Combined Analysis of HLA Class II Eplet Mismatch and Tacrolimus Levels for the Prediction of De Novo Donor Specific Antibody Development in Kidney Transplant Recipients

Lee, Hyeyoung; Min, Ji Won; Kang, Hyunhye; Lee, Hanbi; Eum, Sang Hun; Park, Yohan; Yang, Chul-Woo; Chung, Byung Ha; Oh, Eun‐Jee

doi:10.3390/ijms23137357

Cited by 4 publications

(2 citation statements)

References 49 publications

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“…Eplet mismatch clearly has a role in risk stratification of transplant recipients during the post-operative period. Wiebe et al (105) demonstrated that patients with a lower eplet mismatch burden are better able to tolerate lower tacrolimus troughs without developing DSA, a finding that has been reproduced in multiple independent cohorts (106,107). As these studies reinforce, understanding of eplet mismatch burden will enable personalization of immunosuppression reduction after transplantation.…”

Section: Epletsmentioning

confidence: 94%

Progress in kidney transplantation: The role for systems immunology

et al. 2022

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The development of systems biology represents an immense breakthrough in our ability to perform translational research and deliver personalized and precision medicine. A multidisciplinary approach in combination with use of novel techniques allows for the extraction and analysis of vast quantities of data even from the volume and source limited samples that can be obtained from human subjects. Continued advances in microfluidics, scalability and affordability of sequencing technologies, and development of data analysis tools have made the application of a multi-omics, or systems, approach more accessible for use outside of specialized centers. The study of alloimmune and protective immune responses after solid organ transplant offers innumerable opportunities for a multi-omics approach, however, transplant immunology labs are only just beginning to adopt the systems methodology. In this review, we focus on advances in biological techniques and how they are improving our understanding of the immune system and its interactions, highlighting potential applications in transplant immunology. First, we describe the techniques that are available, with emphasis on major advances that allow for increased scalability. Then, we review initial applications in the field of transplantation with a focus on topics that are nearing clinical integration. Finally, we examine major barriers to adapting these methods and discuss potential future developments.

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Section: Epletsmentioning

confidence: 94%

Progress in kidney transplantation: The role for systems immunology

et al. 2022

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“…In parallel, it has been repeatedly demonstrated that the occurrence of antibodies against donor HLAs after transplantation (the so-called de novo donor-specific antibodies, or dnDSAs), particularly those against HLA class II, is associated with the development of chronic allograft dysfunction [ 14 ]. A recent study by Lee et al showed that HLA class II eplet mismatch was associated with dnDSAs, and combined analysis of eplet mismatch and tacrolimus levels may have prognostic value for the development of dnDSAs [ 15 ]. The mean number of HLA class II antigen mismatches was significantly higher in recipients who later developed HLA class II dnDSAs compared with recipients without dnDSAs.…”

mentioning

confidence: 99%