Combinatorial chemistry of hydantoins

One‐pot synthesis of [11C]ureas via triphenylphosphinimines

“…Although not explored in this paper, it is obvious that other variations on the presented method may be possible as well. For example, the application of resin-bound triphenylphosphinimines, 27 subjection of amines on solid support 31,32 to the intermediate [ 11 C]isocyanate, as well as the use of a wide range of other nucleophiles that can lead to compounds other than ureas (i.e. thiols, [33][34][35] alkynes, 36,37 or alcohols/acids [38][39][40][41] ).…”

(S)-5-Benzylimidazolidine-2,4-dione monohydrate

“…Imidazolidine-2,4-dione, or hydantoin, is a ®ve-membered heterocyclic ring containing a reactive cyclic urea nucleus. This heterocycle represents a signi®cant molecular template in combinatorial chemistry libraries (Boeijen et al, 1998;Park et al, 2001), principally because of the four possible substitution points. Solid-phase syntheses including hydantoin as a starting building block have been reported recently (Ganesan, 2003;Va  zquez et al, 2004;Alsina et al, 2005).…”

Synthesis, NMR analysis and applications of isotope-labelled hydantoins

“…The chemical properties, methods of synthesis and reactivity of hydantoin and its derivativies have been reviewed extensively [10][11][12][13][14][15]. For synthetic chemistry applications, hydantoin is a useful centre in combinatorial chemistry [16], multicomponent reactions [17,18] and in diversity-oriented synthesis [19][20][21]. Hydantoins substituted at the 5-position are precursors to optically pure natural and unnatural α-amino acids, which is achieved through their chemical or enzymatic hydrolysis [22][23][24][25][26][27][28][29][30].…”