Combination of thymol and eugenol for the control of Rhipicephalus sanguineus sensu lato: Evaluation of synergism on immature stages and formulation development

Coelho, Letícia; Paula, Luiza Gabriella Ferreira de; Alves, Susy das Graças Alecrim; Sampaio, Aparecida Lorrany Nunes; Bezerra, Giovana Pereira; Vilela, Fernanda Maria Pinto; Matos, Renata da Silva; Zeringóta, Viviane; Borges, Lígia Miranda Ferreira; Monteiro, Caio Márcio de Oliveira

doi:10.1016/j.vetpar.2019.108989

Cited by 30 publications

(10 citation statements)

References 43 publications

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“…The mortality activity of EOs containing EG against R. sanguineus larvae has already been described (Coelho et al, 2020;Ferreira et al, 2019). Ferreira et al (2019) evaluated the EO of O. gratissimum (74.5% EG) and despite the largest proportion of EG, the LC 50 that they found was higher (LC 50 = 6.2 mg.mL -1 ) than what we found for EOSA (61% EG) (LC 50 = 3.29 mg.mL -1 ).…”

Section: Discussionmentioning

confidence: 51%

“…The larvicidal activity of EG alone against R. microplus (Araújo et al, 2016;Ferreira et al, 2018;Monteiro et al, 2012;Novato et al, 2018;Valente et al, 2014) and R. sanguineus (Araújo et al, 2016;Coelho et al, 2020;Senra et al, 2013) have already been described. The concentrations with which 100% mortality against R. microplus was achieved ranged from 3 mg.mL -1 (Valente et al, 2014) to 5 mg.mL -1 (Ferreira et al, 2018;Monteiro et al, 2012) and 15 mg.mL -1 (Novato et al, 2018).…”

Section: Discussionmentioning

confidence: 94%

“…The LC 50 values ranged from 1.7 mg.mL -1 (Valente et al, 2014) to 2.77 mg.mL -1 (Novato et al, 2018) and 4.76 mg.mL -1 (Araújo et al, 2016). Mortality above 99% was reached at higher concentrations for R. sanguineus than for R. microplus (Araújo et al, 2016;Coelho et al, 2020;Senra et al, 2013). We found mortality above 99% at a higher concentration (40 mg.mL -1 ) than what was reported by Senra et al (2013) (10 mg.mL -1 ) and Coelho et al (2020) (20 mg.mL -1 ).…”

Section: Discussionmentioning

confidence: 96%

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In vitro evaluation of the acaricidal activity of Syzygium aromaticum (L.) essential oil and eugenol against non-fed larvae of Rhipicephalus sanguineus

et al. 2021

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 96%

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In vitro evaluation of the acaricidal activity of Syzygium aromaticum (L.) essential oil and eugenol against non-fed larvae of Rhipicephalus sanguineus

et al. 2021

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“…Both clove essential oil and eugenol resulted in significantly reduced egg production index (EPI) and hatching. The acaricidal effect of eugenol on R. sanguineus unfed larvae, unfed nymphs, fed larvae, and fed nymphs was demonstrated by a later study [ 171 ]. More significant mortalities were achieved when eugenol and thymol were combined.…”

Section: Plant-derived Compounds With Potential Use For Tick Pest mentioning

confidence: 99%

“…More significant mortalities were achieved when eugenol and thymol were combined. Furthermore, this formulation reduced application costs to $3.96/L [ 171 ].…”

Section: Plant-derived Compounds With Potential Use For Tick Pest mentioning

confidence: 99%

Plant-Derived Natural Compounds for Tick Pest Control in Livestock and Wildlife: Pragmatism or Utopia?

Quadros¹,

Johnson

Whitney³

et al. 2020

Insects

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Ticks and tick-borne diseases are a significant economic hindrance for livestock production and a menace to public health. The expansion of tick populations into new areas, the occurrence of acaricide resistance to synthetic chemical treatments, the potentially toxic contamination of food supplies, and the difficulty of applying chemical control in wild-animal populations have created greater interest in developing new tick control alternatives. Plant compounds represent a promising avenue for the discovery of such alternatives. Several plant extracts and secondary metabolites have repellent and acaricidal effects. However, very little is known about their mode of action, and their commercialization is faced with multiple hurdles, from the determination of an adequate formulation to field validation and public availability. Further, the applicability of these compounds to control ticks in wild-animal populations is restrained by inadequate delivery systems that cannot guarantee accurate dosage delivery at the right time to the target animal populations. More work, financial support, and collaboration with regulatory authorities, research groups, and private companies are needed to overcome these obstacles. Here, we review the advancements on known plant-derived natural compounds with acaricidal potential and discuss the road ahead toward the implementation of organic control in managing ticks and tick-borne diseases.

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Monoterpenoid synergy: a new frontier in biological applications

Begh,

Khan,

Al Amin

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Combination of thymol and eugenol for the control of Rhipicephalus sanguineus sensu lato: Evaluation of synergism on immature stages and formulation development

Cited by 30 publications

References 43 publications

In vitro evaluation of the acaricidal activity of Syzygium aromaticum (L.) essential oil and eugenol against non-fed larvae of Rhipicephalus sanguineus

In vitro evaluation of the acaricidal activity of Syzygium aromaticum (L.) essential oil and eugenol against non-fed larvae of Rhipicephalus sanguineus

Plant-Derived Natural Compounds for Tick Pest Control in Livestock and Wildlife: Pragmatism or Utopia?

Monoterpenoid synergy: a new frontier in biological applications

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