Combined antiretroviral therapy reduces hyperimmunoglobulinemia in HIV-1 infected children

Children, Italian Register for Hiv Infection in

doi:10.1097/01.aids.0000125985.94527.b2

Cited by 10 publications

(2 citation statements)

References 26 publications

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“…It was suggested that this could be due to reduction in viral replication by the drugs resulting in the improvement of health. A similar finding of reduced level of globulin fraction after initiation of antiretroviral therapy had also been earlier documented 19 . Elevation in globulin fraction is thus a characteristic of chronic inflammatory condition generally created by viral infection, and this could explain the observed increase in alpha-1 and beta globulin levels of HBV mono-infected subjects.…”

Section: Discussionsupporting

confidence: 80%

Serum protein concentration and amino acid profile of HIV/HBV co-infected subjects on HAART in Plateau State, Nigeria

Igwe¹,

Ewuga²,

Ujowundu³

et al. 2022

Afr H. Sci.

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Background: Human immunodeficiency virus (HIV) and hepatitis B virus (HBV) are currently two important blood-borne human pathogens of major public health concern with high prevalence rates in Africa. Objectives: The study assessed the impact of HIV and HBV mono- and co-infections on serum total protein, albumin, globulin fractions and plasma free amino acids concentrations. Methods: This was a cross-sectional study on adult (25 – 64 years old) patients on Highly Active Antiretroviral Therapy attending AIDS Preventive Initiative in Nigeria Centre, Jos University Teaching Hospital, Plateau State, Nigeria. It involved 80 subjects; 20 HIV/HBV co-infected, 20 each of HIV and HBV mono-infected controls, and 20 seronegative controls. Results: Signiﬁcant (p<0.05) increases in total protein and gamma globulin but a reduction in albumin concentrations were observed in the HIV/HBV co-infected group. Similarly, significant (p<0.05) increases in alpha-1 and alpha-2 globulin concentrations were observed in the mono- and co-infected groups compared to the seronegative control group. There were significant (p<0.05) increases in the glucogenic, aromatic and branched-chain amino acid concentrations of the HIV/HBV co-infected subjects. Conclusion: The study suggests prognostic importance of alpha and gamma globulin fractions of serum protein as well as amino acid profile in the management of HIV/HBV co-infection. Keywords: Total protein; albumin; globulin; amino acid; viral infection.

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Section: Discussionsupporting

confidence: 80%

Serum protein concentration and amino acid profile of HIV/HBV co-infected subjects on HAART in Plateau State, Nigeria

Igwe¹,

Ewuga²,

Ujowundu³

et al. 2022

Afr H. Sci.

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“…Hypergammaglobulinemia reflects a generalized HIV-1-driven polyclonal B-cell activation and was shown to be directly related to viremia and inversely related to CD4% [66]. After virologic suppression with HAART, CD4 + T-cell count increases, hypergammaglobulinemia decreases to normal levels, and an increase in the absolute CD19 + B-cell count has been observed [67–71].…”

Section: B-cells Compartment and Haartmentioning

confidence: 99%

Suboptimal Immune Reconstitution in Vertically HIV Infected Children: A View on How HIV Replication and Timing of HAART Initiation Can Impact on T and B-cell Compartment

Cotugno

Douagi

Rossi

et al. 2012

Clinical and Developmental Immunology

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Today, HIV-infected children who have access to treatment face a chronic rather than a progressive and fatal disease. As a result, new challenges are emerging in the field. Recent lines of evidence outline several factors that can differently affect the ability of the immune system to fully reconstitute and to mount specific immune responses in children receiving HAART. In this paper, we review the underlying mechanisms of immune reconstitution after HAART initiation among vertically HIV-infected children analyzing the possible causes of suboptimal responses.

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Timing of HAART defines the integrity of memory B cells and the longevity of humoral responses in HIV-1 vertically-infected children

Pensieroso

Cagigi

Palma³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

155

126

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Combined antiretroviral therapy reduces hyperimmunoglobulinemia in HIV-1 infected children

Abstract: Our data show that in HIV-1 infected children combined antiretroviral therapy leads to reduction of hyperimmunoglobulinemia which parallels restoration of CD4 T-lymphocyte percentage and viral load decrease, which it turn probably reflects improved B-lymphocyte functions.

Cited by 10 publications

References 26 publications

Serum protein concentration and amino acid profile of HIV/HBV co-infected subjects on HAART in Plateau State, Nigeria

Serum protein concentration and amino acid profile of HIV/HBV co-infected subjects on HAART in Plateau State, Nigeria

Suboptimal Immune Reconstitution in Vertically HIV Infected Children: A View on How HIV Replication and Timing of HAART Initiation Can Impact on T and B-cell Compartment

Timing of HAART defines the integrity of memory B cells and the longevity of humoral responses in HIV-1 vertically-infected children

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