Combination of Uric Acid and NT-ProBNP: A More Useful Prognostic Marker for Short-Term Clinical Outcomes in Patients with Acute Heart Failure

Park, Hyoung Seob; Kim, Hyung Seop; Sohn, Ji Hyun; Shin, Hong Won; Cho, Yun–Kyeong; Yoon, Hyuck Jun; Nam, Chang Wook; Hur, Seung‐Ho; Kim, Yoon Nyun; Kim, Kwon Bae; Park, Hee Joon

doi:10.3904/kjim.2010.25.3.253

Cited by 24 publications

(23 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…10,23 While BUN/ Crea was suggested as an indicator of renal perfusion, 25-27 acute ischemic kidney challenge in AHF was also identified as a determinant of uric acid level. 24 Therefore, we may conclude that hyperuricemia is a complicated phenomenon involving cardiac performance, kidney function, and cardiorenal interaction.…”

Section: Hyperuricemia and Ckdmentioning

confidence: 99%

“…Hyperuricemia and Acute HF kidney damage might be the dominant factor for hyperuricemia in AHF. 24 In the present study, the major determinants of uric acid level were eGFR, BUN/Crea, and LVEF on multiple linear regression stepwise analysis. In addition to renal function, we also showed that ventricular performance independently correlated with uric acid level, consistent with the previous findings in either CHF or AFH.…”

Section: Hyperuricemia and Ckdmentioning

confidence: 99%

See 1 more Smart Citation

Determinants and Prognostic Impact of Hyperuricemia in Hospitalization for Acute Heart Failure

Huang

Hsu

Cheng

et al. 2016

Circ J

View full text Add to dashboard Cite

Section: Hyperuricemia and Ckdmentioning

confidence: 99%

Section: Hyperuricemia and Ckdmentioning

confidence: 99%

Determinants and Prognostic Impact of Hyperuricemia in Hospitalization for Acute Heart Failure

Huang

Hsu

Cheng

et al. 2016

Circ J

View full text Add to dashboard Cite

“…Although numerous parameters indicate the prognosis of heart failure, most are costly to evaluate and are assessed only in research. 4) Red cell distribution width (RDW) is a measure of the variability in size of circulating erythrocytes. 5) This parameter is a widely investigated and routine laboratory value reported as a component of complete blood count.…”

mentioning

confidence: 99%

Comparison of Prognostic Value of Red Cell Distribution Width and NT-proBNP for Short-Term Clinical Outcomes in Acute Heart Failure Patients

Jia

Chen

et al. 2014

Int. Heart J.

View full text Add to dashboard Cite

SummaryComparison of the prognostic value of red cell distribution width (RDW) and N-terminal pro B-type natriuretic peptide (NT-proBNP) for short-term clinical outcomes in acute heart failure (AHF) patients has not been fully investigated.A total of 128 patients with AHF were enrolled and followed for 3 months. Primary endpoints were cardiovascular (CV) events, defi ned as cardiac death and/or readmission for HF. Baseline RDW and NT-proBNP were measured at admission.The 30-day and 90-day CV event rates were 16.4% and 35.9%, respectively. NT-proBNP was higher in people with cardiovascular events at both time points, while RDW was signifi cantly higher only at the 90-day time point. The area under the ROC curve of RDW (area under the ROC curve = 0.695) for the prediction of CV events was higher than that of NT-proBNP (area under the ROC curve = 0.610) at the 90-day time point, but lower at the 30-day time point. Cox hazard analysis revealed RDW and NT-proBNP were independent predictive factors of a 90-day CV event (RDW, hazard ratio, 4.610, 95% confi dence interval 1.935-10.981, P = 0.001; NT-proBNP, hazard ratio, 3.661, 95% confi dence interval 1.125-11.907, P = 0.031). Kaplan-Meier survival analysis revealed that patients with an RDW level > 14.5% and NT-proBNP > 1471.5 pg/mL were at highest risk for a CV event (P < 0.001).RDW and NT-proBNP are strong independent predictors of 90-day cardiovascular events in patients hospitalized with AHF. RDW can add prognostic value to NT-proBNP for predicting early cardiovascular events. (Int Heart J 2014; 55: 58-64) Key words: Marker, Prognosis A cute heart failure (AHF) has been defi ned as new-onset or gradual or rapidly worsening heart failure signs and symptoms requiring urgent therapy. 1) It is the leading cause of hospitalization in adults over 65 years.2) AHF may result from new onset of ventricular dysfunction or, more typically, exacerbation of chronic heart failure symptoms. 3)Recognizing such higher risk patients, however, may be challenging. Although numerous parameters indicate the prognosis of heart failure, most are costly to evaluate and are assessed only in research.4) Red cell distribution width (RDW) is a measure of the variability in size of circulating erythrocytes. 5)This parameter is a widely investigated and routine laboratory value reported as a component of complete blood count.A previous study has shown RDW can be a significant independent predictor of all-cause mortality and hospital readmission for patients with chronic heart failure (CHF).6) It was also found to be an independent and addictive predictor of early mortality in patients with acute dyspnea. 7) Higher levels of RDW correlate to poorer survival in stroke, 8) myocardial infarction 9) and pulmonary hypertension. 10) However, little is known about the prognostic value of RDW in the short-term outcome in acute heart failure. Accordingly, in order to determine the prognostic utility of RDW in short-term adverse outcome in patients with AHF, we conducted a prospective study to compare RDW ...

