Combined aerobic exercise and high-intensity respiratory muscle training in patients surgically treated for non-small cell lung cancer: a pilot randomized clinical trial

Messaggi-Sartor, Monique; Marco, Ester; Martínez-Téllez, Elisabeth; Rodríguez-Fuster, Alberto; Palomares, Carolina; Chiarella, Sandra; Muniesa, Josep M.; Orozco-Levi, Mauricio; Barreiro, Esther; Güell, María Rosa

doi:10.23736/s1973-9087.18.05156-0

Cited by 68 publications

(135 citation statements)

References 29 publications

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“…Similarly, a recent study including patients with surgically resected NSCLC (stage I–II) detected a significant VO 2peak increment in the EX group versus control . Globally considered, although some studies did not report any significant change in functional capacity following a training period , the majority agreed on the potential beneficial effect of exercise on cardiorespiratory fitness .…”

Section: Investigated Outcomes In Lung Cancermentioning

confidence: 98%

“…Focusing on studies including only patients with lung cancer, no clear advantage in terms of QoL after applying a physical exercise program is evident . A randomized controlled trial attempted to assess the impact of EX intervention on QoL in 81 patients undergoing thoracotomy.…”

Section: Investigated Outcomes In Lung Cancermentioning

confidence: 99%

“…However, in the first year after surgery, patients usually experience an increase in pulmonary parameters that may be attributed to compensatory mechanisms, such as the expansion of the remaining lobes and vascular tissues . In this postoperative context, studies testing different training programs are consistent in detecting an improvement in respiratory muscle strength and/or functionality . A retrospective study evaluated the outcome of a comprehensive rehabilitation schedule on pulmonary function in 82 patients with lung cancer (stage IIB–IV).…”

Section: Investigated Outcomes In Lung Cancermentioning

confidence: 99%

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Physical Activity and Exercise in Lung Cancer Care: Will Promises Be Fulfilled?

Avancini

Sartori

Gkountakos³

et al. 2019

The Oncologist

124

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Lung cancer remains the leading cause of cancer‐related death worldwide. Affected patients frequently experience debilitating disease‐related symptoms, including dyspnea, cough, fatigue, anxiety, depression, insomnia, and pain, despite the progresses achieved in term of treatment efficacy. Physical activity and exercise are nonpharmacological interventions that have been shown to improve fatigue, quality of life, cardiorespiratory fitness, pulmonary function, muscle mass and strength, and psychological status in patients with lung cancer. Moreover, physical fitness levels, especially cardiorespiratory endurance and muscular strength, are demonstrated to be independent predictors of survival. Nevertheless, patients with lung cancer frequently present insufficient levels of physical activity and exercise, and these may contribute to quality of life impairment, reduction in functional capacity with skeletal muscle atrophy or weakness, and worsening of symptoms, particularly dyspnea. The molecular bases underlying the potential impact of exercise on the fitness and treatment outcome of patients with lung cancer are still elusive. Counteracting specific cancer cells’ acquired capabilities (hallmarks of cancer), together with preventing treatment‐induced adverse events, represent main candidate mechanisms. To date, the potential impact of physical activity and exercise in lung cancer remains to be fully appreciated, and no specific exercise guidelines for patients with lung cancer are available. In this article, we perform an in‐depth review of the evidence supporting physical activity and exercise in lung cancer and suggest that integrating this kind of intervention within the framework of a global, multidimensional approach, taking into account also nutritional and psychological aspects, might be the most effective strategy. Implications for Practice Although growing evidence supports the safety and efficacy of exercise in lung cancer, both after surgery and during and after medical treatments, most patients are insufficiently active or sedentary. Engaging in exercise programs is particularly arduous for patients with lung cancer, mainly because of a series of physical and psychosocial disease‐related barriers (including the smoking stigma). A continuous collaboration among oncologists and cancer exercise specialists is urgently needed in order to develop tailored programs based on patients’ needs, preferences, and physical and psychological status. In this regard, benefit of exercise appears to be potentially enhanced when administered as a multidimensional, comprehensive approach to patients’ well‐being.

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Section: Investigated Outcomes In Lung Cancermentioning

confidence: 98%

Section: Investigated Outcomes In Lung Cancermentioning

confidence: 99%

Section: Investigated Outcomes In Lung Cancermentioning

confidence: 99%

See 1 more Smart Citation

Physical Activity and Exercise in Lung Cancer Care: Will Promises Be Fulfilled?

