Combinatorial therapeutic drug delivery of riboflavin and dexamethasone for the treatment of keratoconus affected corneas of mice: Ex vivo permeation and hemolytic toxicity

Wo, Na; Zhai, Jia-bin

doi:10.1049/mna2.12079

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…Another thermo-responsive gel for the co-delivery of dexamethasone and riboflavin has been developed from poloxamer 407 and hydroxypropyl methylcellulose. The gel displayed a therapeutic role in the increasing thickness of keratoconus and corneal fibroblast cells [ 169 ].…”

Section: Nano-based Dds For Anterior Segment Diseasesmentioning

confidence: 99%

Breaking Barriers in Eye Treatment: Polymeric Nano-Based Drug-Delivery System for Anterior Segment Diseases and Glaucoma

Ashkar

Jain

et al. 2023

Polymers

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The eye has anatomical structures that function as robust static and dynamic barriers, limiting the penetration, residence time, and bioavailability of medications administered topically. The development of polymeric nano-based drug-delivery systems (DDS) could be the solution to these challenges: it can pass through ocular barriers, offering higher bioavailability of administered drugs to targeted tissues that are otherwise inaccessible; it can stay in ocular tissues for longer periods of time, requiring fewer drug administrations; and it can be made up of polymers that are biodegradable and nano-sized, minimizing the undesirable effects of the administered molecules. Therefore, therapeutic innovations in polymeric nano-based DDS have been widely explored for ophthalmic drug-delivery applications. In this review, we will give a comprehensive overview of polymeric nano-based drug-delivery systems (DDS) used in the treatment of ocular diseases. We will then examine the current therapeutic challenges of various ocular diseases and analyze how different types of biopolymers can potentially enhance our therapeutic options. A literature review of the preclinical and clinical studies published between 2017 and 2022 was conducted. Thanks to the advances in polymer science, the ocular DDS has rapidly evolved, showing great promise to help clinicians better manage patients.

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Section: Nano-based Dds For Anterior Segment Diseasesmentioning

confidence: 99%

Breaking Barriers in Eye Treatment: Polymeric Nano-Based Drug-Delivery System for Anterior Segment Diseases and Glaucoma

Ashkar

Jain

et al. 2023

Polymers

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“…The hemolytic technique is used to determine isotonicity. The produced formulations were administered to a few blood drops, which were then compared to hypotonic, hypertonic, and normal saline solutions under a 45× optical microscope (Wo and Zhai, 2021).…”

Section: Ph and Isotonicity Of Prepared Formulationsmentioning

confidence: 99%

Novel in-situ emulgel of acetazolamide for ocular drug delivery

Ali¹,

Habibullah²,

Mohanty³

et al. 2022

J App Pharm Sc

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In this investigation, a novel in-situ emulgel of acetazolamide was developed and evaluated. The gel was prepared using corn oil, pectin, and GellanGum at different concentrations of 10%-50% (w/w) and added to the homogenizer tube followed by the addition of the emulsifier (Tween 80 and span 80 in the ratio of 1:1) at 0.2% (w/w). The pH of all five formulations was between 5.58 and 5.75. The Fourier-transform infrared spectroscopy (FTIR) spectrum of all the formulations showed broadband in between the wavenumber range of 3,700 cm −1 and 2,980 cm −1 . The FTIR spectrum of all the formulations showed broadband in between the wavenumber range of 3,700 cm −1 and 2,980 cm −1 . The drug content in the samples was determined by a spectrophotometer at 267 nm The drug release mechanism may be Fickian transport (0.45 ≤ n), anomalous (non-Fickian) transport (0.45 ≤ n < 0.89), and/or super case-II transport (n > 0.89).The n values of all formulations were greater than 0.45. The in-vivo corneal tolerance experimentation of the prepared formulation eyes was assessed for 72 hours and found to be biocompatible based on visual inspection.

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The effect of dexamethasone addition to gentamicin polymeric films of hydroxypropyl methylcellulose/chitosan and hydroxypropyl methylcellulose/polyvinylpyrrolidone

Jaber,

Saadh,

Obeid

2024

Polymer Engineering & Sci

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Many polymeric film formulas containing antibiotics failed in preventing microbial infections due to microbial resistance. One of the main reasons for microbial resistance is the formation of biofilm layers which prevent the drug from reaching the active site. This study aims to evaluate the effect of dexamethasone addition to polymeric film formula containing gentamicin. The polymeric formula containing both dexamethasone and gentamicin were characterized in terms of film's diameters, content uniformity, moisture content, matrix‐drugs association, and drug release. Antibiofilm and antimicrobial activity were used to evaluate polymeric formula containing drug. The addition of dexamethasone to the polymeric formula revealed that most of dexamethasone released and diffused in the first 300 min, while gentamicin release and diffusion had a slower rate like the release of gentamicin from formulations without dexamethasone. The addition of dexamethasone resulted in improved antibiofilm and antibacterial activity with the lowest antibiofilm activity >96% and antibacterial activity >87%. Therefore, dexamethasone addition to polymeric formula containing gentamicin improved the biological activity without any effects on the film characteristics.Highlights Dexamethasone addition to polymeric formula containing gentamicin significantly improved the biological activity. Most of dexamethasone released and diffused in the first 300 min. The addition of dexamethasone resulted in the lowest antibiofilm activity of gentamicin of >96% and antibacterial activity >87%.

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Combinatorial therapeutic drug delivery of riboflavin and dexamethasone for the treatment of keratoconus affected corneas of mice: Ex vivo permeation and hemolytic toxicity

Cited by 5 publications

References 23 publications

Breaking Barriers in Eye Treatment: Polymeric Nano-Based Drug-Delivery System for Anterior Segment Diseases and Glaucoma

Breaking Barriers in Eye Treatment: Polymeric Nano-Based Drug-Delivery System for Anterior Segment Diseases and Glaucoma

Novel in-situ emulgel of acetazolamide for ocular drug delivery

The effect of dexamethasone addition to gentamicin polymeric films of hydroxypropyl methylcellulose/chitosan and hydroxypropyl methylcellulose/polyvinylpyrrolidone

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