Combined 0.1% Retinaldehyde/ 6% Glycolic Acid Cream in Prophylaxis and Treatment of Acne Scarring

Dréno, Brigitte; Katsambas, Andreas; Pelfini, C.; Plantier, Daniel Toscan du; E, Jancovici; Ribet, Virginie; Nocera, Thérèse; Morinet, P.; Khammari, Amir

doi:10.1159/000099593

Cited by 16 publications

(11 citation statements)

References 44 publications

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“…Its good tolerability was confirmed in a larger patient population and demonstrated in association with other topical acne treatments (except retinoids) [67] (EBM‐level 4, n = 1709). The preparation was also effective in the prevention and treatment of acne scarring [68] (EBM‐level 2b, n = 145). A combination study of topical retinaldehyde 0.1 % gel with erythromycin 4 % lotion compared to the erythromycin monotherapy patients reported good tolerability.…”

Section: Retinaldehydementioning

confidence: 99%

Topical retinoids in acne – an evidence‐based overview

Thielitz

Abdel-Naser

Fluhr

et al. 2008

J Deutsche Derma Gesell

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SummaryTopical retinoids are important tools in the management of acne because they act against comedones and microcomedones and have direct anti-inflammatory effects. The substances approved for acne treatment comprise tretinoin (all-trans-retinoic acid), isotretinoin (13-cis retinoic acid) as well as the synthetic third-generation polyaromatic retinoids adapalene and tazarotene, the latter being approved for acne treatment in the US only. Retinaldehyde is used in cosmetic preparations against acne. All topical retinoids are effective as single agents in mild to moderate acne but differ in efficacy and tolerability. Tazarotene 0.1 % is more effective than tretinoin 0.025 % or 0.1 % microsphere gel or adapalene 0.1 % gel or cream (EBM-level 2c). Adapalene 0.1 % is equally effective to tretinoin 0.025 % or tretinoin microsphere 0.1 % gel or tretinoin 0.05 % cream or isotretinoin 0.05 % gel (EBM-level 2c). Adapalene 0.1 % gel is significantly better tolerated than tazarotene 0.1 % gel, tretinoin 0.025 % and tretinoin 0.05 % gel, tretinoin 0.05 % cream, tretinoin microsphere 0.1 % gel or isotretinoin 0.05 % gel (EBMlevel 2c). The safety profile of topical retinoids differs from their systemic counterparts and is related mainly to local adverse effects, such as erythema, dryness, itching and stinging. The currently available evidence justifies the use of topical retinoids in most types of acne and during maintenance treatment.

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Section: Retinaldehydementioning

confidence: 99%

Topical retinoids in acne – an evidence‐based overview

Thielitz

Abdel-Naser

Fluhr

et al. 2008

J Deutsche Derma Gesell

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“…Moreover, 0.1 % retinaldehyde in association with 6 % glycolic acid (GA) has shown a signi fi cant decreasing in both in fl ammatory and retentional lesions in acne patients [ 10 ] . Also, this combination seems to be effective to prevent and treat acne scars [ 11 ] .…”

Section: Nonprescription Retinoids and Vitamin A Derivatesmentioning

confidence: 99%

Cosmeceuticals in Dermatology

Tedeschi

West

Guzzardi

et al. 2013

Update in Cosmetic Dermatology

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“…Moreover, retinoids are known to activate fibroblasts, to increase type I procollagen and to decrease matrix metalloproteinase (MMP) expression in skin damaged by ultraviolet (UV) irradiation [1,7], to improve the skin texture and to reduce skin discoloration [8]. Retinal (retinaldehyde; RAL), a natural precursor of retinoic acid, has been shown to exert the biological activities of retinoids and to be likewise beneficial for the treatment of photoaging [9] and acne scarring [10]. Although application of retinal is useful in clinical dermatology and cosmetology, there are still some limitations concerning the topical application such as its photochemical instability and irritation in long-term application.…”

Section: Introductionmentioning

confidence: 99%

Microneedle-Facilitated Intradermal Proretinal Nanoparticle Delivery

et al. 2020

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Topical retinoid treatments stimulate biological activities in the skin. The main physical barrier, which limits the efficacy of transdermal drug delivery, is the stratum corneum. Proretinal nanoparticles (PRN) have already been proven to efficiently deliver retinal into the epidermis. In the present study, two transdermal drug delivery systems, microneedles (MN) and PRN, were combined to directly target the dermis. The microchannels induced by the MN, the PRN localization in the microchannels and the skin closure kinetics were investigated by non-invasive imaging techniques, such as dermoscopy, optical coherence tomography and multiphoton tomography. Additionally, the amount of retinal in the epidermis and dermis after application in three different forms (PRN-Loaded microneedles, PRN suspension or conventional retinal solution) was compared. All imaging techniques confirmed the formation of microchannels in the skin, which were partly still detectable after 24 h. Multiphoton tomography showed the release of PRN from the MN within the microchannels. The recovered retinal concentration in the dermis was significantly higher when applied via PRN-loaded microneedles. We hypothesized that this platform of PRN-loaded microneedles can provide a rapid and efficient administration of retinal in the dermis and could be of benefit in some skin conditions such as atrophic scar or photo-aged skin.

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Combined 0.1% Retinaldehyde/ 6% Glycolic Acid Cream in Prophylaxis and Treatment of Acne Scarring

Cited by 16 publications

References 44 publications

Topical retinoids in acne – an evidence‐based overview

Topical retinoids in acne – an evidence‐based overview

Cosmeceuticals in Dermatology

Microneedle-Facilitated Intradermal Proretinal Nanoparticle Delivery

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