Combinatorial Methods for Polymer Science

Meredith, Carson; Smith, A. P.; Crosby, Alfred J.; Amis, Eric J.; Karim, Alamgir

doi:10.1002/0471440264.pst069

Cited by 6 publications

(6 citation statements)

References 54 publications

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“…In materials science, the materials properties depend not only on composition, but also on morphology, microstructure, and other parameters that are related to the material-preparation conditions. As a result of this complexity, combinatorial and high-throughput (CHT) experimentation in materials science has been recognized as a new scientific approach to generate significant new knowledge as summarized in recent reviews and books. − …”

Section: Introductionmentioning

confidence: 99%

Combinatorial and High-Throughput Screening of Materials Libraries: Review of State of the Art

et al. 2011

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Rational materials design based on prior knowledge is attractive because it promises to avoid time-consuming synthesis and testing of numerous materials candidates. However with the increase of complexity of materials, the scientific ability for the rational materials design becomes progressively limited. As a result of this complexity, combinatorial and high-throughput (CHT) experimentation in materials science has been recognized as a new scientific approach to generate new knowledge. This review demonstrates the broad applicability of CHT experimentation technologies in discovery and optimization of new materials. We discuss general principles of CHT materials screening, followed by the detailed discussion of high-throughput materials characterization approaches, advances in data analysis/mining, and new materials developments facilitated by CHT experimentation. We critically analyze results of materials development in the areas most impacted by the CHT approaches, such as catalysis, electronic and functional materials, polymer-based industrial coatings, sensing materials, and biomaterials.

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Section: Introductionmentioning

confidence: 99%

Combinatorial and High-Throughput Screening of Materials Libraries: Review of State of the Art

et al. 2011

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“…Gradients provide convenient access to a large parameter space, tunable by the range and slope of property change along the sample. Methodologies have been developed for creating gradients in surface energy [12], film thickness and morphology [13][14][15], temperature [16] and composition [17]. While are continually required to measure material properties along these gradients.…”

Section: Introductionmentioning

confidence: 99%

“…In this manner, one loading and unloading cycle produces several adhesion tests and in a greater testing density than is possible with the traditional single-lens techniques. This is the motivation for the development of a multilens-contact adhesion test (MCAT) platform [16,19,20]. The MCAT technique, as will be shown, utilizes an array of hemispherical lenses to conduct multiple axisymmetric adhesion tests during one loading/unloading cycle.…”

Section: Introductionmentioning

confidence: 99%

A multilens measurement platform for high-throughput adhesion measurements

Forster

Zhang

Crosby

et al. 2004

Meas. Sci. Technol.

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Current high-throughput methodologies for measuring interfacial adhesion typically rely on serial or sequential testing of discrete or continuous libraries. We have developed a measurement platform that employs an array of micro-lenses to simultaneously measure adhesion at multiple points on a planar specimen library. This technique relies on the accurate measurement of the overall lens array displacement, rather than load and individual lens contact areas to quantify the work of adhesion using the Johnson, Kendall and Roberts (JKR) model. We demonstrate the ability of this technique to measure the work of adhesion (loading) and energy release rate (unloading) for a polydimethylsiloxane lens array against glass, and we compare our work of adhesion measurements to the traditional single-lens geometry. We find the work of adhesion measured with the multilens array is 18.9 mJ m −2 ± 9.4 mJ m −2 compared to 20 mJ m −2 ± 5 mJ m −2 for a single-lens experiment. Also, the micro-lens array deviates from the JKR model when the lens array displacement is comparable to lens height.

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“…In reality, gradient composition often varies in a more complex fashion because of the limited miscibility of the film components and/ or differences in their interactions with the substrate surface. Phase separation of the gradient components 23 and/or dewetting from the substrate 16 may occur under these circumstances. The extent to which phase separation and dewetting are manifested in the final gradients may be limited by silane reaction kinetics and thus is difficult to predict.…”

Section: ■ Gradient Propertiesmentioning

confidence: 99%

Organosilane Chemical Gradients: Progress, Properties, and Promise

Collinson

Higgins²

2017

Langmuir

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Chemical gradients play an important role in nature, driving many different phenomena critical to life, including the transport of chemical species across membranes and the transport, attachment, and assembly of cells. Taking a cue from these natural processes, scientists and engineers are now working to develop synthetic chemical gradients for use in a broad range of applications, such as in high-throughput investigations of surface properties, as means to guide the motions and/or assembly of liquid droplets, vesicles, nanoparticles, and cells and as new media for stationary-phase-gradient chemical separations. Our groups have been working to develop new methods for preparing chemical gradients from organoalkoxysilane and organochlorosilane precursors and to obtain a better understanding of their properties on macroscopic to microscopic length scales. This review highlights our recent work on the development of controlled-rate infusion and infusion-withdrawal dip-coating methods for the preparation of gradients on planar glass and silicon substrates, on thin-layer chromatography plates, and in capillaries and monoliths for liquid chromatography. We also cover the new knowledge gained from the characterization of our gradients using sessile drop and Wilhelmy plate dynamic water contact angle measurements, X-ray photoelectron spectroscopy mapping, and single-molecule tracking and spectroscopy. Our studies reveal important evidence of phase separation and cooperative interactions occurring along multicomponent gradients. Emerging concepts and new directions in the preparation and characterization of organosilane-based chemical gradients are also discussed.

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Combinatorial Methods for Polymer Science

Cited by 6 publications

References 54 publications

Combinatorial and High-Throughput Screening of Materials Libraries: Review of State of the Art

Combinatorial and High-Throughput Screening of Materials Libraries: Review of State of the Art

A multilens measurement platform for high-throughput adhesion measurements

Organosilane Chemical Gradients: Progress, Properties, and Promise

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