Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma

Zhang, Kexin; Zhou, Jian; Wu, Tong; Tian, Qunyan; Wang, Wanchun; Zhong, Hua; Chen, Ziyuan; Xiao, Xilin; Wu, Gen Sheng

doi:10.18632/aging.204191

Cited by 4 publications

(3 citation statements)

References 48 publications

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“…Firstly, our results show that compared with nontumour tissues, the high expression of GINS2 in BLCA, BRCA, CHOL, COAD, ESCA, GBM, HNSC, KICH, KIRC, KIRP, LIHC, LUAD, LUSC, STAD, THCA, UCEC, CESC, READ, PCPG, ACC, DLBC, LAML, OV, SARC, SKCM, THYM, and UCS tissues indicates that GINS2 may be used as a tumour promoter in human cancer [ 22 ]. This is consistent with previous findings [ 20 , 23 , 24 ]. Secondly, combined with the results of the Cox analysis and Kaplan–Meier method, the high expression of GINS2 is associated with poor OS rate in ACC, KICH, KIRC, KIRP, LGG, LIHC, MESO, PAAD, PRAD, SARC, and SKCM and good OS rate in THCA and THYM.…”

Section: Discussionsupporting

confidence: 94%

Comprehensive Pan-Cancer Analysis of GINS2 for Human Tumour Prognosis and as an Immunological Biomarker

Meng

Jiang

Zhang

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. In recent years, more and more reports have shown that GINS complex subunit 2 (GINS2) plays an important role in the occurrence and progression of tumours. However, there is a lack of comprehensive and systematic research on its prognostic and immune effects in pan-cancer. Therefore, this study is aimed at investigating the prognostic value and immune-related role of GINS2 in human tumours and providing a comprehensive understanding of its carcinogenic mechanism in pan-cancer. Methods. We investigated different databases, including TIMER, TCGA, GTEX, CPTAC, GEPIA, and SangerBox. The study was carried out on the expression and prognosis of GINS2 in human tumours, immune infiltration and microenvironment, immune checkpoints, neoantigens, tumour mutational burden, microsatellite instability, mismatch repair (MMR) genes, methylation, cancer-associated fibroblasts (CAFs), and enrichment analysis of gene set. Results. GINS2 plays a potential carcinogenic role in various human tumours through mRNA and protein levels. It is highly expressed in most cancers, and its expression is significantly correlated with tumour prognosis. In addition, the expression of GINS2 is associated with immune microenvironment and immune infiltration, especially in brain lower-grade glioma, lung squamous cell carcinoma, TGCT, breast invasive carcinoma, and glioblastoma multiforme. At the same time, GINS2 is related to immune neoantigens and the expression profiles of immune checkpoint genes in pan-cancer. It also affects the expression of DNA MMR genes and methyltransferase in pan-cancer. Finally, the correlation between GINS2 and CAF abundance in most tumours was studied, and an enrichment analysis of GINS2 and its related proteins was also carried out. Conclusion. This is the first study on GINS2 as a prognostic and immune mechanism in pan-cancer. GINS2 may be a valuable prognostic immunological biomarker of pan-cancer. This paper provides a relatively comprehensive understanding on the correlation of GINS2 with pan-cancer.

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Section: Discussionsupporting

confidence: 94%

Comprehensive Pan-Cancer Analysis of GINS2 for Human Tumour Prognosis and as an Immunological Biomarker

Meng

Jiang

Zhang

et al. 2022

Computational and Mathematical Methods in Medicine

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“…In addition, the mRNA expression levels of the four GINS family members (GINS1, GINS2, GINS3, GINS4) were all higher in sarcoma tissue. An increased expression of GINS genes was associated with poor overall survival, disease-free survival, and relapse-free survival and could serve as prognostic biomarkers [ 40 ]. However, similar genetic studies specific to UESL are not yet available and require further research.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Undifferentiated Embryonal Sarcoma of the Liver in Children

Lin,

Wu,

Chen

et al. 2024

Cancers

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Undifferentiated embryonal sarcoma of the liver is a rare mesenchymal tumor with a highly malignant potential. It occurs almost exclusively in the pediatric population and typically has a poor outcome. Although previous studies have reported dismal prognoses, recent advances in combined treatment modalities, e.g., surgery and chemotherapy, have given cause for optimism. Even in those diseases not amenable to complete surgical resection or refractory diseases, other treatment modalities, such as liver transplant, have yielded promising results. This paper provides a review of the current treatment modalities for hepatic undifferentiated embryonal sarcoma in children.

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“…Tumor development is a complex process, involving numerous factors such as altered gene expression, gene mutations, changes in protein structure, and changes in the tumor immune microenvironment [1][2][3]. Cancer poses a significant danger to human life and health and has a significant impact on socio-economic progress.…”

Section: Introductionmentioning

confidence: 99%

Multi-omics analysis of the oncogenic role of optic atrophy 1 in human cancer

Wu,

Xu,

et al. 2023

Aging

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Objective: To investigate the prognostic significance of optic atrophy 1 ( OPA1 ) in pan-cancer and analyze the relationship between OPA1 and immune infiltration in cancer. Results: OPA1 exhibited high expression levels or mutations in various types of tumor cells, and its expression levels were significantly correlated with the survival rate of tumor patients. In different tumor tissues, there was a notable positive correlation between OPA1 expression levels and the infiltration of cancer-associated fibroblasts in the immune microenvironment. Additionally, OPA1 and its related genes were found to be involved in several crucial biological processes, including protein phosphorylation, protein import into the nucleus, and protein binding. Conclusion: OPA1 is highly expressed or mutated in numerous tumors and is strongly associated with protein phosphorylation, patient prognosis, and immune cell infiltration. OPA1 holds promise as a novel prognostic marker with potential clinical utility across various tumor types. Methods: We examined OPA1 expression in pan-cancer at both the gene and protein levels using various databases, including Tumor Immune Estimation Resource 2.0 (TIMER 2.0), Gene Expression Profiling Interactive Analysis (GEPIA2), UALCAN, and The Human Protein Atlas (HPA). We utilized the Kaplan-Meier plotter and GEPIA datasets to analyze the relationship between OPA1 expression levels and patient prognosis. Through the cBioPortal database, we detected OPA1 mutations in tumors and examined their relationship with patient prognosis. We employed the TIMER 2.0 database to explore the correlation between OPA1 expression levels in tumor tissue and the infiltration of cancer-associated fibroblasts in the immune microenvironment. Furthermore, we conducted a gene search associated with OPA1 and performed enrichment analysis to identify the main signaling pathways and biological processes linked to them.

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Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma

Cited by 4 publications

References 48 publications

Comprehensive Pan-Cancer Analysis of GINS2 for Human Tumour Prognosis and as an Immunological Biomarker

Comprehensive Pan-Cancer Analysis of GINS2 for Human Tumour Prognosis and as an Immunological Biomarker

Treatment of Undifferentiated Embryonal Sarcoma of the Liver in Children

Multi-omics analysis of the oncogenic role of optic atrophy 1 in human cancer

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