Combinatorial synthesis of soluble conjugated polymeric nanoparticles and tunable multicolour fluorescence sensing

Zhao, Peng; Dai, Yanan; Wu, Yusen; Wang, Lili; Huang, Binlei; Ding, Yun; Hu, Aiguo

doi:10.1039/c7py01233k

Cited by 20 publications

(25 citation statements)

References 42 publications

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“…It is evident that electron-rich organic analytes (alkylamine and arenes) cluster together, while analytes with electron deficient substituents (nitroaromatics, aromatic aldehydes, and aliphatic acids) form separate groups. Alkyl alcohols, causing little fluorescence change, cluster together with control group, and inorganic strong acids, which tend to a Note that "SCPN (xyz) " means the SCPN is prepared from the polycondensation between monomer A (x) and B (y) in confined nanoreactors 44 and post-modified with terminal group T (z) (which is not afforded for sensors in A−D columns). robustly quench the fluorescence of SCPN sensors form another cluster.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…42,43 A large number of SCPNs were facilely prepared with combinatorial chemistry method, and tunable fluorescence emissions were achieved by simply varying the monomers and terminals. 44 Herein, we report an array consisting of 36 sets of SCPNs and the vector of every analyte in the full 108dimensional space was used for the identification of volatile compounds, including nitroaromatics, aromatic aldehydes, arenes, alkyl alcohols, amines, and acids (30 kinds of analytes). PCA and HCA indicated that the diversities of electronic structures, miscibility and saturated vapor pressure of analytes were keys in differentiating these analytes.…”

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confidence: 99%

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Conjugated Polymer Nanoparticles Based Fluorescent Electronic Nose for the Identification of Volatile Compounds

Zhao

Feng

et al. 2018

Anal. Chem.

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A fluorescence sensing array (or fluorescent electronic nose) is designed on a disposable paper card using 36 sets of soluble conjugated polymeric nanoparticles (SCPNs) as sensors to easily identify wide ranges of volatile analytes, including explosives and toxic industrial chemicals (amines and pungent acids). A 108-dimensional vector obtained from the fluorescent color change in the sensing array is defined and directly treated as an index in a standard chemical library (30 kinds of volatile analytes and a control group). Hierarchical clustering analysis (HCA) and principal component analysis (PCA) indicated the diversity in electronic structures; saturated vapor pressure and miscibility of analytes are keys in differentiating the analytes, with electron-rich arenes and alkylamines enhancing fluorescence and electron-deficient analytes attenuating fluorescence. A support vector machine (SVM) works well to predict an unknown sample, reaching 99.5% accuracy. The excellent fluorescence stability (no fluorescence quenching after being exposed in air for one month) and high sensitivity (emission color changes within minutes when exposed to analytes) suggest that the fluorescent polymer-based electronic nose will play an important role in field detection and identification of a wide spreading of hazardous substances.

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Section: ■ Results and Discussionmentioning

confidence: 99%

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confidence: 99%

Conjugated Polymer Nanoparticles Based Fluorescent Electronic Nose for the Identification of Volatile Compounds

Zhao

Feng

et al. 2018

Anal. Chem.

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“…Conjugated microporous polymers (CMPs) have found increasing interest as potential materials for gas storage and separation . The combined chemical and thermal stability of conjugated polymers (CPs) allow to potentially consider these organic materials to be complementary to their inorganic counterparts such as zeolites, ceramic, and carbon molecular sieves .…”

Section: Introductionmentioning

confidence: 99%

“…The combined chemical and thermal stability of conjugated polymers (CPs) allow to potentially consider these organic materials to be complementary to their inorganic counterparts such as zeolites, ceramic, and carbon molecular sieves . To obtain a microporous structure, CPs are either crosslinked to form a network of covalently interconnected chains, or a (hyper)branched structure is formed to disrupt the π‐stacking of polymer backbones . The former procedure “crosslinking” however often results in insoluble polymer network difficult to process in membranes, and therefore the branching technique is more appealing .…”

Section: Introductionmentioning

confidence: 99%

“…To obtain a microporous structure, CPs are either crosslinked to form a network of covalently interconnected chains, or a (hyper)branched structure is formed to disrupt the π‐stacking of polymer backbones . The former procedure “crosslinking” however often results in insoluble polymer network difficult to process in membranes, and therefore the branching technique is more appealing . Among the investigated branched CPs, polythiophene (PT), the benchmark CP and the most investigated in electro‐optical applications, has scarcely been reported .…”

Section: Introductionmentioning

confidence: 99%

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Influence of Branching of Polythiophenes on the Microporosity

Mulunda

Zhang

Nies

et al. 2018

Macro Chemistry & Physics

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A chain growth polymerization of a branched polythiophene (BT) using a Pd(Ruphos) catalyst, as a promising route to synthesize microporous conjugated polymers with well‐defined structures is reported. From N2 adsorptions/desorption isotherm measurements, a Brunauer–Emmett–Teller surface area of 40.7 m2 g−1 is calculated for the BT, significantly higher than that of the linear poly(3‐hexylthiophene) (P3HT) (25.7 m2 g−1). The same trend is confirmed by simulations of the two polymer structures, from which a geometric surface area (SAgeo) of 140 ± 15.8 m2 g−1 is calculated for the BT, much more higher than for the P3HT with a SAgeo of 6.7 ± 7.1 m2 g−1. Moreover, the BT is soluble in common organic solvent and is readily processed in membrane with a CO2/N2 selectivity up to 24.

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Non‐Equilibrium Dissipative Assembly with Switchable Biological Functions

Zhao,

et al. 2024

Angewandte Chemie

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Natural dissipative assembly (DSA) often exhibit energy‐driven shifts in natural functions. However, creating man‐made DSA that can mimic such biological activities transformation remains relatively rare. Herein, we introduce a cytomembrane‐like dissipative assembly system based on chiral supramolecules. This system employs benzoyl cysteine in an out of equilibrium manner, enabling the shifts in biofunctions while minimizing material use. Specifically, aroyl‐cystine derivatives primarily assemble into stable M‐helix nanofibers under equilibrium conditions. These nanofibers enhance fibroblast adhesion and proliferation through stereospecific interactions with chiral cellular membranes. Upon the addition of chemical fuels, these functional nanofibers temporarily transform into non‐equilibrium nanospheres, facilitating efficient drug delivery. Subsequently, these nanospheres revert to their original nanofiber state, effectively recycling the drug. The programmable function‐shifting ability of this DSA establishes it as a novel, fuel‐driven drug delivery vehicle. And the bioactive DSA not only addresses a gap in synthetic DSAs within biological applications but also sets the stage for innovative designs of 'living' materials.

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Combinatorial synthesis of soluble conjugated polymeric nanoparticles and tunable multicolour fluorescence sensing

Abstract: Combinatorial polymerization method has been exploited to prepare a library of soluble conjugated polymeric nanoparticles (SCPNs), by varying symmetrical monomers, Ax and By (x > 2, y ≥ 2), plus modification with variant terminal groups.

Cited by 20 publications

References 42 publications

Conjugated Polymer Nanoparticles Based Fluorescent Electronic Nose for the Identification of Volatile Compounds

Conjugated Polymer Nanoparticles Based Fluorescent Electronic Nose for the Identification of Volatile Compounds

Influence of Branching of Polythiophenes on the Microporosity

Non‐Equilibrium Dissipative Assembly with Switchable Biological Functions

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