2023
DOI: 10.3389/fimmu.2023.1142126
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Combined analysis of bulk and single-cell RNA sequencing reveals novel natural killer cell-related prognostic biomarkers for predicting immunotherapeutic response in hepatocellular carcinoma

Abstract: IntroductionNatural killer (NK) cells play an irreplaceable and important role as a subtype of innate immune cells in the contemporary setting of antitumor immunity.MethodsWe chose a total of 1,196 samples for this analysis from the public dataset’s six separate cohorts. To identify 42 NK cell marker genes, we first carried out a thorough study of single-cell RNA sequencing data from the GSE149614 cohort of hepatocellular carcinoma (HCC).ResultsUsing the NK cell marker genes in the TCGA cohort, we next created… Show more

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Cited by 4 publications
(2 citation statements)
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“…Quality control and cell screening were carried out on the GSE149614 dataset using the Seurat package [ 15 ] as reported by the previous study [ 16 ], yielding a total of 31,396 cells and 17 distinct subgroups for additional analysis. These distinct groupings were identified based on several marker genes (Figure S1).…”
Section: Methodsmentioning
confidence: 99%
“…Quality control and cell screening were carried out on the GSE149614 dataset using the Seurat package [ 15 ] as reported by the previous study [ 16 ], yielding a total of 31,396 cells and 17 distinct subgroups for additional analysis. These distinct groupings were identified based on several marker genes (Figure S1).…”
Section: Methodsmentioning
confidence: 99%
“…Lymphocytes constitute most immune cells in HCC, and studies indicate that abundant lymphocyte infiltration in HCC is associated with a better prognosis (12). Previous studies of lymphocyte infiltration primarily relied on the technique of genomics and transcriptomics, which required complicated examination and additional cost.…”
Section: Introductionmentioning
confidence: 99%