Combination of vitamin C and E modulated monosodium glutamate-induced endometrial toxicily in female Wistar rats

Wahyuni, Elly; Situmorang, Cory Chorajon; Yueniwati, Yuyun; Barlıanto, Wisnu; Dwijayasa, Pande Made

doi:10.1016/s2305-0500(14)60012-9

Cited by 9 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the research results, data is obtained that the average thickness of vaginal epithelium in the negative control groups that were not given MSG is higher than that in the positive control groups that were given MSG orally. These results are consistent with studies that had been conducted by Wahyuni et al (2014) that the administration of MSG in female mice can inhibit the ER-α in the endometrium of the uterus. This is also reinforced by evidence that there is a thinning in the endometrium of mice given MSG orally.…”

Section: Resultssupporting

confidence: 92%

THE EFFECT OF ADMINISTERING RHIZOME EXTRACT OF CURCUMA (Curcuma Xanthorrhiza Roxb.) AT VARIOUS DOSES ON THE THICKNESS OF VAGINAL EPITHELIUM IN MICE (Mus Musculus) EXPOSED TO MSG

Atmaja¹

2017

J. Islamic Pharm.

View full text Add to dashboard Cite

show abstract

Section: Resultssupporting

confidence: 92%

THE EFFECT OF ADMINISTERING RHIZOME EXTRACT OF CURCUMA (Curcuma Xanthorrhiza Roxb.) AT VARIOUS DOSES ON THE THICKNESS OF VAGINAL EPITHELIUM IN MICE (Mus Musculus) EXPOSED TO MSG

Atmaja¹

2017

J. Islamic Pharm.

View full text Add to dashboard Cite

show abstract

“…However, several studies have shown the adverse effects of MSG on the female reproductive system [10] , [11] . Few studies have used MSG to create an animal model of obesity and uterine hyperplasia [12] , [13] .…”

Section: Introductionmentioning

confidence: 99%

Protective effects of alpha stone on monosodium glutamate-induced uterine hyperplasia in female wistar rats

Oyebode

Obiekwe

Olorunsogo

2020

Journal of Ayurveda and Integrative Medicine

View full text Add to dashboard Cite

Background Uterine leiomyomas (fibroids), a menace of the reproductive age, is characterized by proliferation of smooth muscle cells (hyperplasia) of the uterus. Alpha Stone Decoction is a poly-herbal formulation that is used for the shrinkage and prevention of uterine fibroids in folkore medicine. Objective We investigated the efficacy and safety of Alpha Stone Decoction (ASD), on monosodium glutamate (MSG) induced uterine hyperplasia. Materials and methods Twenty-eight mature virgin female rats were randomly divided into four study groups: A-control B- MSG (200 mg/kgbw), C- MSG + ASD (100 mg/kgbw) and D- ASD 100 mg/kgbw alone. The administration was carried out by as a single daily dose via intraperitoneal route for 14 days. Total protein, triglycerides, estradiol (estrogen), progesterone, and total cholesterol levels in sera were determined using appropriate kits. Uterine hyperplasia was assessed via histomorphometric method using the mitotic image plus software to compute the fibroblast cell count density while the uteri and ovaries of animals were stained with mason-tricon stain for histological examination. Results Administration of MSG for 14 days resulted heavy deposits of collagen connective tissue within the myometrium layers of the uteri. ASD significantly (p < 0.05) reduced fibroblast cell count in MSG-treated animals and also protected against MSG-induced damage observed in the myometrium of the uteri and ovaries of the animals. Significant increases (p < 0.05) in levels of total protein; triglycerides, progesterone, cholesterol and estrogen in the MSG-treated animals were ameliorated following administration of ASD. Conclusion These findings suggest that ASD contains bioactive agents which reversed MSG-induced uterine hyperplasia. It may therefore be useful in reducing the proliferation of fibroblast cells and managing other symptoms associated with uterine myoma.

show abstract

“…The histopathological profile of the uterine cervical tissues was analyzed using HE staining based on the previous study [8] . An experienced pathologist was appointed to count the number of cervical epithelial cells in proliferation state.…”

Section: Methodsmentioning

confidence: 99%

Rhodamine B induces oxidative stress and cervical epithelial cell proliferation in the uterus

2015

View full text Add to dashboard Cite

This study aimed to investigate the effect of Rhodamine B exposure on oxidative stress and cervical epithelial cells proliferation in the uterus. Twenty eight female Wistar albino rats were divided into four groups (n = 7 each): one control (untreated) group; and three Rhodamine B groups at several doses (4.5, 9, 18 mg/200 g body weight/day) for 36 days. Colometric analysis of malondialdehyde (MDA) level as a marker of lipid peroxidation and histological analysis of the cervical epithelial cells proliferation was performed. The MDA levels and proliferation of epithelial cells were significantly higher in all Rhodamine B groups compared to control group (P < 0.05). The MDA levels were increased in a dose-dependent manner in the Rhodamine B groups. Moreover, the proliferation of epithelial cells was also increased by Rhodamine B in a dose-dependent manner. In conclusion, subchronic Rhodamine B administration induces lipid peroxidation and cervical epithelial cells proliferation in a dose dependent manner.

show abstract

Combination of vitamin C and E modulated monosodium glutamate-induced endometrial toxicily in female Wistar rats

Cited by 9 publications

References 13 publications

THE EFFECT OF ADMINISTERING RHIZOME EXTRACT OF CURCUMA (Curcuma Xanthorrhiza Roxb.) AT VARIOUS DOSES ON THE THICKNESS OF VAGINAL EPITHELIUM IN MICE (Mus Musculus) EXPOSED TO MSG

THE EFFECT OF ADMINISTERING RHIZOME EXTRACT OF CURCUMA (Curcuma Xanthorrhiza Roxb.) AT VARIOUS DOSES ON THE THICKNESS OF VAGINAL EPITHELIUM IN MICE (Mus Musculus) EXPOSED TO MSG

Protective effects of alpha stone on monosodium glutamate-induced uterine hyperplasia in female wistar rats

Rhodamine B induces oxidative stress and cervical epithelial cell proliferation in the uterus

Contact Info

Product

Resources

About