Throughout its history, materials science has been accomplished with the explicit or implicit backdrop that materials can be improved for human use. To a considerable extent, this milieu has governed the systems considered by the discipline, and the kinds of knowledge materials scientists generate. This technological undercurrent accounts for a thread common to materials science since its earliest days, which is study of complex systems. For example, our understanding of multicomponent phase thermodynamics, would arguably not be as advanced, nor as deep, as it is today without the desire to produce improved metallurgical alloys. Certainly, this technological interplay with complexity could be restated for any number of historical cases and accomplishments across the materials science spectrum -from doped semiconductors to polymer blends. This trend continues for today's materials scientists, as we strive to understand, and to use, increasingly complex materials systems. In this respect, the discovery, development, and optimization of today's new materials are met by three interrelated challenges (Figure 1). First, advanced materials are often highly tailored, meaning that composition, structure and properties are optimized to meet a specific application. For example, materials for fuel cell membranes[1] must transport specific ions, and they must also be structurally sound, chemically resistant, and amenable to processing. Given