Combinatorial therapeutic effect of resveratrol and piperine on murine model of systemic lupus erythematosus

Pannu, Naveet

doi:10.1007/s10787-019-00662-w

Cited by 24 publications

(18 citation statements)

References 26 publications

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“…It has also been employed to increase the pharmacokinetics (i.e., bioavailability and/or bioactivity) of certain other nutraceutical agents such as curcumin, quercetin, barbiturates, beta‐carotene, resveratrol, coenzyme Q10, vitamin B‐6, selenium, phyllanthin, propranolol, and theophylline (Derosa, Maffioli, & Sahebkar, 2016). In this context, several reports revealed the bio‐enhancement effect of piperine on curcumin, metformin, and resveratrol (Arcaro et al, 2014; Atal et al, 2016; Chakraborty et al, 2017; Miyazawa et al, 2018; Pannu & Bhatnagar, 2019; Shoba et al, 1998). Furthermore, zein‐carrageenan core‐shell nanoparticles may effectively deliver and enhance the biological function of piperine and curcumin in co‐delivery systems (Chen et al, 2020).…”

Section: Combinational Therapy Using Piperinementioning

confidence: 99%

“…Recently, Cui and coworkers demonstrated that piperine inactivates cytochrome P450 (CYP) 3A (CYP3A), which plays a critical role in drug metabolism (Cui et al, 2020). It, in addition, enhances the anti‐inflammatory effects when combined with resveratrol (Pannu & Bhatnagar, 2019). Piperine also modulates the membrane dynamics and increases the absorption site permeability.…”

Section: Absorption and Metabolismmentioning

confidence: 99%

“…aureus ‐induced diseases (Zhai et al, 2016). Findings by Pannu and Bhatnagar (2019) highlighted the combinational effects of piperine with resveratrol in controlling inflammatory responses caused by systemic lupus erythematosus in the murine model. In addition, piperine controls the inflammatory factors and oxidative damage in cardiomyocytes (Yan et al, 2019).…”

Section: Health Perspectivesmentioning

confidence: 99%

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Piperine: A review of its biological effects

Haq

Imran

Nadeem

et al. 2020

Phytotherapy Research

235

106

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Medicinal plants have been used for years as a source of food, spices, and, in traditional medicine, as a remedy to numerous diseases. Piper nigrum, belonging to the family Piperaceae is one of the most widely used spices all over the world. It has a distinct sharp flavor attributed to the presence of the phytochemical, piperine. Apart from its use as a spice, P. nigrum is frequently used for medicinal, preservation, and perfumery purposes. Black pepper contains 2–7.4% of piperine, varying in content is associated with the pepper plant. Piperine displays numerous pharmacological effects such as antiproliferative, antitumor, antiangiogenesis, antioxidant, antidiabetic, anti‐obesity, cardioprotective, antimicrobial, antiaging, and immunomodulatory effects in various in vitro and in vivo experimental trials. Furthermore, piperine has also been documented for its hepatoprotective, anti‐allergic, anti‐inflammatory, and neuroprotective properties. This review highlights and discusses the medicinal and health‐promoting effects of piperine, along with possible mechanisms of its action in health promotion and disease prevention. In addition, the present review summarizes the recent literature related to piperine as a therapeutic agent against several diseases.

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Section: Combinational Therapy Using Piperinementioning

confidence: 99%

Section: Absorption and Metabolismmentioning

confidence: 99%

Section: Health Perspectivesmentioning

confidence: 99%

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Piperine: A review of its biological effects

