Combination of the Microfluidic System and NiO Uric Acid Biosensor Modified by Ag Nanomaterials

Chou, Jung-Chuan; Lai, Tsu-Yang; Kuo, Po-Yu; Lai, Chih-Hsien; Nien, Yu–Hsun; Huang, Yuhao; Chen, Yung-Yu; Lee, Kun-Tse

doi:10.1109/access.2021.3132359

Cited by 2 publications

(2 citation statements)

References 29 publications

(26 reference statements)

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“…Then, the measuring sensor responds to changes in voltage under different pH cycles. Eventually, the final response voltage of the sensor and the initial response voltage will shift, which is called hysteresis voltage [48] between measuring the next concentration. Wait 2 minutes until the voltage is stable, while each pH concentration responded for about 60 seconds.…”

Section: H Hysteresis Effects Of the Sensormentioning

confidence: 99%

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ZnO Film Flexible Printed Circuit Board pH Sensor Measurement and Characterization

2022

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An electrochemical zinc oxide (ZnO) pH sensor is proposed and prototyped using a flexible printed circuit board (FPCB). The device is resistant to acidic and alkaline solutions and exhibits excellent electrical conductivity. The sensing film was deposited by radio-frequency sputtering, providing a dense ZnO layer, and (3-aminopropyl)triethoxysilane (APTES) was used to enhance the chemical stability of the ZnO in acidic solutions. The proposed pH sensor has an average sensitivity of 37.52 mV/pH, linearity of 0.995, and a repeatable RSD value of 2.4%. Testing was conducted with Carmody's buffer pH 2-10 and a voltage-time measurement system. The stability of the prototype was determined by the measurement of the drift and hysteresis effects.INDEX TERMS pH sensor, biosensor, zinc oxide (ZnO), flexible printed circuit board (FPCB). 111 328 nanorod without APTES modified ZnO film. Since APTES 329 was modified, our measurement concentration range 330 includes pH 2-10. Also, compared to recent ZnO with 331 APTES research [21], the sensitivity without APTES was 332 36.6 mV/pH and with APTES was 43.2 mV/pH. Because of 333 the nanostructure, the voltage sensitivity was slightly better 334 than our work. Meanwhile, compared with other materials 335 studied, such as the Ta pH sensor [52], although it has 336 slightly better performance, ZnO is more advantageous in 337 terms of cost. Compared with the SPR/LSPR fiber-optic pH 338 sensor [53], the traditional thin-film sensing method also has 339 essential advantages of low cost and intuitive measurement.340 IV. CONCLUSION 341 In this study, a dense ZnO layer was successfully sputtered 342 on an FPCB with an ENIG layer to produce a pH sensor with 343 good sensitivity. Applying an APTES coating on the ZnO 344 film improved film resistance in an acidic solution. Appro-345 priate APTES layers can be used to coat the ZnO thin films 346 and prevent degradation in pH 2 solution. Characteristics of 347 the device were measured, including time drift, hysteresis 348 effects, and repeatability. These showed that FPCB could be 349 an excellent electrochemical sensor substrate. This study's 350 APTES/ZnO FPCB pH sensor has an average sensitivity of 351 37.52 mV/pH and linearity of 0.995. 352 REFERENCES 353 [1] A. Safavi and M. Bagheri, ''Novel optical pH sensor for high and low354

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Section: H Hysteresis Effects Of the Sensormentioning

confidence: 99%

“…The drift rate is calculated by subtracting the fifth-hour value from the twelfth hour value and dividing it by the 7 hours difference. In this case, the overall drift rate was 8.5 mV/hour, and the formula is shown below in (7) [48].…”

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confidence: 99%