Combinatorial therapeutic approach for treatment of oral squamous cell carcinoma

Abstract

Oral squamous cell carcinoma (OSCC) is one of the common type of cancer in humans. A combinatorial approach has been done by using paclitaxel (PTX), 5-fluorouracil (5-FU) and ascorbic acid (AA) loaded solid lipid nanoparticles (SLN) for its treatment. SLN were made by high-speed homogenization and ultrasonication technique and they were used alone and in combination to check their efficacy against OSCC induced animal model. Pharmacokinetics and biodistribution study of the optimized formulations for PTX, 5-FU and AA loaded SLN was performed. The SLN shows a biphasic nature of drug release both in the in-vitro and in-vivo system. SLN loaded with PTX in combination with SLN loaded with AA shows a greater potency in the treatment of OSCC in-vivo. The Pharmacokinetic and biodistribution studies of SLN depict a better therapeutic efficacy. The combination of PTX and AA loaded SLN can be a novel approach for the treatment of OSCC.

Nanoparticles in Dentistry: A Comprehensive Review

“…Doxorubicin (DOX) and paclitaxel are two of the most commonly used chemotherapeutic drugs [ 239 ]. Taking their adverse effects into consideration, studies have proposed alternative forms of drug delivery, such as liposome formulations [ 239 ], solid lipid NPs [ 240 ], mucoadhesive alginate pastes with embedded liposomes [ 241 ], methotrexate-loaded stimuli responsive silica-based NPs [ 242 ], polymers [ 243 ], PEGylated NPs [ 244 , 245 ], mesoporous silica NPs-polymerpolyethylenimine [ 246 ], multifunctional targeted polymeric NPs [ 247 ], and a multifunctional Au nanoplatform [ 248 ]. In comparison to the free drugs, these new systems showed a higher percentage of apoptotic cells [ 239 , 247 ], fewer hematological changes [ 242 ], significant therapeutic efficacy [ 243 , 248 ], significant inhibitory effects on tumor growth [ 245 ], lower cytotoxicity and systemic toxicity, and higher tumor accumulation of DOX [ 244 ].…”

Oral Squamous Cell Carcinoma and the Cutting Edge of Nanotechnology

“…High drug payload, sustained release nature, and biocompatibility are some of their advantages [72]. SLN and NLC also act as a potential delivery tool for anticancer drugs against OSCC [73,74]. Recently, inorganic nanoparticles attracted attention due to their distinct physicochemical properties that are better than those of polymeric and lipid nanoparticles.…”

Cetuximab-Conjugated Perfluorohexane/Gold Nanoparticles for Low Intensity Focused Ultrasound Diagnosis Ablation of Thyroid Cancer Treatment

“…In addition, studies in histology andimmunohistochemistry were conducted. Sections of the tissue werestained with histophalogy [48][49][50].…”