Combination therapy of sirolimus and acitretin in solid organ transplant recipients: a new cutaneous adverse event

Skillen, Laura A.; Corry, A.

doi:10.1111/ced.13822

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Retinoids have multiple pharmacological activities including anti-inflammatory and apoptotic effects, besides inhibition of tumor promotion [ 96 , 97 ]. Remarkably, retinoic acid (RA) hinders IL-6, IL-21, and IL-23 signaling that results in blocking the differentiation of naïve T cells to Th17 cells [ 98 ].…”

Section: Drugs That Might Affect the Cytokines Storm In Covid-19mentioning

confidence: 99%

Promising drug repurposing approach targeted for cytokine storm implicated in SARS-CoV-2 complications

Shawki

Elsayed

Mantawy

et al. 2021

Immunopharmacology and Immunotoxicology

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A global threat has emerged in 2019 due to the rapid spread of Coronavirus disease (COVID-19). As of January 2021, the number of cases worldwide reached 103 million cases and 2.22 million deaths which were confirmed as the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). This global pandemic galvanized the scientific community to study the causative virus (SARS-CoV2) pathogenesis, transmission, and clinical symptoms. Remarkably, the most common complication associated with this disease is the cytokine storm which is responsible for COVID-19 mortality. Thus, targeting the cytokine storm with new medications is needed to hamper COVID-19 complications where the most prominent strategy for the treatment is drug repurposing. Through this strategy, several steps are skipped especially those required for testing drug safety and thus may help in reducing the dissemination of this pandemic. Accordingly, the aim of this review is to outline the pathogenesis, clinical features, and immune complications of SARS-CoV2 in addition to suggesting several repurposed drugs with their plausible mechanism of action for possible management of severe COVID-19 cases.

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Section: Drugs That Might Affect the Cytokines Storm In Covid-19mentioning

confidence: 99%