Combinations of radiotherapy with immunotherapy in cervical cancer

Abstract

Immunotherapy serves as another effective cancer treatment apart from surgery, chemoradiotherapy, and targeted drug therapy. Radiotherapy combined with immunotherapy has significantly improved the effective cure rate for patients in several clinical trials. It subverted the traditional view that radiotherapy kills immune cells and has immunosuppressive effects, indicating a synergistic effect of radiotherapy and immunotherapy. In this article, we reviewed and summarized the molecular mechanism of the combined use of radiotherapy and immunotherapy, as well as the clinical treatment and safety of the combination of the two. We describe the rationale for the integration of radiotherapy and immunotherapy in patients with cervical cancer, present safety and efficacy data that support this combination strategy, and highlight unanswered question sand future research needs. Besides, this study can be referenced for clinicians to guide subsequent clinical medicine.

Common Predictors of cervical cancer related mortality in Ethiopia. A systematic review and Meta-analysis

“…The reason for this could be that, while surgical therapy is determined by tumour size and cancer stage, different evidence strongly suggests surgery to reduce tumour size and remove partial if all impossible. Adjuvant therapy is then used to reduce the rate of anaplasia and thus the cancer cell's invasive capacity [43,44].…”

Immunotherapy: cancer immunotherapy and its combination with nanomaterials and other therapies

“…It overturns the conventional opinion that RT destroys immune cells and possesses an immunosuppressive effect, and demonstrates the synergy of RT with immunotherapy. 214 As a trigger for the systemic anti-tumor immune response, RT can be used as a radical and systemic therapy with the help of immunotherapy and added to the current standard regimen for the metastatic cancer patients. 215 It has been reported in case reports of various cancer types that there are benefits of RT in combination with immunotherapy.…”

Review Article: Immune Landscape and Immunotherapy Options in Cervical Carcinoma

“…Moreover, the combination of radiation therapy with CTLA-4 and PD-1 stimulate the non-redundant immune response in cancer patients [ 47 ]. According to another study, the combination immunotherapy consisting of a low dose of nanomicelle-loaded paclitaxel and anti-PD-1 increased the infiltration of DCs and T cells at the tumor site and showed immune-dependent control of the tumor in cervical cancer patients [ 48 ]. Significant clinical activity in cervical cancer patients was reported when patients were treated with the combination of a PD-L1- and CTLA4-blocking moAb nivolumab and ipilimumab, respectively.…”