Combination therapy of natural human interferon‐beta and ribavirin for chronic hepatitis <scp>C</scp> patients with injection drug use

Morikawa, Hiroyasu; Kozuka, Ritsuzo; Fujii, Hideki; Iwai, Shuji; Enomoto, Masaru; Tamori, Akihiro; Saito, Shinobu; Kawada, Norifumi

doi:10.1111/hepr.12066

Cited by 3 publications

(4 citation statements)

References 27 publications

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“…Previous studies reported that HCV‐2 or 3, but not HCV‐1, was prevalent among PWID in the main islands of Japan . These data suggest that HCV‐2/3 infection occurred by another distribution channel of illegal drugs in the main islands of Japan.…”

Section: Discussionmentioning

confidence: 65%

“…Furthermore, we speculate that IDU might have been the driving Previous studies reported that HCV-2 or 3, but not HCV-1, was prevalent among PWID in the main islands of Japan. [40][41][42][43][44] These data Although the MSM population was not included in our study, it has been reported that the number of HIV cases among MSM has increased in Okinawa. 48 The HCV transmission network among MSM is international 45,49,50 and MSM tourists visit Okinawa from other areas in Japan or overseas.…”

Section: Discussionmentioning

confidence: 92%

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Phylogenetic and phylodynamic analyses of hepatitis C virus subtype 1a in Okinawa, Japan

Hoshino

Sugiyama

Date

et al. 2018

Journal of Viral Hepatitis

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Okinawa Island, located in Southern Japan, has a higher prevalence rate of hepatitis C virus subtype 1a (HCV-1a) infection than that in mainland Japan. Okinawa has a history of US military occupation after World War II. To elucidate the transmission history of HCV-1a in Okinawa, 26 whole-genome sequences were obtained from 29 patients during 2011-2016. Phylogenetic trees were reconstructed to identify the origin and characteristics of HCV-1a in Okinawa with epidemiological information. A phylogenetic tree based on whole-genome sequencing revealed that all of the samples were located below the US branches. Additionally, we identified one cluster comprised of 17 strains (Okinawa, n = 16; United States, n = 1). The majority of the patients in this cluster were people who inject drugs (PWID), indicating the presence of a people who inject drugs (PWID) cluster. Subsequently, Bayesian analyses were employed to reveal viral population dynamics. Intriguingly, a phylodynamic analysis uncovered a substantial increase in effective population size of HCV-1a from 1965 to 1980 and a slight increase in mid-2000, which were associated with an increase in illicit drug use in Okinawa. The estimated divergence time of the PWID cluster was 1967.6 (1964.2-1971.1). These findings suggest that HCV-1a was introduced into Okinawa from the United States in the late 1960s, coincident with the Vietnam War. Subsequently, HCV-1a might have spread among the Japanese population with the spread of injecting drug use. Our study provides an understanding of HCV transmission dynamics in Okinawa, as well as the key role of PWID in HCV transmission.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 92%

Phylogenetic and phylodynamic analyses of hepatitis C virus subtype 1a in Okinawa, Japan

Hoshino

Sugiyama

Date

et al. 2018

Journal of Viral Hepatitis

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“…G1b, 31 %; Others: G2, G4, G5 [72,[103][104][105][106][107][108][109][110][111] CC/CT/TT-61.1/30.5/ 8.4, [112] Japan 127. 29 [115] 1.5-2.0 (1-2 %) [116,117] Blood transfusion (before 1992) [118][119][120], tattooing [121], intravenous drug abuser [122], needle stick [123] G1b, 70 %; G2a, 20 %; G2b, 10 % [126][127][128] 70-80/20-30 [132] Turkey 74.526 [192] 0.4-1.0 [193,194] Surgery, blood transfusion [195] G1b, 84 %; G1a, 10 %; G2, 3 %; G3, 1 %; G4, 1 % [196,197] 50 -31 [198] a,b…”

