Combinatorial Drug Therapy for Controlling <i>Pseudomonas aeruginosa</i> and Its Association With Chronic Condition of Diabetic Foot Ulcer

Srivastava, Prakhar; Karthikeyan, Sivashanmugam

doi:10.1177/1534734619873785

Cited by 19 publications

(11 citation statements)

References 137 publications

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“…39 The increased prevalence of MDR has been noted in different studies worldwide. 30,31,40,41 This can be attributed to extensive use of antibiotics, which gives a selective advantage for survival of pathogenic bacterial strains. MDR P. aeruginosa guarded by biofilms that are difficult to penetrate can survive and develop more resistance.…”

Section: Discussionmentioning

confidence: 99%

Diabetic Foot Ulcer Infections and Pseudomonas aeruginosa Biofilm Production During the COVID-19 Pandemic

Yakout¹,

Abdelwahab²

2022

J. Pure Appl. Microbiol.

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During the different waves of the coronavirus (COVID-19) pandemic, there has been an increased incidence of diabetes mellitus and diabetic foot infections. Among gram-negative bacteria, Pseudomonas aeruginosa is the predominant causative agent for diabetic foot ulcer infections in low-resource countries. P. aeruginosa possesses a variety of virulence factors, including biofilm formation. Biofilm formation is an important benchmark characteristic in the pathophysiology of diabetic foot ulceration. The main objective of the current study was to identify the most commonly isolated organisms and their antibiotic susceptibility patterns in diabetic foot patients during the COVID-19 pandemic. We also determined the genes associated with bacterial persistence and biofilm formation in the predominantly isolated organism. Accordingly, 100 wound swab samples were collected from diabetic foot patients from different hospitals in Alexandria, Egypt. Through phenotypic detection of biofilm formation, 93% (40) of the 43 P. aeruginosa isolates examined were categorized as biofilm producers. Molecular detection of the biofilm-encoding genes among the 43 P. aeruginosa isolates was as follows: algD (100%), pelF (88%) and pslD (49.7%), and this highlights a need for biofilm formation inhibitors to prevent the persistence of bacterial pathogens, and thus achieve better clinical outcomes in diabetic foot ulcer infections.

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Section: Discussionmentioning

confidence: 99%

Diabetic Foot Ulcer Infections and Pseudomonas aeruginosa Biofilm Production During the COVID-19 Pandemic

Yakout¹,

Abdelwahab²

2022

J. Pure Appl. Microbiol.

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“…A large number of staphylococci and streptococci are found in the environment [ 51 , 52 ]. Fastidious anaerobics (particularly, those belonging to the Clostridiales Genus XI), Corynebacterium spp., and Gram-negative rods are among the bacteria usually found in the same foot ulcers (namely, Klebsiella spp., Acinetobacter spp., Enterobacter spp., P. aeruginosa , and Escherichia coli ) [ 53 , 54 ].…”

Section: Infection Of Dfusmentioning

confidence: 99%

An Overview of Diabetic Foot Ulcers and Associated Problems with Special Emphasis on Treatments with Antimicrobials

Baig¹,

Banu

Zehravi

et al. 2022

Life

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One of the most significant challenges of diabetes health care is diabetic foot ulcers (DFU). DFUs are more challenging to cure, and this is particularly true for people who already have a compromised immune system. Pathogenic bacteria and fungi are becoming more resistant to antibiotics, so they may be unable to fight microbial infections at the wound site with the antibiotics we have now. This article discusses the dressings, topical antibacterial treatment, medications and debridement techniques used for DFU and provides a deep discussion of DFU and its associated problems. English-language publications on DFU were gathered from many different databases, such as Scopus, Web of Science, Science Direct, Springer Nature, and Google Scholar. For the treatment of DFU, a multidisciplinary approach involving the use of diagnostic equipment, skills, and experience is required. Preventing amputations starts with patient education and the implementation of new categorization systems. The microbiota involved in DFU can be better understood using novel diagnostic techniques, such as the 16S-ribosomal DNA sequence in bacteria. This could be achieved by using new biological and molecular treatments that have been shown to help prevent infections, to control local inflammation, and to improve the healing process.

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“…Studies have shown that acyl homoserine lactones (AHLs) regulate multiple factors during biofilm formation by Pseudomonas aeruginosa and play a fundamental role in regulating different genes involved in biofilm formation. Therefore, AHL can be used as a therapeutic target to provide a correct path for drug design targeting multidrug-resistant bacteria[ 73 ]. However, in practice, the abuse of antibiotics still frequently leads to the emergence of drug-resistant bacteria.…”

Section: Treatment Of Dfumentioning

confidence: 99%

Diabetic foot ulcer: Challenges and future

Yang¹,

Rong²,

Wu³

2022

World J Diabetes

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Diabetic foot ulcers (DFUs) have become one of the important causes of mortality and morbidity in patients with diabetes, and they are also a common cause of hospitalization, which places a heavy burden on patients and society. The prevention and treatment of DFUs requires multidisciplinary management. By controlling various risk factors, such as blood glucose levels, blood pressure, lipid levels and smoking cessation, local management of DFUs should be strengthened, such as debridement, dressing, revascularization, stem cell decompression and oxygen therapy. If necessary, systemic anti-infection treatment should be administered. We reviewed the progress in the clinical practice of treating DFUs in recent years, such as revascularization, wound repair, offloading, stem cell transplantation, and anti-infection treatment. We also summarized and prospectively analyzed some new technologies and measurements used in the treatment of DFUs and noted the future challenges and directions for the development of DFU treatments.

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Combinatorial Drug Therapy for Controlling Pseudomonas aeruginosa and Its Association With Chronic Condition of Diabetic Foot Ulcer

Cited by 19 publications

References 137 publications

Diabetic Foot Ulcer Infections and Pseudomonas aeruginosa Biofilm Production During the COVID-19 Pandemic

Diabetic Foot Ulcer Infections and Pseudomonas aeruginosa Biofilm Production During the COVID-19 Pandemic

An Overview of Diabetic Foot Ulcers and Associated Problems with Special Emphasis on Treatments with Antimicrobials

Diabetic foot ulcer: Challenges and future

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