetic patients with different depths, reduce the number of dressing changes, promote scar healing after wound healing, relieve pain and reduce the level of inflammatory factors, which is worthy of clinical promotion.

show abstract

“…Treatment is adapted for each patient, targeting the symptoms or the involved organ with a range of drugs including immunomodulatory drugs [11], so many researches are carried out in an attempt to introduce new agents effective for scleroderma. NaB is one of the histone deacetylase inhibitors (HDAC) having potent antioxidant, immunomodulatory and anti-inflammatory properties through inhibition of the production of pro-inflammatory enzymes and cytokines [12]. Butyrate can influence the immune response by affecting immune cell migration, adhesion, and cellular functions such as proliferation and apoptosis [13].…”

Section: Introductionmentioning

confidence: 99%

Sodium Butyrate as Adjuvant Therapy with Mycophenolate Mofetil for Amelioration of Skin Fibrosis in Bleomycin-induced Scleroderma in Mice via Immunomodulatory, Antioxidant, Antiapoptotic and Antifibrotic Mechanisms

Othman

Abdelmaaboud

Abdin

et al. 2022

JAMMR

View full text Add to dashboard Cite

Background: Scleroderma is an autoimmune, multi-organ disease; its clinical hallmark is cutaneous and systemic fibrosis. Up to date, there is no definite cure. Aim of the Study: The aim of this study was to investigate the potential effects of sodium butyrate (NaB), and mycophenolate mofetil (MMF) each alone or both in a mice model of scleroderma induced by bleomycin (BLM), and to clarify some of their possible mechanisms on oxidative stress, immunological pattern, apoptosis, inflammation and fibrosis. Methods: This study was carried out on 50 Balb/C mice, divided into 5 equal groups. Serum levels of anticentromere antibody (ACA), and skin tissue levels of the following parameters were assayed: transforming growth factor-β1 (TGF-β1), interleukin-4 (IL-4), malondialdehyde (MDA), and superoxide dismutase (SOD). Tissue sections were examined for histopathological changes, dermal thickness, and immunohistochemical expression of caspase- 3, and α-smooth muscle actin (α-SMA). Results and Conclusion: The combined group showed a significant decline in TGF-β1, IL-4, MDA levels, caspase-3, and α-SMA, as well as a significant increase in SOD. Moreover, marked reduction in dermal fibrosis and dermal thickness compared to monotherapy by either NaB or MMF. The combination of NaB and MMF is a promising candidate for the treatment of scleroderma.

show abstract

Combination of sodium butyrate and probiotics ameliorates severe burn-induced intestinal injury by inhibiting oxidative stress and inflammatory response

Cited by 9 publications

References 27 publications

Sodium Butyrate Ameliorates Deoxynivalenol-Induced Oxidative Stress and Inflammation in the Porcine Liver via NR4A2-Mediated Histone Acetylation

Sodium Butyrate Ameliorates Deoxynivalenol-Induced Oxidative Stress and Inflammation in the Porcine Liver via NR4A2-Mediated Histone Acetylation

Analysis of curative effect of insulin external application on burn wounds of diabetic patients with different depths

Sodium Butyrate as Adjuvant Therapy with Mycophenolate Mofetil for Amelioration of Skin Fibrosis in Bleomycin-induced Scleroderma in Mice via Immunomodulatory, Antioxidant, Antiapoptotic and Antifibrotic Mechanisms

Contact Info

Product

Resources

About