Combination vaccines in the South African setting

Visser, A T; Hoosen, Anwar A.

doi:10.1016/j.vaccine.2012.05.001

Cited by 4 publications

(4 citation statements)

References 57 publications

(56 reference statements)

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“…However, combination vaccines are usually more expensive than the individual vaccines that can be used to obtain the same level of immunization [26].…”

Section: Literature Reviewmentioning

confidence: 99%

Buying vaccines through a single payment as a proxy for procuring vaccines via formularies

Alves-Maciel

2022

Preprint

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In this study, we evaluate the possibility of making vaccines more affordable without impacting profits by exploring the effects of selling vaccines as formularies or baskets of vaccines bundled in the same sale. Assuming that countries are grouped into market segments for tiered pricing purposes and are coordinated by a single decision-maker, we propose selling vaccines as formularies by changing their pricing scheme so that buyers make a single lump-sum payment to each vaccine producer for their vaccines. Results show that changing the pricing scheme can improve affordability.

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“…However, combination vaccines are usually more expensive than the individual vaccines that can be used to obtain the same level of immunization [26].…”

Section: Literature Reviewmentioning

confidence: 99%

Buying vaccines through a single payment as a proxy for procuring vaccines via formularies

Alves-Maciel

2022

Preprint

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“…However, isolated cases were still reported, which mainly affected the very young. 12,13 The National Expanded Programme for Immunisation (EPI) was established in South Africa in 1995, and included the DTwP vaccine to be administered at 6, 10 and 14 weeks, with a booster at 18 months of age.…”

Section: Introductionmentioning

confidence: 99%

“…13,14 Well documented surveillance activities in the USA and Europe show an increasing incidence of pertussis in the adolescent and adult populations, despite a decreasing incidence in childhood. South Africa has experienced a steadily increasing number of laboratory-confirmed pertussis cases in recent years, according to the National Institute for Communicable Diseases (NICD).…”

Section: Introductionmentioning

confidence: 99%

“…Poorer communities classically have lower vaccine coverage rates and reduced timeliness. 13 However, despite vaccine coverage of 81-93% in areas of the Western Cape in the late 1980s, a pertussis outbreak was reported in Cape Town in 1988 and 1989. 12 Although no outbreaks have been reported since, data from the NICD indicated an increasing number of laboratory-confirmed pertussis cases in South Africa between 2008 and 2011, in line with international trends.…”

Section: Introductionmentioning

confidence: 99%

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The seroprevalence ofBordetella pertussisantibodies in adolescents in the Western Cape

Rensburg

Esser

Beer

2013

Southern African Journal of Epidemiology and Infection

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South Afr J Epidemiol InfectOriginal Research: The seroprevalence of Bordetella pertussis antibodies in adolescents in the Western Cape Pertussis is a highly contagious respiratory disease that can occur in all age groups. Over the past 15 years, an increase in the incidence of reported cases has been observed globally. Local surveillance data have also shown an increase in the number of laboratory-confirmed cases. This raises concerns about waning immunity in adolescents and adults. The aim of this study was to screen for seropositivity against pertussis infection by measuring immunoglobulin G (IgG) antibody titers of Bordetella pertussis in an adolescent population in the Western Cape, South Africa. Serum samples were collected from 182 adolescents aged 15-18 years from different racial groups. The SERION ELISA ® classic B. pertussis IgG assay was used to detect human antibodies in serum. Twenty-seven subjects (15%) were seronegative and 135 (74%) seropositive for IgG antibodies. Racial breakdown showed that 84% of the black, 74% of the coloured, and 69% of the white subjects were seropositive, while the largest percentage (24%) of sero-negative individuals was in the white population group. This study demonstrated a high percentage of individuals in the adolescent age group with sero-positive antibody levels. However, it is unknown if these antibody levels are functionally protective. A more rigourous surveillance system would assist in defining and understanding the epidemiology of pertussis in South Africa, and could provide evidence of the need for booster vaccinations in adolescence and adulthood.Peer reviewed.

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