Combined analysis of HPV DNA, p16, p21 and p53 to predict prognosis in patients with stage IV hypopharyngeal carcinoma

Ernoux-Neufcoeur, Perle; Arafa, Mohammad; Decaestecker, Christine; Duray, Anaelle; Remmelink, Myriam; Leroy, Xavier; Herfs, Michaël; Somja, Joan; Depuydt, Christophe; Delvenne, Philippe; Saussez, Sven

doi:10.1007/s00432-010-0871-2

Cited by 36 publications

(52 citation statements)

References 25 publications

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“…The majority of the studies in the meta-analysis differed from the study by Ernoux-Neufcoeur et al, which reported an 82% HPV prevalence, as only 9% of the tumours overexpressed p16, suggesting that, in that study, only a limited number of tumours truly had an active HPV infection (19,21).…”

Section: Hpv In Hypopharyngeal Cancermentioning

confidence: 67%

“…Other studies reported an HPV prevalence of 0-82%, with a recent meta-analysis showing an average of 21.9% (18)(19)(20)(21)(22)(23)(24)(25)(26)(27). The majority of the studies in the meta-analysis differed from the study by Ernoux-Neufcoeur et al, which reported an 82% HPV prevalence, as only 9% of the tumours overexpressed p16, suggesting that, in that study, only a limited number of tumours truly had an active HPV infection (19,21).…”

Section: Hpv In Hypopharyngeal Cancermentioning

confidence: 68%

“…Accumulating reports describe the presence of HPV DNA in several cancers of unknown primary (CUP) in the head and neck region, as well as in a minority of hypopharyngeal cancers and other non-OPSCC locations (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). Notably, patients with HPV-positive tumours, particularly in CUP of the head and neck region and possibly also in hypopharyngeal cancer, tend to have a better clinical outcome compared with those with corresponding HPV-negative tumours, in whom HPV status may also have implications for diagnosis and therapy (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)27,28). However, this has not been investigated in the same detail for other cancer locations in the head and neck region, whereas reports usually compare survival between patients with HPV-positive and those with HPV-negative non-OPSCC.…”

Section: Introductionmentioning

confidence: 99%

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Human papillomavirus is a favourable prognostic factor in cancer of unknown primary in the head and neck region and in hypopharyngeal cancer

Sivars¹,

Bersani²,

Grün³

et al. 2016

Molecular and Clinical Oncology

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Abstract. Human papillomavirus (HPV), in addition to smoking and alcohol, is a cause of oropharyngeal squamous cell carcinoma (OPSCC), particularly of the tonsils and base of the tongue (TSCC and BOTSCC, respectively). Moreover, HPV-positive TSCC and BOTSCC are associated with a better outcome compared with their HPV-negative counterparts (80 vs. 40% 3-year disease-free survival rate, respectively) and their incidence has increased in several countries. Recently, accumulating evidence of HPV in a considerable proportion of cancers of unknown primary (CUP) in the head and neck region and in a small proportion of hypopharyngeal SCCs has been reported. Furthermore, HPV-positive tumours, particularly cases with HPV DNA positivity in combination with overexpression of p16, also tend to have a better clinical outcome compared with that of the corresponding HPV-negative tumours. This finding is particularly prominent in HPV-positive CUPs of the head and neck region, where the primary tumour likely originates from the oropharynx. Thus, the determination of HPV status and p16 expression may be of value for the diagnosis and treatment of CUP of the head and neck region and may also be of value for hypopharyngeal cancers in the future. However, for hypopharyngeal cancer as well as other non-OPSCCs, additional studies per subsite on the effect of HPV status on survival are required.

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Section: Hpv In Hypopharyngeal Cancermentioning

confidence: 67%

Section: Hpv In Hypopharyngeal Cancermentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Human papillomavirus is a favourable prognostic factor in cancer of unknown primary in the head and neck region and in hypopharyngeal cancer

Sivars¹,

Bersani²,

Grün³

et al. 2016

Molecular and Clinical Oncology

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“…The aim of this study was to determine the prevalence of human papillomavirus (HPV) in patients with laryngeal benign lesions (LBLs) and laryngeal squamous cell carcinomas (LSCCs) using a sensitive E6/E7 type-specific PCR. Paraffinembedded samples from LBL (n=39) and LSCC patients (n=67) were evaluated for the presence of HPV DNA by GP5 + /GP6 + consensus PCR and E6/E7 type-specific PCR for HPV types 6,11,16,18,31,33,35, 39, 45, 51, 52, 53, 56, 58, 59, 66 and 68. In LSCCs, immunohistochemical staining of p16, p53 and EGFR was also assessed.…”

