Combinations

Dantas, Leticia Mattos de Souza; Crowell‐Davis, Sharon L.; Ogata, Niwako

doi:10.1002/9781119226253.ch19

Cited by 3 publications

(1 citation statement)

References 47 publications

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“…Intranasal administration of midazolam (0.2 mg/kg) determines a good and quick sedation (effect in 3-4 minutes) [43]. With a reduced frequency in use, they are also cited Flurazepam 2 mg/kg IV [44] and Lorazepam 0.1 mg/kg [15]. Flumazenil 0.02-0.08 mg/kg is a selective benzodiazepine antagonist reversal agent that can be used to counteract the effects of benzodiazepines in cases of overdose or adverse reactions [26,45].…”

Section: Benzodiazepinesmentioning

confidence: 99%

Pig Sedation and Anesthesia for Medical Research

Costea,

Ene,

Pavel

2023

Preprint

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Anesthesia ensures the welfare of the animal, enables safe and effective procedures, and allows accurate data collection [1]. In clinical veterinary practice, proper training and expertise in anesthesia administration and monitoring are essential. Pigs are commonly used in medical and scientific research as models for studying various aspects of human health, physiology, and disease due to their physiological and anatomical similarities to humans [2–4]. Pigs are suitable experimental animals for many surgery techniques because they are similar in size to humans and have a short reproductive cycle. This makes them ideal for research concerning organ transplantation, cardiovascular surgery, and other procedures that require a large animal model. Pigs also have a similar anatomy to humans, which makes them a good choice for studying diseases and developing new treatments [5]. Sedation and premedication should be administered at the lowest dose to be effective with predictable results and reduced adverse effects, to ensure the safety of both the animal and the team involved in the procedure, with a fast onset and optimizing the induction and maintenance of anesthesia. The goal of induction is to achieve a safe and effective level of anesthesia that ensures the patient's safety and facilitates the research. Most of the time, inhalation anesthesia with endotracheal intubation is the ideal choice for maintenance., allowing efficient anesthetic management. The difficulties related to the endotracheal intubation of pigs can be overcome by knowing the anatomical peculiarities related to the species and the multiple methods cited in the literature. Effective analgesia tailored to the specific procedure, the pig's condition, and individual responses to medications should complete the maintenance and recovery protocols, reducing perioperative complications.

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