Combination therapy comprising irreversible electroporation and hydroxycamptothecin loaded electrospun membranes to treat rabbit VX2 subcutaneous cancer

Wang, Lizhe; Chang, Jian; Qu, Yaqin; Qiu, Renna

doi:10.1007/s10544-018-0336-y

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…They found that drug release from HCPT-loaded fiber membranes lasted for approximately seven days and well inhibited the growth of rabbit subcutaneous VX2 tumors. 185 Luo et al emulsion prepared core-sheath structured fibers with core-loaded HCPT by electrostatic spinning. In vitro and in vivo antitumor efficacy assays showed that HCPT-loaded fibers showed superior in vivo antitumor activity and fewer side effects than free HCPT.…”

Section: Organic Npsmentioning

confidence: 99%

“…In vitro and In vivo [183] Electrospun fibers-based NPs Chemotherapy In vivo [185,192] Chemotherapy In vitro and In vivo [186][187][188]190] Polysaccharide-based (Chitosan) NPs Chemotherapy In vitro [197,199] Chemotherapy In vitro and In vivo [198,[201][202][203] Chemotherapycombined with Gas Therapy In vitro and In vivo [ In vivo [284] Chemotherapy In vitro and In vivo [281,282,285,286] Chemotherapy combined with PDT In vitro and In vivo [278,279] https://doi.org/10.2147/IJN.S377149…”

Section: Chemotherapymentioning

confidence: 99%

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Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Chen¹,

Wang²,

Wang³

et al. 2022

IJN

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10-Hydroxycamptothecin (HCPT) is a natural plant alkaloid from Camptotheca that shows potent antitumor activity by targeting intracellular topoisomerase I. However, factors such as instability of the lactone ring and insolubility in water have limited the clinical application of this drug. In recent years, unprecedented advances in biomedical nanotechnology have facilitated the development of nano drug delivery systems. It has been found that nanomedicine can significantly improve the stability and water solubility of HCPT. NanoMedicines with different diagnostic and therapeutic functions have been developed to significantly improve the anticancer effect of HCPT. In this paper, we collected reports on HCPT nanomedicines against tumors in the past decade. Based on current research advances, we dissected the current status and limitations of HCPT nanomedicines development and looked forward to future research directions.

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Section: Organic Npsmentioning

confidence: 99%

Section: Chemotherapymentioning

confidence: 99%

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Chen¹,

Wang²,

Wang³

et al. 2022

IJN

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“…Very recent studies started matching these two systems to investigate their potentialities if applied together. In 2018, Wang et al [ 171 ] loaded hydroxycamphothecin (HCPT) on an electrospun membrane to treat VX2 subcutaneous cancer of rabbits together after being ablated through IEP. The results were promising, since they showed a tumor inhibition rate more than 80%, while the system with only electroporation or the one only with drug membrane manifested a tumor inhibition rate of 62% and 38%, respectively.…”

Section: Transdermal Delivery Systems Stimuli-responsivementioning

confidence: 99%

Electromagnetically Stimuli-Responsive Nanoparticles-Based Systems for Biomedical Applications: Recent Advances and Future Perspectives

2021

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Nanoparticles (NPs) in the biomedical field are known for many decades as carriers for drugs that are used to overcome biological barriers and reduce drug doses to be administrated. Some types of NPs can interact with external stimuli, such as electromagnetic radiations, promoting interesting effects (e.g., hyperthermia) or even modifying the interactions between electromagnetic field and the biological system (e.g., electroporation). For these reasons, at present these nanomaterial applications are intensively studied, especially for drugs that manifest relevant side effects, for which it is necessary to find alternatives in order to reduce the effective dose. In this review, the main electromagnetic-induced effects are deeply analyzed, with a particular focus on the activation of hyperthermia and electroporation phenomena, showing the enhanced biological performance resulting from an engineered/tailored design of the nanoparticle characteristics. Moreover, the possibility of integrating these nanofillers in polymeric matrices (e.g., electrospun membranes) is described and discussed in light of promising applications resulting from new transdermal drug delivery systems with controllable morphology and release kinetics controlled by a suitable stimulation of the interacting systems (nanofiller and interacting cells).

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“…Recently, Chen et al 28 loaded the CPT containing Janus nanoparticles into the electrospun fibers and demonstrated the antitumor efficacy. Wang et al 29 reported that the CPT loaded electrospun membrane could release CPT constantly to damage the residual cancer cells after ablating tumor cells by irreversible electroporation. Faralli et al 30 prepared EGCG loaded electrospun fibers while the results of Caco-2 cells culture experiments suggested the fibers could inhibit the efflux transporters and decrease viability of cells.…”

Section: Introductionmentioning

confidence: 99%

Dual epigallocatechin gallate and camptothecin loaded electrospun meshes for synergy combination chemotherapy of colon cancer

Duan

et al. 2021

J of Applied Polymer Sci

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Combination chemotherapy based on electrospun fibrous was a promising strategy to applied synergy effects in treatment for colon cancer. Herein, Lactic acid/glycolic acid (PLGA) meshes with different ratios of epigallocatechin gallate (EGCG) and camptothecin (CPT) were manufactured. Results of X‐ray diffraction (XRD) revealed both EGCG and CPT were amorphous in meshes. Drug release experiments indicated that EGCG and CPT could be released sustainably while the dual drug‐loaded meshes had a higher release rate than single drug‐loaded meshes. Importantly, these meshes displayed obvious cytotoxicity against CT‐26 cells in anti‐colon cancer experiments, and the combination index values of all dual drug‐loaded meshes were around 0.5, suggesting strong synergy effect of EGCG and CPT. These results showed dual EGCG and CPT loaded meshes had application potential in effective synergistic therapy for colon cancer.

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Combination therapy comprising irreversible electroporation and hydroxycamptothecin loaded electrospun membranes to treat rabbit VX2 subcutaneous cancer

Cited by 6 publications

References 20 publications

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Electromagnetically Stimuli-Responsive Nanoparticles-Based Systems for Biomedical Applications: Recent Advances and Future Perspectives

Dual epigallocatechin gallate and camptothecin loaded electrospun meshes for synergy combination chemotherapy of colon cancer

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