2008
DOI: 10.1186/1471-2164-9-601
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Combinatorial control of gene expression by the three yeast repressors Mig1, Mig2 and Mig3

Abstract: Background: Expression of a large number of yeast genes is repressed by glucose. The zinc finger protein Mig1 is the main effector in glucose repression, but yeast also has two related proteins: Mig2 and Mig3. We have used microarrays to study global gene expression in all possible combinations of mig1, mig2 and mig3 deletion mutants.

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Cited by 92 publications
(102 citation statements)
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References 72 publications
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“…Mig1-binding sites (AATGCGGGGK or SYGGGG) are not found upstream of the filamentation target genes MSB2, KSS1, PGU1, SVS1, YLRO42C, STE12, and TEC1, which might suggest that simply switching these proteins from repressors to activators cannot explain the change in the function of these proteins. DNA microarray data on genes upregulated by Mig1 and Mig2 does not include filamentous growth pathway regulators (Westholm et al 2008). Nevertheless, Mig1 and Mig2 may modulate nutritional scavenging by repression of GAL/ SUC and other genes in the nucleus.…”
Section: Mig1 and Mig2 Proteins Connect Glucose Signaling To Mapk Regmentioning
confidence: 99%
See 1 more Smart Citation
“…Mig1-binding sites (AATGCGGGGK or SYGGGG) are not found upstream of the filamentation target genes MSB2, KSS1, PGU1, SVS1, YLRO42C, STE12, and TEC1, which might suggest that simply switching these proteins from repressors to activators cannot explain the change in the function of these proteins. DNA microarray data on genes upregulated by Mig1 and Mig2 does not include filamentous growth pathway regulators (Westholm et al 2008). Nevertheless, Mig1 and Mig2 may modulate nutritional scavenging by repression of GAL/ SUC and other genes in the nucleus.…”
Section: Mig1 and Mig2 Proteins Connect Glucose Signaling To Mapk Regmentioning
confidence: 99%
“…Specifically, five isolates of Ste50, five isolates of Mig1, and one isolate of Mtc1 were identified. Mig2 is a homolog of Mig1 (Lutfiyya and Johnston 1996;Lutfiyya et al 1998;Westholm et al 2008). Mig2 was not identified in the screen but associated with the cytosolic domain of Opy2 by two-hybrid analysis ( Figure 3B).…”
Section: Mig1 and Mig2 Proteins Interact With Opy2mentioning
confidence: 99%
“…Eds1 is the closest homolog of Rgt1, also a repressor, which regulates glucose transporters. The promoter of EDS1 contains a significant binding site for Mig1/Mig2, major enforcers of glucose repression whose targets also include glucose transporters, and EDS1 is differentially expressed in the mig1, mig2 double mutant but not in either single mutant (Westholm et al 2008). Thus, Eds1 may link lysine biosynthesis to glucose availability and the fermentative/oxidative balance.…”
Section: Identifying Novel Tf Functionsmentioning
confidence: 99%
“…However, the reduced expression of these genes is likely an indirect effect caused by repression of this set of genes by Mig2, a transcriptional repressor with DNA binding specificity similar to Mig1 (34), but whose expression increases when Rgt1-Mth1/Std1 is inactivated (14). The 15-fold higher levels of Mig2 that result when both MTH1 and STD1 are deleted may be causing reduced expression of this set of 60 genes, 19 of which are known targets of Mig1/Mig2 repression (35).…”
Section: Analysis Of Gene Expression Reveals An Overlap Of Targetsmentioning
confidence: 99%