Combined allergic rhinitis and asthma syndrome (CARAS)

Ferreira, Laércia Karla Diega Paiva; Ferreira, Larissa Adilis Maria Paiva; Monteiro, Talissa Mozzini; Bezerra, Grasiela Costa; Bernardo, Larissa Rodrigues; Piuvezam, Márcia Regina

doi:10.1016/j.intimp.2019.105718

Cited by 63 publications

(57 citation statements)

References 85 publications

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“…Combined allergic rhinitis and asthma syndrome is a new concept which means they share the same characteristics like the same etiological agents, inflammatory cell profiles and therapeutic treatment. 33 However, we surprisingly found that allergic rhinitis is a protective risk factor while asthma is a risk factor for COPD exacerbation. Our result was also consistent with Joo Kyung Kim’s study, previous history of pneumonia rather than allergic rhinitis is the risk factor for COPD exacerbation.…”

Section: Discussionmentioning

confidence: 74%

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Distribution of COPD Comorbidities and Creation of Acute Exacerbation Risk Score: Results from SCICP

Ge¹,

Liu²,

Gu³

et al. 2021

JIR

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Background: Chronic obstructive pulmonary disease (COPD) often coexists with multiple comorbidities which may have a significant impact on acute exacerbations of patients. At present, what kind of comorbidities affects acute exacerbations and how comorbidities lead to poor prognosis are still controversial. The purpose of our study is to determine the impact of comorbidities on COPD exacerbation and establish an acute exacerbation risk assessment system related to comorbidities. Methods: A total of 742 COPD patients participated in the Shanghai COPD Investigation on Comorbidity Program (SCICP, ChiCTR2000030911). Finally, the baseline information of 415 participants and one-year follow-up data were involved in the analysis. We collected hemogram indices, pulmonary function tests and acute exacerbation of COPD with regular medical follow-up. Q-type cluster analysis was used to determine the clusters of participants. Receiver operating characteristic (ROC) analysis was constructed to assess the ability of indicators in predicting acute exacerbations. Results: Almost 65% of the population we investigated had at least one comorbidity. The distribution and incidence of comorbidities differed between exacerbation group and nonexacerbation group. Three comorbidity clusters were identified: (1) respiratory, metabolic, immune and psychologic disease (non-severe cases); (2) cardiovascular and neoplastic disease (severe cases); (3) less comorbidity. Different sub-phenotypes of COPD patients showed significant distinction in health status. Anxiety (OR=5.936, P=0.001), angina (OR=10.155, P=0.025) and hypertension (OR=3.142, P=0.001) were found to be independent risk factors of exacerbation in a year. The novel risk score containing BODEx and four diseases showed great prognostic value of COPD exacerbation in developing sample. Conclusion:Our study detailed the major interaction between comorbidities and exacerbation in COPD. Noteworthily, a novel risk score using comprehensive index -BODEx -and comorbidity parameters can identify patients at high risk of acute exacerbation.

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Section: Discussionmentioning

confidence: 74%

“…Th2-driven inflammation response and Th2 cytokines (IL-4, IL-13) are established to be critical in both of them. 33 It is widely believed that allergic inflammation response exacerbates the illness. Daniel B. Jamieson’s research revealed that in individuals with COPD, allergic phenotype was more likely to have respiratory symptoms.…”

Section: Discussionmentioning

confidence: 99%

Distribution of COPD Comorbidities and Creation of Acute Exacerbation Risk Score: Results from SCICP

Ge¹,

Liu²,

Gu³

et al. 2021

JIR

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“…Çalışmamızda astımlı grupta gece yatmadan son 2 saat önceki beslenme sıklığı daha az olmasına rağmen burun akıntısı, burun tıkanıklığı ve horlama gibi şikayetler daha fazla saptandı. "Tek hava yolu, tek hastalık" kapsamında bir bütünün parçası olarak astımlı hastalarda bronşiyal aşırı duyarlılığa çoğunlukla üst solunum yollarındaki aşırı duyarlılığın da eşlik etmesi ve üst solunum yolu semptomlarına eğilim olması, ek olarak alerjik rinitin astım komorbiditesi olarak eşlik edebilme olasılığı astımlı çocuklarda bu semptomların daha fazla görülmesine neden olabilir (15,16). Gece yatmadan önceki beslenme sıklığının astımlı çocuklarda daha düşük olmasının en önemli sebebi astımlı hastalarımızın annelerine beslenme konusunda eğitim vermemizdir.…”

Section: <0001unclassified

Okul Öncesi̇ Astimli Çocuklarda Yatmadan Önceki̇ Beslenme: Üst Solunum Yolu Semptomlarini Ve Astim Kontrolünü Etki̇ler Mi̇?

