Combination Therapy with Anti-VEGF and Intravitreal Dexamethasone Implant for Macular Edema Secondary to Retinal Vein Occlusion

Abstract

Methodspatients with macular edema secondary to retinal vein occlusion who visited our hospital from August 2020 to August 2022 were enrolled. The patients were randomized into the ranibizumab group and the combination group (ranibizumab combined with dexamethasone intravitreal implant). The patients in both groups received ranibizumab intravitreal injections in the rst three months as the initial treatment. However, in the ranibizumab group, patients might receive repeat injections during the follow-up in case of the recurrence of macular edema; in the combination group, patients received an intravitreal injection of dexamethasone implant after the rst injection of ranibizumab at the day 15. The main outcome evaluations are best-corrected visual acuity and reduction of central macular thickness. The secondary outcome evaluations are the numbers of recurrence, the average injection interval, and the number of injections. Adverse events, such as ocular hypertension, and subconjunctival hemorrhage were also recorded. Results44 eyes were assigned to the ranibizumab group (n = 23) and the combination group (n = 21). Compared with the ranibizumab group, the combination group showed a signi cantly greater improvement in bestcorrected visual acuity at 1, 3, 6, and 12 months postoperatively. Both groups showed a decrease in central macular thickness at 1 week and 1, 3, 6, and 12 months, compared with the baseline (P < 0.05). However, the combination group did not exhibit higher central macular thickness-reducing effects than the ranibizumab group (P > 0.05). Compared with the ranibizumab group, the combination group required a signi cantly lower average number of injections (P = 0.011) and had a signi cantly lower number of macular edema recurrences (P < 0.001) and signi cantly prolonged average time to re-injection (P = 0.05). The incidence of adverse events was not signi cantly different between the two groups (P = 0.944).