Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour angiogenesis

Świtalska, Marta; Filip‐Psurska, Beata; Milczarek, Magdalena; Psurski, Mateusz; Moszyńska, Adrianna; Dąbrowska, Aleksandra; Gawrońska, Małgorzata; Krzymiński, Karol; Bagiński, Maciej; Bartoszewski, Rafał; Wietrzyk, Joanna

doi:10.1111/jcmm.17430

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…Similarly, Świtalska et al describe both above-mentioned parameters for the assessment of tumor perfusion. Higher WiR values are related to more vascularized tissues and indicate higher perfusion speed [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

In Vivo Contrast Imaging of Rat Heart with Carbon Dioxide Foam

Karalko

Keša

Jelínek³

et al. 2022

Sensors

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Widely used classical angiography with the use of iodine contrast agents is highly problematic, particularly in patients with diabetes mellitus, cardiac and pulmonary diseases, or degree III or IV renal insufficiency. Some patients may be susceptible to allergic reaction to the iodine contrast substance. The intravenous injection of a bolus of CO2 (negative contrast) is an alternative method, which is, however, currently only used for imaging blood vessels of the lower limbs. The aim of our project was to design and test on an animal model a methodology for injecting the CO2 foam which would minimize the possibility of embolization of the brain tissue and heart infarction, leading to their damage. This is important research for the further promotion of the use of CO2, which is increasingly important for endovascular diagnosis and treatment, because carbon-dioxide-related complications are extremely rare. CO2 foam was prepared by the rapid mixing in a 2:1 ratio of CO2 and fetal bovine serum (FBS)-enriched Dulbecco’s Modified Eagle Medium (DMEM). Freshly prepared CO2 foam was administered into the catheterized rat tail vein or cannulated rat abdominal aorta and inferior vena cava (IVC). CO2 foam was compared with commercially available microbubbles (lipid shell/gas core). The rat heart in its parasternal long axis was imaged in B-Mode and Non-linear Contrast Mode before/during and after the contrast administration. Samples of the brain, heart and lungs were collected and subjected to histological examination. The non-linear contrast imaging method enables the imaging of micron-sized gas microbubbles inside a rat heart. The significantly shorter lifetime of the prepared CO2 foam is a benefit for avoiding the local ischemia of tissues.

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Section: Discussionmentioning

confidence: 99%

In Vivo Contrast Imaging of Rat Heart with Carbon Dioxide Foam

Karalko

Keša

Jelínek³

et al. 2022

Sensors

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“…For example, sunitinib malate (Pfizer Sutent®) was identified as an oral multi‐kinase inhibitor preventing the growth, proliferation, and spread of cancers by targeting vascular endothelial growth factor receptor (VEGFR) and platelet‐derived growth factor receptor (PDGFR) (Raymond et al 2011). In our study, we identified triazoloacridone C‐1305, a microtubule stabilizing agent that also has topoisomerase II inhibitory activity, to also be a direct IRE1's RNase inhibitor (Kroliczewski et al 2020; Bartoszewska et al 2021; Switalska et al 2022). However, the wide range of other activities that many IRE1 targeting compounds have may increase the risk of off‐target effects, and thus this may limit their clinical application.…”

Section: Pharmacological Targeting Of Ire1 In Anticancer Approachesmentioning

confidence: 96%

Dual RNase activity of IRE1 as a target for anticancer therapies

Bartoszewska,

Sławski,

Collawn

et al. 2023

J. Cell Commun. Signal.

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The unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate survival and avoid apoptosis even during prolonged cell stress conditions. Here, we discuss different signaling pathways associated with UPR and focus specifically on one of the ER signaling pathways activated during UPR, inositol-requiring enzyme 1α (IRE1). The rationale is that the IRE1 pathway is associated with cell fate decisions and recognized as a promising target for cancer therapeutics. Here we discuss IRE1 inhibitors and how they might prove to be an effective cancer therapeutic. Graphical abstract

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