Combination of supercritical fluid extraction and gas chromatography-mass spectrometry: Determination of impurities extracted from tablet preparations of the benzodiazepine series

Bochkareva, N. L.; Glazkov, I. N.; Revelsky, I. A.

doi:10.1134/s1061934806110074

Cited by 9 publications

(4 citation statements)

References 7 publications

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“…The first hyphenated method was GC-MS, and it is still essential for confirming the presence of residual solvents and organic volatile IMPs in samples (45)(46)(47)(48) . However, for the majority of organic impurities and degradants, the characteristics of analytes necessary for GC-MS, such as volatility and thermal stability, are unknown beforehand.…”

Section: Gc-msmentioning

confidence: 99%

A Review of Stability Indicating Methods and Forced Degradation Studies

Sonawane,

Chavan,

Narkar

et al. 2023

Int. J. Res. Publ. Rev.

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Stability testing of pharmaceutical products is a complex collection of processes requiring significant expense, time consumption, and scientific skill. In order to improve the quality, efficacy, and safety of a pharmaceutical product, stability testing of drug substances and products is an important step in determining the best storage options and recommending labeling guidelines. The forced degradation parameter performed under stability testing is Hydrolytic degradation, Oxidation degradation, Acidic degradation, Alkaline degradation, and Thermal degradation. In this paper, we present a comprehensive review of the current state of the art of Conventional Techniques and Hyphenated Techniques in the analysis of drug degradation products. We also provide an overview of recent advances in high-performance liquid chromatography (HPLC) and Method development of pharmaceutical drugs.

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Section: Gc-msmentioning

confidence: 99%

A Review of Stability Indicating Methods and Forced Degradation Studies

Sonawane,

Chavan,

Narkar

et al. 2023

Int. J. Res. Publ. Rev.

View full text Add to dashboard Cite

show abstract

“…GC-MS was the first technique to be hyphenated and continues to be indispensible for the confirmation of organic volatile IMPs [83][84][85][86] and residual solvents [87][88][89] present in a sample. However, the properties of analytes essential for GC-MS, like volatility and thermal stability, are not known pre-hand for most organic IMPs and DPs.…”

Section: Gc-msmentioning

confidence: 99%

A critical review on the use of modern sophisticated hyphenated tools in the characterization of impurities and degradation products

Singh

Handa

Narayanam

et al. 2012

Journal of Pharmaceutical and Biomedical Analysis

188

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“…91 Very low detection limits for the latter compounds have been achieved by using GC/MS-MS. 92 This scientific team has proposed a method for the determination of moderately volatile organic impurities in pharmaceutical tablet preparations and hairs based on a combination of solvent-free supercritical fluid extraction and GC/MS. 93,94 Another developed approach involved a combination of capillary chromadistillation with EI mass spectrometry. 95 It allowed highly sensitive determination of compounds with different volatility.…”

Section: Doping-controlmentioning

confidence: 99%

Mass Spectrometry in Russia

Заикин

Сысоев

2013

Eur J Mass Spectrom (Chichester)

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The present review covers the main research in the area of mass spectrometry from the 1990s which was about the same time as the Russian Federation emerged from the collapse of the Soviet Union (USSR). It consists of two main parts-application of mass spectrometry to chemistry and related fields and creation and development of mass spectrometric technique. Both traditional and comparatively new mass spectrometric methods were used to solve various problems in organic chemistry (reactivity of gas-phase ions, structure elucidation and problems of identification, quantitative and trace analysis, differentiation of stereoisomers, derivatization approaches etc.), biochemistry (proteomics and peptidomics, lipidomics), medical chemistry (mainly the search of biomarkers, pharmacology, doping control), environmental, petrochemistry, polymer chemistry, inorganic and physical chemistry, determination of natural isotope ratio etc. Although a lot of talented mass spectrometrists left Russia and moved abroad after the collapse of the Soviet Union, the vitality of the mass spectral community proved to be rather high, which allowed the continuation of new developments in the field of mass spectrometric instrumentation. They are devoted to improvements in traditional magnetic sector mass spectrometers and the development of new ion source types, to analysis and modification of quadrupole, time-of-flight (ToF) and ion cyclotron resonance (ICR) analyzers. The most important achievements are due to the creation of multi-reflecting ToF mass analyzers. Special attention was paid to the construction of compact mass spectrometers, particularly for space exploration, of combined instruments, such as ion mobility spectrometer/mass spectrometer and accelerating mass spectrometers. The comparatively young Russian Mass Spectrometry Society is working hard to consolidate the mass spectrometrists from Russia and foreign countries, to train young professionals on new appliances and regularly holds conferences on mass spectrometry. For ten years, a special journal Mass-spektrometria has published papers on all disciplines of mass spectrometry.

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Combination of supercritical fluid extraction and gas chromatography-mass spectrometry: Determination of impurities extracted from tablet preparations of the benzodiazepine series

Cited by 9 publications

References 7 publications

A Review of Stability Indicating Methods and Forced Degradation Studies

A Review of Stability Indicating Methods and Forced Degradation Studies

A critical review on the use of modern sophisticated hyphenated tools in the characterization of impurities and degradation products

Mass Spectrometry in Russia

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