Haq

Imran

Nadeem

et al. 2020

Phytotherapy Research

235

106

View full text Add to dashboard Cite

show abstract

“… Antidiabetic Antioxidant [ 43 ] Systemic lupus erythematosus (SLE) BALB/c inbred strain of mice (N=100; pristane-induced SLE murine model) Intraperitoneal injection/ RSV (25 mg/kg; 50 mg/kg) and bio-enhancer piperine (2.5 mg/kg; 5 mg/kg) The combination of RSV and piperine significantly reduced the expression of related factors of SEL, but did not affect the level of antibodies. Antioxidant Anti-inflammatory [ 44 ] Inflammatory bowel diseases (IBD) C57BL/6 WT and Nrf2 −/− mice (induced by dextran sulfate sodium); Human colon cancer LS174T and Caco2 cells Intraperitoneal injection/ Imine RSV Analog 2-Methoxyl-3,6-Dihydroxyl-IRA (C33); RSV (200 mg/kg) The derivative C33 modified by RSV showed stronger anti-inflammatory effect, and effectively improved IBD by activating Nrf2 signaling pathway in-vivo and in-vitro . Anti-inflammatory [ 45 ] Autoimmune encephalomyelitis (AE) C57BL/6 mice Intraperitoneal injection/ RSV (10 mg/kg; 25 mg/kg; 50 mg/kg) RSV reduced oxidative stress and inflammation in EAE mice to protect the integrity of blood-brain barrier.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Can Attenuate Astrocyte Activation to Treat Spinal Cord Injury by Inhibiting Inflammatory Responses

et al. 2021

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Several preclinical and clinical studies have attempted to elucidate the pathophysiological mechanism associated with spinal cord injury. However, investigations have been unable to define the precise related mechanisms, and this has led to the lack of effective therapeutic agents for the condition. Neuroinflammation is one of the predominant processes that hinder spinal cord injury recovery. Resveratrol is a compound that has several biological features, such as antioxidation, antibacterial, and antiinflammation. Herein, we reviewed preclinical and clinical studies to delineate the role of toll-like receptors, nod-like receptors, and astrocytes in neuroinflammation. In particular, the alteration of astrocytes in SCI causes glial scar formation that impedes spinal cord injury recovery. Therefore, to improve injury recovery would be to prevent the occurrence of this process. Resveratrol is safe and effective in the significant modulation of neuroinflammatory factors, particularly those mediated by astrocytes. Thus, its potential ability to enhance the injury recovery process and ameliorate spinal cord injury.

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“…Although RSV was unable to abrogate autoantibody formation (86), the traditional Chinese prescription Lang Chuang Fang (LCF), which can also increase the expression of SIIRT1, was shown to downgrade dsDNA autoantibody and improve lupus nephritis (87). Another Chinese herbal medicine named Honokiol (HNK) was capable of alleviating manifestation of the severe form of lupus nephritis (AFLN) by negative regulation of T cell functions and by enhancement of SIRT1/autophagy axis activation (101,102).…”

Section: The Potential Roles and Therapeutic Prospects Of Sirt1 In Sle Sirt1 In Immune Cells And Slementioning

confidence: 99%

The Role of Sirtuin-1 in Immune Response and Systemic Lupus Erythematosus

et al. 2021

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Systemic lupus erythematosus (SLE) is a potentially fatal multisystem inflammatory chronic disorder, the etiology and pathogenesis of which remain unclear. The loss of immune tolerance in SLE patients contributes to the production of autoantibodies that attack multiple organs and tissues, such as the skin, joints, and kidneys. Immune cells play important roles in the occurrence and progression of SLE through amplified immune responses. Sirtuin-1 (SIRT1), an NAD+-dependent histone deacetylase, has been shown to be a pivotal regulator in various physiological processes, including cell differentiation, apoptosis, metabolism, aging, and immune responses, via modulation of different signaling pathways, such as the nuclear factor κ-light-chain-enhancer of activated B cells and activator protein 1 pathways. Recent studies have provided evidence that SIRT1 could be a regulatory element in the immune system, whose altered functions are likely relevant to SLE development. This review aims to illustrate the functions of SIRT1 in different types of immune cells and the potential roles of SIRT1 in the SLE pathogenesis and its therapeutic perspectives.

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Combinatorial therapeutic effect of resveratrol and piperine on murine model of systemic lupus erythematosus

Cited by 24 publications

References 26 publications

Piperine: A review of its biological effects

Piperine: A review of its biological effects

Resveratrol Can Attenuate Astrocyte Activation to Treat Spinal Cord Injury by Inhibiting Inflammatory Responses

The Role of Sirtuin-1 in Immune Response and Systemic Lupus Erythematosus

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