show abstract

“…In fact, renal estimation by BUN, Cr, or GFR is usually reliable on stable conditions, but it is less useful when sudden renal function changes develop. However, UA and Cys could provide a more stable evaluation of renal function in patients with acute HF 10,24–26 . Cys is a marker of renal function evaluation, but it has been a more sensitive tool for reflecting renal dysfunction, particularly even at the atmosphere of normal or mild elevation of Cr 27 .…”

Section: Discussionmentioning

confidence: 99%

“…UA has been considered a metabolic marker, while Cys has been considered an early marker for acute kidney injury 5–8 . Based on these characteristics, UA and Cys may be used for the prognosis of HF or ischemic heart disease (IHD) 9–12 …”

mentioning

confidence: 99%

Potentials of Cystatin C and Uric Acid for Predicting Prognosis of Heart Failure

Kim

Yoon

Park

et al. 2012

Congestive Heart Failure

Self Cite

View full text Add to dashboard Cite

Few studies have explored the clinical potentials of combined Cystatin C (Cys) and uric acid (UA) in heart failure (HF). The authors evaluated Cys and UA as predictors of clinical outcomes compared with conventional renal biomarkers. This prospective cohort study included 587 HF patients presenting with dyspnea. At admission, Cys, UA, and other renal measures including serum urea nitrogen (BUN), creatinine (Cr), and glomerular filtration rate (GFR) were obtained. The primary endpoint was the composite of cardiac death and rehospitalization for worsening HF. During a 25‐month median follow‐up period, 68 patients experienced clinical outcomes: 9 cardiac deaths and 59 HFs. They showed higher BUN and Cr values and lower GFR. Within these parameters, Cys and UA had the most favorable area under the curves, and patients with Cys ≥0.8 mg/L and UA ≥6.6 mg/dL showed more frequent events. The net reclassification improvement analysis showed the combination of Cys and UA had a greater incremental effect for cardiac prognosis. On multivariate Cox hazard analysis, Cys and UA were independent predictive markers for clinical outcomes. In HF patients presenting with dyspnea, Cys and UA appear to be more useful predictors of clinical events than other renal measures.

show abstract

Combination of Uric Acid and NT-ProBNP: A More Useful Prognostic Marker for Short-Term Clinical Outcomes in Patients with Acute Heart Failure

Cited by 24 publications

References 26 publications

Determinants and Prognostic Impact of Hyperuricemia in Hospitalization for Acute Heart Failure

Determinants and Prognostic Impact of Hyperuricemia in Hospitalization for Acute Heart Failure

Comparison of Prognostic Value of Red Cell Distribution Width and NT-proBNP for Short-Term Clinical Outcomes in Acute Heart Failure Patients

Potentials of Cystatin C and Uric Acid for Predicting Prognosis of Heart Failure

Contact Info

Product

Resources

About