Section: Bangladesh Prevalence Of Hcv Infectionmentioning

confidence: 99%

“…Tattooing and illegal intravenous drug users are at risk of HCV infection in Japan as well as in other countries [121,122]. Although an effective vaccine against HCV is not available at present, HCV infections from needle sticks during health care procedures including persons with medical and dental activities [123], mother-to-child transmission [124] and transmission between husband and wife [125] are occasionally reported.…”

Section: Risk Factors Of Hcv Infectionmentioning

confidence: 99%

Features of hepatitis C virus infection, current therapies and ongoing clinical trials in ten Asian Pacific countries

et al. 2015

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Estimated hepatitis C virus (HCV) infection rates in the general populations were 1.3, 0.9, 0.4-1.0, 14.7, 0.1-0.3, 0.9-1.9, 1.0-2.0, 5, 4.4-8.6 and 0.5-1.3 % in Australia, Bangladesh, Mainland China, Egypt, Hong Kong, India, Japan, Pakistan, Taiwan and Turkey, respectively. The main HCV genotypes (Gs) are G1, G3, G1b, G4, G1b, G3, G1b, G3, G1b and G2, and G1 in Australia, Bangladesh, Mainland China, Egypt, Hong Kong, India, Japan, Pakistan, Taiwan and Turkey, respectively. Of IL28B genotypes, favorable alleles are ~50 % in Australia and Turkey, but 60-70 % in most of the other Asian countries. Peginterferon plus ribavirin is available in all ten Asian Pasific countries. In addition, HCV NS3/4A protease inhibitors with peginterferon plus ribavirin are currently available in several countries. Clinical trials of interferon-free regimens for HCV are ongoing in most of the ten Asian Pacific countries.

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Surgical Outcomes in Hepatitis C Virus-Related Hepatocellular Carcinoma: Special Reference to Sustained Virological Responses to Interferon Therapy

Tanaka

Tamori

Takemura

et al. 2017

The American Surgeon™

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Long-term surgical outcomes after hepatic resection for hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) in patients who achieved a sustained virological response (SVR) to interferon (IFN) therapy remain inconclusive. Clinical records of 277 patients who underwent hepatic resection for HCV-related early stage HCC (met the Milan criteria) between 1993 and 2012 were retrospectively reviewed. Thirty-seven patients achieved the SVR during HCC detection (pre-SVR group), whereas 23 achieved SVR using adjuvant interferon therapy after hepatic resection (post-SVR group). The control group included remaining 217 patients. We investigated the SVR effects on surgical outcomes. Disease-free survival (DFS) rates at 5/10/15 years after hepatic resection were significantly greater in the pre and post-SVR groups than in the control group (46/30/30per cent and 61/36/27 per cent vs 23/7/7 per cent, respectively; P < 0.001). Overall survival (OS) rates at 10/15 years after hepatic resection were better in the pre- and post-SVR groups than in the control group (68/68 percent and 78/78 per cent vs 13/11 per cent, respectively; P < 0.001). On multivariate analysis, pre- and post-SVR were independent factors for no recurrence (pre-SVR: hazard ratio (HR), 0.48, P = 0.002; post-SVR: HR, 0.41, P = 0.001) and improved survival (pre-SVR: HR, 0.36, P = 0.002; post-SVR: HR, 0.122, P < 0.001). Achievement of SVR in patients with HCV-related HCC was associated with long-term disease-free survival and OS after hepatic resection.

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Combination therapy of natural human interferon‐beta and ribavirin for chronic hepatitis C patients with injection drug use

Abstract: IFN-β/RBV combination therapy is useful for treating IDU.

Cited by 3 publications

References 27 publications

Phylogenetic and phylodynamic analyses of hepatitis C virus subtype 1a in Okinawa, Japan

Phylogenetic and phylodynamic analyses of hepatitis C virus subtype 1a in Okinawa, Japan

Features of hepatitis C virus infection, current therapies and ongoing clinical trials in ten Asian Pacific countries

Surgical Outcomes in Hepatitis C Virus-Related Hepatocellular Carcinoma: Special Reference to Sustained Virological Responses to Interferon Therapy

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