Avancini

Sartori

Gkountakos³

et al. 2019

The Oncologist

124

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“…5,6 Several studies in recent years have confirmed that lung rehabilitation training such as respiratory function exercise and muscle exercise have a positive effect on the rehabilitation of lung function after NSCLC. 7,8 However, conventional lung rehabilitation training is monotonous and boring, and the patient's compliance is poor, making it difficult to persist after discharge. In addition, patients with malignant tumors often have a series of problems in negative emotions such as anxiety, depression, fear, social function, and emotional status, which are difficult to solve by relying solely on lung rehabilitation.…”

Section: Introductionmentioning

confidence: 99%

Effects of progressive Orff vocal therapy on BODE index and quality of life in patients with low lung function after non-small cell lung cancer surgery

Xue

et al. 2020

Tradit. Med. Mod. Med.

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Objective: To explore the effect of Orff vocal therapy on BODE index and quality of life of patients with low lung function after non-small cell lung cancer surgery. Methods: From March 2014 to March 2019, 231 patients with NSCLC postoperative (their pulmonary functions FEV1 [Formula: see text] of the expected value) in the Huashan Hospital, Fudan University were selected and randomly divided into observation groups and control group. On the basis of conventional treatment of NSCLC, the control group used lung rehabilitation training, and the observation group used the Orff music therapy. They carry out vocal and breath training step by step, using a combination of online and offline methods, 1[Formula: see text]h per day online interactive training, 2[Formula: see text]h of offline group vocal therapy once a week, continuous intervention for 12 months. The patient’s BODE index and FACT-L scores were monthly follow-up. Results: Compared with the control group, the BODE index and FACT-L scores improved more significantly in the vocal therapy group ([Formula: see text]). Especially in the FEV1pred, family/society module and functional status module, the improvement was most significant, compared with the control group ([Formula: see text]). And the loss of follow-up rate in the vocal therapy group was lower than that in the lung rehabilitation group ([Formula: see text]). Conclusion: Orff vocal therapy can improve the BODE index and quality of life of patients with low lung function after non-small cell lung cancer surgery, and its compliance and intervention effects are better than ordinary lung rehabilitation training.

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“…Despite positive physical benefits of VATS, recent studies emphasised that emotional, existential and social concerns of a lung cancer diagnosis appear to be a great challenge after surgery (Missel, Pedersen, Hendriksen, Tewes, & Adamsen, , ). Furthermore, surgery still may be associated with long‐term and late effects of the resection reported as a reduction of pulmonary capacity, cardiorespiratory capacity and decreased quality of life (Messaggi‐Sartor et al, ).…”

Section: Introductionmentioning

confidence: 99%

A sense of understanding and belonging when life is at stake—Operable lung cancer patients' lived experiences of participation in exercise

et al. 2019

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Objective To explore the lived experiences and social benefits among patients with operable Non‐small‐cell lung cancer who participated in an exercise intervention. Methods Eighteen patients enrolled in an exercise intervention at 2 weeks post‐surgery participated in qualitative interviews at three time points. A phenomenological hermeneutical approach comprised the epistemological stance inspired by Ricoeur's philosophy. Analysis and interpretation provided descriptions that captured the meaning of the patients' lived experiences. Results The exercise intervention was significant in terms of the patients' social capital, and the patients experienced themselves as part of a community. Patients gained access to resources that derived from human interaction in the exercise group, and their illness and treatment became easier to manage when shared with others in the same situation. The intervention helped to create a community for patients after lung cancer surgery, and the patients experienced a feeling of belonging and equality with the other participants. Conclusion The group‐based exercise intervention created opportunities for mutual understanding between patients, making illness and treatment easier to manage. The patients experienced support to reformulate their identity during the exercise intervention in their interaction with peers in the group.

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Combined aerobic exercise and high-intensity respiratory muscle training in patients surgically treated for non-small cell lung cancer: a pilot randomized clinical trial

Cited by 68 publications

References 29 publications

Physical Activity and Exercise in Lung Cancer Care: Will Promises Be Fulfilled?

Physical Activity and Exercise in Lung Cancer Care: Will Promises Be Fulfilled?

Effects of progressive Orff vocal therapy on BODE index and quality of life in patients with low lung function after non-small cell lung cancer surgery

A sense of understanding and belonging when life is at stake—Operable lung cancer patients' lived experiences of participation in exercise

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