Combinations of the effect of radiotherapy, alkylating agents and phytohemagglutinin on Sarcoma 180 in Swiss mice

Robinson, E.; Mekori, T.

doi:10.1016/0014-2964(73)90081-9

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1973

1974

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“…The use of PHA as a nonspecific stimulator of the immune system is supported by our finding [8], that it prolongs the survival of tumor-bearing animals and decreases tumor growth. Further studies are being done now in our laboratory to check the effect of PHA alone or with combination of other methods of treatment on different tumors.…”

Section: Discussionsupporting

confidence: 59%

The Effect of Phytohaemagglutinin on the Antibody Response in Mice Bearing Ascites Tumor

Mekori¹,

Robinson²

1973

Oncology

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The antibody response to sheep erythrocytes was examined in normal mice and in mice with ascites tumor. Antigen stimulation from day 0 to day 7 after tumor transplantation was associated with a decreased immune response. From day 7 onward, no immune response occurred. PHA injection before antigen administration depressed the immune response, whereas PHA injection after antigen administration enhanced the immune response. Intraperitoneal administration of PHA caused a greater decrease in tumor volume. Further studies on the effect of PHA alone and in conjunction with other methods of therapy are being carried out at present.

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Section: Discussionsupporting

confidence: 59%