Combined Analysis of Expression of c-evbB-2, Ki-67 Antigen, and Tenascin Provides a Better Prognostic Indicator of Carcinoma of the Papilla of Vater

Vaidya, Pradeep; Yosida, Toshimichi; Sakakura, Teruyo; Yatani, Ryuichi; Noguchi, Takashi; Kawarada, Yoshifumi

doi:10.1097/00006676-199603000-00015

Cited by 14 publications

(4 citation statements)

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“…15 Annexin II is present in the cell cytoplasm in a monomeric form in which it forms a complex with calpactin I light chain (p11), a member of the S-100 family of EF hand proteins. 38,42,44 An- nexin II has been identified as a high-affinity receptor for ECM glycoproteins, including an alternatively spliced domain of tenascin-C. 33,34 Because this alternatively spliced domain promotes tumor cell migration, 33,34 we hypothesized that the role of annexin II overexpression in the spread of colorectal carcinoma may be mediated in part through the binding of tenascin-C. 55,56 Tetrameric annexin II [(Annexin II) 2 -(p11) 2 ] is localized to the cell membrane.…”

Section: Discussionmentioning

confidence: 99%

“…[32][33][34][35][36] Stromal tenascin-C overexpression has been demonstrated in malignant tumors of the skin, breast, salivary gland, lung, esophagus, pancreas, small intestine, and colon [36][37][38][39][40][41][42][43][44][45] and has been suggested to be a prognostic marker for a number of human carcinomas. 38,42,44 Tenascin-C has multiple isoforms as a result of alternative splicing. 26 Annexin II is a high affinity receptor for an alternatively spliced segment of tenascin-C, 33,34 and ligand binding promotes tumor cell migration.…”

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confidence: 99%

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Annexin II overexpression correlates with stromal tenascin-C overexpression

Emoto

Yamada

Sawada

et al. 2001

Cancer

150

122

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Annexin II overexpression correlates with stromal tenascin-C overexpression

Emoto

Yamada

Sawada

et al. 2001

Cancer

150

122

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“…With regard to the proliferation marker, MIB1, the results of our own investigation are compatible with those reported by Minimo et al [23] who, in a study published in 1996, described a strong correlation of the Ki-67 antigen expression rate with the progression of malignancy of ampullary lesions. Vaidya et al [24] observed a decrease in survival time with increasing Ki-67 positivity.…”

Section: Originalarbeitmentioning

confidence: 96%

The Adenoma-Carcinoma Sequence Applies to Epithelial Tumours of the Papilla of Vater

Kaiser¹,

Jurowich²,

Schönekäs³

et al. 2002

Z Gastroenterol

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Adenomas of the papilla of Vater are relatively rare tumours. They are of particular interest, not only because of their particular topography, but also because the adenoma-carcinoma sequence - accepted in the colorectum - has also been postulated to apply to the papilla of Vater. In fact, ampullary adenoma is often considered to be a precancerous lesion. To investigate this hypothesis, we reviewed the surgical specimens obtained during Whipple's procedures carried out to treat histologically confirmed carcinoma of the ampulla. A total of 37 surgical specimens obtained since January 1991 were reexamined for the presence of coexisting adenomatous structures. Such adenomatous residues were confirmed in 24/37 (65 %) cases. In 13/37 (35 %) cases, no residual adenoma was found. A comparison of the two groups revealed that detection of coexisting adenomatous structures decreased with increasing tumour progression. In similar manner, this also applied to the degree of malignancy: with increasing grade of malignancy the rate of detectable adenomatous structures decreased significantly. It may be assumed that these observations are due to the 'overgrowth' of preexisting adenomas by carcinomatous tissue. Further evidence is provided by the histological observation of transitional stages from adenoma with mild, moderate and severe cellular atypia to invasive carcinoma. These findings support the hypothesis of an adenoma-carcinoma sequence.

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“…Tenascin C concentrations have been associated with tumour recurrence and prognosis, although the findings are contradictory. [10][11][12][13][14][15] In laryngeal and hypopharyngeal cancers, the accumulation of tenascin in the blood vessels is an indicator of an unfavourable prognosis; it correlates with metastasis, early tumour recurrence, and a lethal outcome. 14 In breast cancer, the expression of tenascin C in the invasion border of the tumour is a predictor of local and distant recurrence.…”

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confidence: 99%

Tenascin C expression is upregulated in pancreatic cancer and correlates with differentiation

Juuti

Nordling²,

Louhimo³

et al. 2004

J Clin Pathol

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Background: Tenascin C is a large, hexameric, extracellular matrix protein that is present during embryonic development but essentially absent in adult tissues. It is involved in remodelling processes, such as wound healing and tumour development. Tissue expression of tenascin C correlates with prognosis in colorectal, cervical, and breast cancer and in carcinoma of the papilla of Vater. Aim: To study the expression of tenascin C in pancreatic cancer and to compare the staining results with the patients' clinicopathological data. Material and methods: Formalin fixed, paraffin wax embedded specimens from 146 patients with pancreatic adenocarcinoma were stained with an anti-tenascin C monoclonal antibody. Results: Tenascin C immunoreactivity was seen in most samples of pancreatic carcinoma: staining was weak in 72 (49%), moderate in 52 (36%), strong in 10 (7%), and negative in 12 (8%) samples. Tenascin C expression correlated with age (( 66 v . 66 years) and poor differentiation (grades 1-2 v 3). There was no correlation between tenascin C expression and survival, clinical stage, tumour size, nodal status, distant metastasis, tumour location, or sex. Conclusion: Tenascin C expression was increased in most pancreatic carcinomas, but contrary to the results in other cancers, it is not a prognostic factor in pancreatic cancer.

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Combined Analysis of Expression of c-evbB-2, Ki-67 Antigen, and Tenascin Provides a Better Prognostic Indicator of Carcinoma of the Papilla of Vater

Cited by 14 publications

References 0 publications

Annexin II overexpression correlates with stromal tenascin-C overexpression

Annexin II overexpression correlates with stromal tenascin-C overexpression

The Adenoma-Carcinoma Sequence Applies to Epithelial Tumours of the Papilla of Vater

Tenascin C expression is upregulated in pancreatic cancer and correlates with differentiation

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