mentioning

confidence: 99%

High incidence of high-risk HPV in benign and malignant lesions of the larynx

Duray

Descamps²,

Arafa³

et al. 2011

Int J Oncol

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Abstract. The aim of this study was to determine the prevalence of human papillomavirus (HPV) in patients with laryngeal benign lesions (LBLs) and laryngeal squamous cell carcinomas (LSCCs) using a sensitive E6/E7 type-specific PCR. Paraffinembedded samples from LBL (n=39) and LSCC patients (n=67) were evaluated for the presence of HPV DNA by GP5 + /GP6 + consensus PCR and E6/E7 type-specific PCR for HPV types 6,11,16,18,31,33,35, 39, 45, 51, 52, 53, 56, 58, 59, 66 and 68. In LSCCs, immunohistochemical staining of p16, p53 and EGFR was also assessed. The E6/E7 type-specific PCR showed that 44 out of 59 LSCC patients (i.e., 75%) had high-risk (hr) HPV types and that 27 out of 35 LBL patients (i.e., 77%) had hrHPV types. HPV-16 viral load was significantly higher in LSCC than in LBL patients (p<10 -6 ). The presence of hrHPV DNA did not correlate with the proportion of disease-free patients. Comparable levels of p16, p53 and EGFR expression were observed in the hrHPV + tumor group (100% p16 + , 56% p53 + and 97% EGFR + ) and in the HPV -or low-risk (lr) HPV + tumor group (92% p16 + , 66% p53 + and 100% EGFR + ). A very high prevalence of oncogenic HPV-16 was found in a series of benign and malignant laryngeal lesions. LSCC appears to be characterized by an active hrHPV infection. In LSCCs, the hrHPV + subgroup had a similar prognosis (in terms of risk of recurrence) as the HPV -subgroup.

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“…Among the types of this virus that have been identified, more than 80 have been characterized, and 40 types are able to infect the anogenital area (3) . The identification of HPV types is currently being applied in clinical practice as a prognostic predictor of cervical cancer in infected women (4) .…”

Section: Introductionmentioning

confidence: 99%

EpidEmiological FEaturEs oF papillomatosis causEd by thE human papillomavirus in WomEn attEnding thE basic hEalthcarE clinic in nova iguaçu county, statE oF rio dE JanEiro

Barbosa¹,

Mendes²,

Silva³

et al. 2012

J Bras Doenças Sex Transm

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Introduction: viral diseases have affected humans for thousands of years; however, viruses were only recently determined to be associated with human malignant neoplasias. The discovery of the relationship between cervical cancer and the human papillomavirus (HPV) has significant implications in the health care of women. Objective: the aim of this study was to use an epidemiological survey to investigate the variables that composed the profile of female patients with suspicion of cervical HPV infection who attended Nova Iguaçu General Hospital (Hospital Geral de Nova Iguaçu -HGNI) in the state of Rio de Janeiro. Methods: the patients attended Nova Iguaçu General Hospital from March 2009 to February 2010 and were interviewed using a pre-established questionnaire. Results: in total, 117 patients were interviewed. Based on the data that were supplied by the attending physicians, the average patient age was 34.5 years. The patients resided in different municipalities in the state of Rio de Janeiro, and 53 (44%) of the patients resided in Nova Iguaçu county. Overall, 60 patients (51%) reported four or more sexual partners, and 17 patients (15%) reported only one partner. A total of 105 women (90%) reported that they did not use condoms with their stable partners, and 9 women (10%) reported that they always used condoms with their partners. Conclusion: women with a mean age of 34.5 years who had four or more sexual partners may be at high risk for invasive carcinoma when persistent HPV infection, especially HPV type 16, is detected in them. We conclude that cervical cancer screening is essential in women aged 25 to 59 years. Keywords: epidemiology, diagnosis, HPV, STD RESUMO Introdução: as doenças virais têm afetado o homem há milhares de anos; porém, o conhecimento de vírus que promovem o desenvolvimento de neoplasias malignas humanas é bem recente. Foi de suma importância, para a saúde das mulheres, a descoberta da relação entre o câncer de colo uterino e o papilomavírus humano (HPV). Objetivo: o objetivo deste trabalho foi pesquisar, através de inquérito epidemiológico, as variáveis relacionadas ao perfil das pacientes com suspeitas de HPV de colo de útero atendidas no Hospital Geral de Nova Iguaçu, no estado do Rio de Janeiro. Métodos: as pacientes atendidas no Hospital Geral de Nova Iguaçu (HGNI) no período de março/2009 a fevereiro/2010 foram entrevistadas através de questionário preestabelecido. Resultados: ao todo, 117 pacientes foram entrevistadas. Baseando-se nos dados fornecidos pelo médico responsável, pode-se observar que a média de idade era de 34,5 anos, e que as pacientes eram originárias de diversos municípios do estado do Rio de Janeiro, sendo 53 (44%) do município de Nova Iguaçu. Quanto ao número de parceiros sexuais, 60 mulheres (51%) apresentaram quatro ou mais parceiros e 17 mulheres (15%) relataram relações com apenas um parceiro. 105 mulheres (90%) relataram não usar preservativo com o parceiro permanente e nove mulheres (10%) descreveram o uso contínuo do preservativo com seus respectiv...

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Combined analysis of HPV DNA, p16, p21 and p53 to predict prognosis in patients with stage IV hypopharyngeal carcinoma

Cited by 36 publications

References 25 publications

Human papillomavirus is a favourable prognostic factor in cancer of unknown primary in the head and neck region and in hypopharyngeal cancer

Human papillomavirus is a favourable prognostic factor in cancer of unknown primary in the head and neck region and in hypopharyngeal cancer

High incidence of high-risk HPV in benign and malignant lesions of the larynx

EpidEmiological FEaturEs oF papillomatosis causEd by thE human papillomavirus in WomEn attEnding thE basic hEalthcarE clinic in nova iguaçu county, statE oF rio dE JanEiro

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