Süleyman¹,

Yücel²,

Demirkale³

et al. 2021

jmed

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Objective: In this study, our aim was to investigate the effects of feeding habits such as the last feed before bedtime, feeding during sleep, bedtime, waking time and factors associated with the social environment on upper airway tract symptoms and asthma control. Material and Method:The study was conducted on children with preschool asthma and their age and sex matched healthy children. Results:The study group included 217 children, 103 of whom have asthma and 114 were (52.5%) healthy. The frequency of feeding in the last 2 hours before going to bed was 47.6% in children with asthma and 82.5% in healthy children (p<0,001). In children with asthma, there was a positive correlation between feeding within 0-2 hours before going to bed and hoarseness (r=0,429, p=0,001), snoring (r=0,430, p=0,001), rhinorrhea (r=0,429, p=0,001) and nasal congestion (r=0,469, p=0,001). In healthy children, the same positive correlation was detected with snoring (r=0,227, p=0,016) and the number of otitis (r=0,294, p=0,002). Caregivers other than mothers, the late awakening and the number of wake-ups during night were determined as risk factors for uncontrolled asthma. Conclusion:Not feeding in 0-2 hours before bedtime seems to be advisable for asthmatic preschool children since it can cause an increase in upper respiratory symptoms.

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“…It is a worldwide health problem causing disability in all age groups and in people with different socio-economics features. Allergic rhinitis is classified as a seasonal and perennial disease, and currently, it is known to present with either intermittent or persistent symptoms (3,4). Diagnosis is usually based on a typical history taking, as well as in vivo and in vitro tests.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Allergic Rhinitis in Children with Adenotonsillar Hypertrophy Referred to Imam Khomeini Hospital of Ahvaz from 2019 to 2020

Nikakhlagh

Norouzi

Saki

et al. 2021

Jundishapur J Chronic Dis Care

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Background: Allergic diseases are among the most common chronic conditions in pediatrics. Objectives: This study aimed to evaluate the relative frequency of allergic rhinitis (AR) in children with adenotonsillar hypertrophy. Methods: In this descriptive study, 175 patients with adenotonsillar hypertrophy referred to the Imam Khomeini hospital of Ahvaz from March 2019 to March 2020 were enrolled. Allergic rhinitis was diagnosed based on the Score for AR (SFAR) questionnaire. The questionnaire, including the expert-designed SFAR, has eight main components that evaluate eight quantitative features of AR, and each was designated with a specific weighted score based on previous clinical studies. The total score could vary from 0 to 16. Frequency and percentage were used to describe the data. The chi-square test and Fisher's exact test were used to analyze the data. Results: One hundred seventy-five patients with adenotonsillar hypertrophy in the age range of 1 to 17 years were studied. Ninety-one patients (52%) were male, and 84 patients (48%) were female. Based on the score obtained from the questionnaire, 146 patients (83.4%) had a score of less than seven, indicating susceptibility to AR. Twenty-nine patients (16.6%) had a score equal to or higher than 7, confirming the diagnosis of AR. The Chi-square test showed that AR was significantly associated with all the components of the questionnaire, except for cigarette smoking (P-value < 0.001). Conclusions: This study showed the strong association of AR with some demographic factors. Allergic rhinitis could potentially increase the risk of adenotonsillar hypertrophy in children.

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Combined allergic rhinitis and asthma syndrome (CARAS)

Cited by 63 publications

References 85 publications

Distribution of COPD Comorbidities and Creation of Acute Exacerbation Risk Score: Results from SCICP

Distribution of COPD Comorbidities and Creation of Acute Exacerbation Risk Score: Results from SCICP

Okul Öncesi̇ Astimli Çocuklarda Yatmadan Önceki̇ Beslenme: Üst Solunum Yolu Semptomlarini Ve Astim Kontrolünü Etki̇ler Mi̇?

Prevalence of Allergic Rhinitis in Children with Adenotonsillar Hypertrophy Referred to Imam Khomeini Hospital of Ahvaz from 2019 to 2020

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