Combined Antithrombotic Treatment With Aspirin and Clopidogrel for Patients With Capsular Warning Syndrome

Asıl, Talip; Ir, Nasf; Karaduman, Fatih; Çağlı, Bekir; Tuncel, Sedat Alpaslan

doi:10.1097/nrl.0b013e318247b9a5

Cited by 24 publications

(19 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There was no strong evidence for the efficacy of anticoagulant therapy in the acute phase of CWS. There had been case series suggesting that double antiplatelets (aspirin add clopidogrel) might be beneficial, similar to the effect seen in acute coronary syndromes [7,27,28]. In a case series including two patients with CWS, it was reported that following the start of double antiplatelets, there was no progression of symptoms.…”

Section: Discussionmentioning

confidence: 88%

“…Despite various treatments being available and used, it was unclear whether these treatments alter the natural course of the syndrome. Intravenous thrombolysis, double antiplatelet therapy, single antiplatelet therapy, anticoagulants, vasopressors had been used to treat patients with CWS [1,4,5,7,[9][10][11][12][13][20][21][22][23][24][25][26][27][28], it remains uncertain whether any of these therapies were able to change the progression of the syndrome. There was no strong evidence for the efficacy of anticoagulant therapy in the acute phase of CWS.…”

Section: Discussionmentioning

confidence: 99%

“…CWS was a rare clinical syndrome, which presented repeated stereotyped episodes of transient ischemic attacks (TIA), and increased the risk of permanent infarction, there had not been many large studies. Previous study showed that the incidence was about 1.5% among patients with TIAs [2].Therefore, the exact pathophysiological mechanism of CWS was not clear, and different treatments had been suggested, such as blood pressure control [4,5], anticoagulation [6], double antiplatelet therapy [7,8], single antiplatelet , and thrombolytic agent , but the best clinical management of these patients remain controversial.…”

Section: Introductionmentioning

confidence: 99%

“…dyslipidemia were the most common risk factors. The mean number of episodes before an irreversible neurological impairment or the symptoms completely disappeared was 5 times (3)(4)(5)(6)(7)(8)(9)(10)(11). 59 (81.94%) patients had acute infarction lesions on the diffusion weighted imaging (DWI).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Capsular Warning Syndrome: Clinical Analysis and Treatment

Xu²,

Wang

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Capsular warning syndrome (CWS) was a rare clinical syndrome, which was defined as recurrent transient lacunar syndromes. The mechanism and clinical management of CWS were not clear. The purpose of this study was to discuss the clinical characteristics, treatment and prognosis of the CWS. Methods: This was a multicenter retrospective study that involved three medical centers, we collected clinical data from patients with CWS between January 2013 and December 2018. We analyzed the clinical characteristics of the CWS. Patients with CWS were divided into two groups: rt-PA and no rt-PA groups. We analyzed the therapeutic effects and prognosis between different groups. Results: This study included 72 patients, 27 in rt-PA group, 45 in no rt-PA group, hypertension and dyslipidemia were the most common risk factors. The mean number of episodes before an irreversible neurological impairment or the symptoms completely disappeared was 5 times(3-11). 59 (81.94%) patients had acute infarction lesions on the diffusion weighted imaging (DWI). The most common infarct location was the internal capsule (76.38%,55), followed by the thalamus and pons. The difference in therapeutic effects between rt-PA, single and double antiplatelet groups was not significant(P>0.05). A good prognosis was observed in 61 (84.72%) patients at 3-month, 23 (23/27, 85.19%) patients in rt-PA group and 38 (38/45,84.44%) patients in no rt-PA group(P>0.05). After 3 months of follow-up, 2 patients had recurrent ischemic stroke. Conclusions: The most effective treatment of CWS remains unclear. Despite the high incidence of infarction in CWS patients, more than 80% patients had favorable functional prognosis

show abstract

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Capsular Warning Syndrome: Clinical Analysis and Treatment

Xu²,

Wang

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Kapsüler uyarı sendromunda da iskemik olay riskinin kanama riskinden fazla olması nedeniyle bu tedavinin kapsüler uyarı sendromlu vakalarda da uygun olabileceği düşünülmüştür. Asil ve arkadaşları kapsüler uyarı sendromu tanısı konan 2 vakayı 300 mg klopidogrel ve aspirin ile tedavi etmiş ve olumlu sonuçlar bildirmişlerdir (8). Bu tedaviden fayda gören birçok vaka bildirilmiştir.…”

Section: Olguunclassified

A stroke form fluctuating in acute stroke: Capsular warning syndrome

Bostan¹,

Aykaç²,

Akarsu³

et al. 2018

TÃ¼rk Beyin Damar Hast Derg

View full text Add to dashboard Cite

ÖZETKapsüler uyarı sendromu, öyküsü, kliniği ve artmış tekrarlayan inme riski nedeniyle önemli bir sendromdur. Patofizyolojisi anlaşılamadığı için tedavi yaklaşımı üzerinde bir fikir birliği bulunmamaktadır. Antiagregan, antikoagülan ve trombolitik tedavilere rağmen klinik ilerleyebilir. Kapsüler uyarı sendromu tanısı ile izlediğimiz üç vakayı klinik prezentasyonu, radyolojik bulguları ve tamamlanmış bir inmeyi engellemenin zor olableceğini tartışmak amacıyla sunmayı amaçladık. Anahtar Sözcükler: Akut inme, fluktuasyon, kapsüler uyarı sendromu. A STROKE FORM FLUCTUATING IN ACUTE STROKE: CAPSULAR WARNING SYNDROME ABSTRACTCapsular warning syndrome is an important clinical entity because of its typical story, presentation and increased risk of symptom recurrence recurrence. Since the pathophysiology of this syndrome has not be fully understood, there is no consensus on the treatment approach. Furthermore, clinical deterioration may occur despite antiplatelet, anticoagulant or trombolytic treatments. We aimed to present three cases with capsular warning syndrome to discuss their clinical presentations, radiological findings and to underline that prevention of its progression to a completed stroke may be difficult.

show abstract

Antithrombotic Therapy for Treatment of Acute Ischemic Stroke

Adams¹,

Davis²

2016

Stroke

View full text Add to dashboard Cite

Combined Antithrombotic Treatment With Aspirin and Clopidogrel for Patients With Capsular Warning Syndrome

Cited by 24 publications

References 6 publications

Capsular Warning Syndrome: Clinical Analysis and Treatment

Capsular Warning Syndrome: Clinical Analysis and Treatment

A stroke form fluctuating in acute stroke: Capsular warning syndrome

Antithrombotic Therapy for Treatment of Acute Ischemic Stroke

Contact Info

Product

Resources

About