Combination treatment in asthma: Reviewing old and new options

Papi, Alberto; Cazzola, Mario

doi:10.1016/j.pupt.2015.08.010

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…Therefore, new therapeutic strategies that would help interrupt this vicious circle are necessary. Whereas inflammation remains the primary target of asthma therapies [ 6 , 7 ], these therapies have a negligible effect on structure and hardly attenuate the structural changes in asthmatic airways [ 8 , 9 ]. This problem underlies the need for elaboration of new therapeutic approaches that directly target the pro-fibrotic processes, including the fibroblast–myofibroblast transition (FMT).…”

Section: Introductionmentioning

confidence: 99%

Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization

Paw

Wnuk

Kądziołka

et al. 2018

IJMS

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The activation of human bronchial fibroblasts by transforming growth factor-β1 (TGF-β1) leads to the formation of highly contractile myofibroblasts in the process of the fibroblast–myofibroblast transition (FMT). This process is crucial for subepithelial fibrosis and bronchial wall remodeling in asthma. However, this process evades current therapeutic asthma treatment strategies. Since our previous studies showed the attenuation of the TGF-β1-induced FMT in response to lipid-lowering agents (e.g., statins), we were interested to see whether a corresponding effect could be obtained upon administration of hypolipidemic agents. In this study, we investigated the effect of fenofibrate on FMT efficiency in populations of bronchial fibroblasts derived from asthmatic patients. Fenofibrate exerted a dose-dependent inhibitory effect on the FMT, even though it did not efficiently affect the expression of α-smooth muscle actin (α-SMA; marker of myofibroblasts); however, it considerably reduced its incorporation into stress fibers through connexin 43 regulation. This effect was accompanied by disturbances in the actin cytoskeleton architecture, impairments in the maturation of focal adhesions, and the fenofibrate-induced deactivation of TGF-β1/Smad2/3 signaling. These data suggest that fenofibrate interferes with myofibroblastic differentiation during asthma-related subepithelial fibrosis. The data indicate the potential application of fenofibrate in the therapy and prevention of bronchial remodeling during the asthmatic process.

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Section: Introductionmentioning

confidence: 99%

Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization

Paw

Wnuk

Kądziołka

et al. 2018

IJMS

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“…In addition, adverse effects are common in most patients due to long-term administration, such as glucose intolerance, dysphonia [11], and a reduction in bone mineral density [12]. Over the past decades, emerging combination therapies have offered further advantages compared to GCs alone [13]. For example, the dry powder of budesonide + formoterol fumarate dehydrate is one of the most widely used fixed combinations for asthma control.…”

Section: Introductionmentioning

confidence: 99%

Supplementation with Tetrahydrocurcumin Enhances the Therapeutic Effects of Dexamethasone in a Murine Model of Allergic Asthma

Chen

Qin

et al. 2020

Int Arch Allergy Immunol

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Background: Tetrahydrocurcumin (THC) is the major active metabolite of curcumin, which is a dietary factor derived from Curcuma species. Our previous study demonstrated a significant beneficial effect of THC in mice with allergic asthma. Glucocorticosteroids (GCs) are commonly used drugs in asthma. Whether THC supplementation could promote the beneficial effects of GC therapy on asthma has not yet been reported. The current study aimed to investigate the combined efficacy of GC and THC treatment in a mouse model of allergic asthma. Methods: BALB/c mice were randomly divided into 5 groups: the control group, ovalbumin (OVA)-induced group, and OVA-induced mice treated with dietary THC only, intraperitoneal injection of dexamethasone (DEX) only, or THC combined with DEX. The nasal symptoms, histopathological alterations of lung tissues, lung cytokine production, and Th cell subsets were assessed. Results: THC or DEX had beneficial effects on nasal symptoms and pathological lung changes, and the therapeutic effects between THC and DEX treatment were comparable. Importantly, compared to the monotherapy groups (THC or DEX only), the combination of THC and DEX showed a significantly reduced nasal rubbing frequency, lower mucus hyperproduction, lower Th2 and Th17 cell numbers as well as lower related cytokine levels (IL-4, IL-5, and IL-17A). Conclusions: Supplementation with THC can enhance the therapeutic effects of DEX to alleviate airway symptoms, lung inflammation, and the Th2 response. Our findings suggest that dietary administration of THC could act as an add-on therapy for asthma treated with GCs.

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Trattamento non farmacologico dell’asma negli adulti per il fisioterapista

Everard

Reychler

2017

EMC - Medicina Riabilitativa

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Combination treatment in asthma: Reviewing old and new options

Cited by 5 publications

References 34 publications

Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization

Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization

Supplementation with Tetrahydrocurcumin Enhances the Therapeutic Effects of Dexamethasone in a Murine Model of Allergic Asthma

Trattamento non farmacologico dell’asma negli adulti per il fisioterapista

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