2024
DOI: 10.1002/cmdc.202400145
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Combinatorial Libraries of Bipodal Binders of the Insulin Receptor

Irena Selicharová,
Benjamin Fabre,
María Soledad Garre Hernández
et al.

Abstract: The binding process of insulin to its transmembrane receptor entails a sophisticated interplay between two proteins, each possessing two binding sites. Given the difficulties associated with the use of insulin in the treatment of diabetes, despite its remarkable efficacy, there is interest in smaller and more stable compounds than the native hormone that would effectively activate the receptor. Our study adopts a strategy focused on synthesizing extensive combinatorial libraries of bipodal compounds consisting… Show more

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