Combination of Two Urinary Biomarkers Predicts Acute Kidney Injury After Adult Cardiac Surgery

Katagiri, Daisuke; Doi, Kent; Honda, Kenjiro; Negishi, Kousuke; Fujita, Toshiro; Hisagi, Motoyuki; Ōno, Minoru; Matsubara, Takehiro; Yahagi, Naoki; Iwagami, Masao; Ohtake, Takayasu; Kobayashi, Shuzo; Sugaya, Takeshi; Noiri, Eisei

doi:10.1016/j.athoracsur.2011.10.048

Cited by 112 publications

(94 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…128,131 Similar results have been observed in patients admitted to the ICU with sepsis. 132 Yamamoto et al 126 have studied the potential role of L-FABP as a biomarker of renal ischemia following human kidney transplantation from living-related donors.…”

supporting

confidence: 81%

The potential use of biomarkers in predicting contrast-induced acute kidney injury

Andreucci¹,

Faga²,

Riccio³

et al. 2016

IJNRD

View full text Add to dashboard Cite

Contrast-induced acute kidney injury (CI-AKI) is a problem associated with the use of iodinated contrast media, causing kidney dysfunction in patients with preexisting renal failure. It accounts for 12% of all hospital-acquired kidney failure and increases the length of hospitalization, a situation that is worsening with increasing numbers of patients with comorbidities, including those requiring cardiovascular interventional procedures. So far, its diagnosis has relied upon the rise in creatinine levels, which is a late marker of kidney damage and is believed to be inadequate. Therefore, there is an urgent need for biomarkers that can detect CI-AKI sooner and more reliably. In recent years, many new biomarkers have been characterized for AKI, and these are discussed particularly with their use in known CI-AKI models and studies and include neutrophil gelatinase-associated lipocalin, cystatin C (Cys-C), kidney injury molecule-1, interleukin-18, N-acetyl-β-d-glucosaminidase, and L-type fatty acid-binding protein (L-FABP). The potential of miRNA and metabolomic technology is also mentioned. Early detection of CI-AKI may lead to early intervention and therefore improve patient outcome, and in future any one or a combination of several of these markers together with development in technology for their analysis may prove effective in this respect.

show abstract

supporting

confidence: 81%

The potential use of biomarkers in predicting contrast-induced acute kidney injury

Andreucci¹,

Faga²,

Riccio³

et al. 2016

IJNRD

View full text Add to dashboard Cite

show abstract

“…30 In a study performed in patients following cardiac surgery, NAG and urinary L-FABP were shown to be highly specific and highly sensitive, respectively, in demonstrating AKI. 31 In the present study, the reason for high levels of urinary NGAL/Cr, NAG/Cr, and L-FABP/ Cr might be subclinical kidney injury secondary to hypoxia that occurred in the patients during and after convulsions. This study had some limitations, including a limited number of patients with FS and only once measurement of urinary markers.…”

Section: Discussionmentioning

confidence: 57%

Urinary kidney injury molecules in children with febrile seizures

et al. 2016

View full text Add to dashboard Cite

Objective: Hypoxia occurs following convulsions, and hypoxia is one of the most common causes of acute renal damage. The aim of this study was to investigate urinary levels of kidney injury molecules, including neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-b-D-glucosaminidase (NAG), and liver-type fatty acid-binding protein (L-FABP) in children with febrile seizures (FS) for the first time. Methods: The study included 28 children with FS and 34 age and gender matched healthy children. Serum biochemistry and blood gases were measured in the serum samples. Estimated glomerular filtration rate (eGFR) was calculated. NGAL, NAG, L-FABP, and creatinine (Cr) were measured in the urine samples. The ratios of kidney injury markers to urinary Cr were used for comparisons.Results: There were no significant differences in eGFR and serum chemistry values between the FS and the control group (p > 0.05). Hypoxia was detected in 67.9% of the FS patients. The FS group had significantly higher urinary kidney injury molecules to Cr ratios compared to the controls, including NGAL/Cr (17.9 ± 9.8; 6.7 ± 4.0, respectively; p < 0.001), NAG/Cr (0.55 ± 0.29; 0.21 ± 0.16, p < 0.001), and L-FABP/Cr (4.85 ± 2.93; 1.74 ± 1.16, p < 0.001). Conclusion: Increased urinary NGAL/Cr, NAG/Cr, and L-FABP/Cr values, in patients with FS compared to healthy controls, suggest a possible subclinical renal damage in these patients. ARTICLE HISTORY

show abstract

“…The utility of biomarker combinations in AKI prediction has been assessed by a number of studies in cardiac surgery patients, which reported improved predictive performance for the various combinations they used. [71][72][73][74][75] Nevertheless, which are the optimal combinations of biomarkers, remain unclear. We have recently reported that the combinations of novel biomarkers with a conventional one (pNGAL þ uNGAL þ sCr) are promising in the heterogeneous population of a general adult ICU.…”

Section: Limitations and Methodological Issues Of The Novel Biomarkermentioning

confidence: 99%

“…30 Some authors suggest that the ideal combination should include a biomarker with a high sensitivity and another one with a high specificity. 74 We selected our combinations after statistically comparing the AUCs of all possible combinations. 30 Larger studies that will identify the most efficient and cost-effective biomarker combinations and will develop and validate AKI scoring systems are required.…”

Section: Limitations and Methodological Issues Of The Novel Biomarkermentioning

confidence: 99%

Novel Biomarkers of Acute Kidney Injury in the General Adult ICU: A Review

et al. 2013

View full text Add to dashboard Cite

Acute kidney injury is one of the most frequent problems occurring in the critically ill patients of the intensive care units and it is well established that it increases both morbidity and mortality in these patients. Moreover, despite technological and pharmaceutical advances during the last decades, the incidence as well as the mortality associated with acute kidney injury in these patients remains unchanged. Creatinine, the most common renal dysfunction biomarker in use, has many disadvantages, such as time delay in its increase and the influence by other factors on its serum concentration, such as age, gender, muscle mass, etc. Hence, the need for better renal biomarkers in order to timely intervene for acute kidney injury prevention is imperative. The lack of an early biomarker is an obstacle for the development of new acute kidney injury prevention strategies. With the incidence of acute kidney injury reaching epidemic dimensions, the need for novel markers is urgent. During the last years, the research for finding such biomarkers has been intense. The purpose of the present article is to review the studies which have tested the predictive ability of those markers (in urine and/or plasma) for early detection of acute kidney injury in the mixed adult intensive care unit population and underline the potential limitations encountered in the various studies.

show abstract

Combination of Two Urinary Biomarkers Predicts Acute Kidney Injury After Adult Cardiac Surgery

Cited by 112 publications

References 31 publications

The potential use of biomarkers in predicting contrast-induced acute kidney injury

The potential use of biomarkers in predicting contrast-induced acute kidney injury

Urinary kidney injury molecules in children with febrile seizures

Novel Biomarkers of Acute Kidney Injury in the General Adult ICU: A Review

Contact Info

Product

Resources

About