Combined 18F-fluorodeoxyglucose-positron emission tomography and computed tomography as a primary screening method for detecting second primary cancers and distant metastases in patients with head and neck cancer

Kim, S. Y.; Roh, Jong–Lyel; Yeo, Nam-Kyung; Kim, J. S.; Lee, J. H.; Choi, Seung‐Ho; Nam, Soon Yuhl

doi:10.1093/annonc/mdm270

Cited by 109 publications

(90 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A robust Warburg effect in human metastatic lesions, detected with combined 18 F-fluorodeoxyglucosepositron emission tomography imaging, indicates that metastatic cells have impaired energy metabolism like that of most cancer cells [18,20,246]. Hence, invasion and metastasis can be linked to impaired energy metabolism if this impairment occurs in cells of hematopoietic or myeloid origin.…”

Section: Invasion and Metastasismentioning

confidence: 99%

Cancer as a Metabolic Disease

Seyfried¹

2012

194

291

View full text Add to dashboard Cite

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention.

show abstract

Section: Invasion and Metastasismentioning

confidence: 99%

Cancer as a Metabolic Disease

Seyfried¹

2012

194

291

View full text Add to dashboard Cite

show abstract

“…In head and neck oncology, the main clinical situations comprise the initial staging and investigation of lymph node metastatic disease (7,8) and hematogenic disease, detection of primary lesions in cases of occult primary tumors (9) , evaluation of response to radiotherapy and/or chemotherapy, and investigation of early recurrence of disease and second primary tumor. In all such conditions changes in the approach may potentially occur (10) .…”

Section: Introductionmentioning

confidence: 99%

Valor da PET/CT na abordagem do câncer de cabeça e pescoço

Curioni

Souza²,

Amar

et al. 2012

Radiol Bras

View full text Add to dashboard Cite

Objective: To evaluate the role of PET/CT in the approach to patients with head and neck cancer. Materials and Methods: Retrospective study of medical records and PET/CT images of 63 patients with head and neck cancer. Results: Alterations were observed in 76% of the cases. Out of these cases, 7 (11%) were considered as false-positive, with SUV < 5.0. PET/CT demonstrated negative results in 15 cases (24%). Among the 14 cases where the method was utilized for staging, 3 (22%) had their stages changed. Conclusion: PET/CT has shown to be of potential value in the routine evaluation of patients with head and neck cancer, but further studies of a higher number of cases are required to define a protocol for utilization of the method. Keywords: Emission computed tomography; Fluorodeoxyglucose 18F; Head and neck neoplasms; Neoplasm staging; Squamous cell carcinoma.Objetivo: Avaliar a PET/CT na abordagem de pacientes com câncer de cabeça e pescoço. Materiais e Métodos: Estudo retrospectivo de 63 prontuários e exames de PET/CT de pacientes com câncer de cabeça e pescoço. Resultados: Foram encontradas alterações em 76% dos exames. Destes, 7 (11%) foram considerados falso-positivos, com SUV < 5,0. A PET/CT mostrou-se negativa em 15 situações (24%). Dos 14 casos nos quais se utilizou o exame para estadiamento, em 3 (22%) houve aumento no estadiamento. Conclusão: A PET/CT mostra-se como exame de potencial valor na rotina de avaliação de pacientes com câncer de cabeça e pescoço, entretanto, necessitamos de maior número de casos para definirmos protocolo de uso. Unitermos: Tomografia computadorizada de emissão; Fluordesoxiglicose F18; Neoplasias de cabeça e pescoço; Estadiamento de neoplasias; Carcinoma de células escamosas. AbstractResumo * Study developed in the

show abstract

“…1 In 39 of these 40 patients FDGPET-CT correctly picked up second cancers or distant metastasis. There was one false negative and 23 false positive result.…”

Section: 2mentioning

confidence: 98%

“…After imaging, the staging of the tumour or node is upgraded in at least 30% of cases. 1 The incidence of distant metastasis in advanced head and neck malignances is influenced by various factors like location and size of primary tumour (T), lymph node stage and local control of disease above the clavicle. Lung metastases are most common in squamous cell carcinoma accounting for around 66% other being bone.…”

Section: Introductionmentioning

confidence: 99%

Compare the role of positron emission tomography scan to conventional imaging in the evaluation of advanced head and neck cancers

Dutta

Chaitra

Singh

2017

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

INTRODUCTIONHead and neck cancer is the most common cancer in India. The most common site involved is oral cavity. The other common sites are larynx, hypopharynx and nasopharynx. Radiology in form of CT/MRI is the mainstay of assessing and staging advanced head and neck malignancy. Magnetic resonance imaging is the preferred tool for investigating the primary tumour in all head and neck sites, particularly for assessing cartilage, bone, perineural, and perivascular invasion. Imaging is crucial to know the site, extent and infiltration to the adjacent structures of a histologically proven primary tumour and to detect the presence of enlarged lymph nodes. After imaging, the staging of the tumour or node is upgraded in at least 30% of cases. 1The incidence of distant metastasis in advanced head and neck malignances is influenced by various factors like location and size of primary tumour (T), lymph node stage and local control of disease above the clavicle. Lung metastases are most common in squamous cell carcinoma accounting for around 66% other being bone. Hence it is imperative to diagnose distant metastasis at initial presentation.2 Whole body PET-CT helps in the detection of distant metastasis especially in high risk and advanced head and neck squamous cell carcinoma.The aim of the study to the compare the role of PETCT scans to MRI in the initial evaluation in advanced cancers of head and neck. ABSTRACTBackground: Advanced stages of head and neck cancers need careful evaluation by imaging to rule out multiple nodal and distant metastasis which might influence management and prognosis. The aim of the study was to compare the role of PETCT scan to MRI in the initial evaluation in advanced cancers of head and neck. Methods: The study included 46 patients having advanced stages of head and neck squamous cancers. The patients underwent clinical examination, endoscopy, an initial CT/MRI of the disease site and conventional metastatic workup with an X-ray Chest and USG abdomen. The patients then underwent PET/CT. Tumor restaging was done after the PETCT and the results of CT/ MRI to PETCT were compared. Results: There was upstaging of disease in patients with identification of multiple/ bilateral nodes and distant metastasis following PETCT. Conclusions: PETCT scan has an impact on the initial upstaging staging of disease compared to conventional imaging.

show abstract

Combined 18F-fluorodeoxyglucose-positron emission tomography and computed tomography as a primary screening method for detecting second primary cancers and distant metastases in patients with head and neck cancer

Cited by 109 publications

References 17 publications

Cancer as a Metabolic Disease

Cancer as a Metabolic Disease

Valor da PET/CT na abordagem do câncer de cabeça e pescoço

Compare the role of positron emission tomography scan to conventional imaging in the evaluation of advanced head and neck cancers

Contact Info

Product

Resources

About