Combined approaches identify known and novel genes associated with sheep litter size and non‐seasonal breeding

Lin, Tao; Wang, Xiangyu; Zhong, Yingjie; Liu, Qiuyue; Xia, Qing; Chen, Si; He, Xiaoyun; Di, Ran

doi:10.1111/age.13138

Cited by 6 publications

(2 citation statements)

References 84 publications

(155 reference statements)

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“…The same selection targets have been described in chicken [ 62 ]. Previous studies have established a pivotal role for TSHR in metabolic regulation and photoperiod control during reproduction in animals, such as sheep [ 63 ], herrings [ 64 ], geese [ 65 ], chickens [ 66 ], and rabbits [ 67 ]. In addition, an SNP in the TSHR gene resulted in an aspartic acid-to-alanine substitution, and it was conserved among most of the other species.…”

Section: Discussionmentioning

confidence: 99%

Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation

Jin,

Wang,

Liu

et al. 2024

Genet Sel Evol

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Background Chinese indigenous sheep are valuable resources with unique features and characteristics. They are distributed across regions with different climates in mainland China; however, few reports have analyzed the environmental adaptability of sheep based on their genome. We examined the variants and signatures of selection involved in adaptation to extreme humidity, altitude, and temperature conditions in 173 sheep genomes from 41 phenotypically and geographically representative Chinese indigenous sheep breeds to characterize the genetic basis underlying environmental adaptation in these populations. Results Based on the analysis of population structure, we inferred that Chinese indigenous sheep are divided into four groups: Kazakh (KAZ), Mongolian (MON), Tibetan (TIB), and Yunnan (YUN). We also detected a set of candidate genes that are relevant to adaptation to extreme environmental conditions, such as drought-prone regions (TBXT, TG, and HOXA1), high-altitude regions (DYSF, EPAS1, JAZF1, PDGFD, and NF1) and warm-temperature regions (TSHR, ABCD4, and TEX11). Among all these candidate genes, eight ABCD4, CNTN4, DOCK10, LOC105608545, LOC121816479, SEM3A, SVIL, and TSHR overlap between extreme environmental conditions. The TSHR gene shows a strong signature for positive selection in the warm-temperature group and harbors a single nucleotide polymorphism (SNP) missense mutation located between positions 90,600,001 and 90,650,001 on chromosome 7, which leads to a change in the protein structure of TSHR and influences its stability. Conclusions Analysis of the signatures of selection uncovered genes that are likely related to environmental adaptation and a SNP missense mutation in the TSHR gene that affects the protein structure and stability. It also provides information on the evolution of the phylogeographic structure of Chinese indigenous sheep populations. These results provide important genetic resources for future breeding studies and new perspectives on how animals can adapt to climate change.

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Section: Discussionmentioning

confidence: 99%

Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation

Jin,

Wang,

Liu

et al. 2024

Genet Sel Evol

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“…Sheep breeding is an important branch of livestock production. Sheep provide valuable raw materials such as sheepskin and wool for the textile industry, in addition to being a source of mutton, fat, and milk-commodities that enjoy high demand among the global population [1]. Over the course of more than 10,000 years, humans have engaged in the breeding of sheep [2].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Sheep MAST4 Gene Variants and Their Associations with Litter Size

Akhmet,

Zhu,

Song

et al. 2024

Animals

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The economic efficiency of sheep breeding can be improved by enhancing sheep productivity. A recent genome-wide association study (GWAS) unveiled the potential impact of the MAST4 gene on prolificacy traits in Australian White sheep (AUW)). Herein, whole-genome sequencing (WGS) data from 26 different sheep breeds worldwide (n = 1507), including diverse meat, wool, milk, or dual-purpose sheep breed types from China, Europe, and Africa, were used. Moreover, polymerase chain reaction (PCR) genotyping of the MAST4 gene polymorphisms in (n = 566) Australian white sheep (AUW) was performed. The 3 identified polymorphisms were not homogeneously distributed across the 26 examined sheep breeds. Findings revealed prevalent polymorphisms (P3-ins-29 bp and P6-del-21 bp) with varying frequencies (0.02 to 0.97) across 26 breeds, while P5-del-24 bp was presented in 24 out of 26 breeds. Interestingly, the frequency of the P3-ins-29 bp variant was markedly higher in Chinese meat or dual-purpose sheep breeds, while the other two variants also showed moderate frequencies in meat breeds. Notably, association analysis indicated that all InDels were associated with AUW sheep litter size (p < 0.05). These results suggest that these InDels within the MAST4 gene could be useful in marker-assisted selection in sheep breeding.

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A review on candidate genes associated with sheep fertility traits: Implications for genetic improvement of indigenous sheep breeds in developing countries

Getaneh,

Taye,

Alemayehu

et al. 2024

Ecological Genetics and Genomics

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Combined approaches identify known and novel genes associated with sheep litter size and non‐seasonal breeding

Cited by 6 publications

References 84 publications

Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation

Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation

Exploring the Sheep MAST4 Gene Variants and Their Associations with Litter Size

A review on candidate genes associated with sheep fertility traits: Implications for genetic improvement of indigenous sheep breeds in developing countries

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