Combined assessment of polymorphisms in theLHCGRandFSHRgenes predict chance of pregnancy afterin vitrofertilization

Lindgren, Ida; Bååth, Maria; Uvebrant, Kristina; Dejmek, Annika; Kjær, Lasse; Hénic, Emir; Bungum, Mona; Bungum, Leif; Cilio, Corrado; Leijonhufvud, Irene; Skouby, Sven O.; Andersen, Claus Yding; Giwercman, Yvonne Lundberg

doi:10.1093/humrep/dev342

Cited by 58 publications

(56 citation statements)

References 26 publications

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“…These findings are in contrast with those of the previous reports, indicating no association between this variant and the development of OHSS (Kerkela et al, ; Santos‐Ribeiro et al, ). However, Lindgren et al () have recently stated that women carrying A/A in LHCGR rs2293275 need lower doses of exogenous FSH for an adequate response. Taking into account our findings on the higher prevalence of the G/G genotype in OHSS patients, the data may attenuate the hypothesis asserting that A‐allele in LHCGR rs2293275 may enhance the sensitivity of the receptor to the hormone (Lindgren et al, ; Piersma et al, ).…”

Section: Discussionmentioning

confidence: 99%

The implication of single‐nucleotide polymorphisms in ovarian hyperstimulation syndrome

Ghaderian

Akbarzadeh

Mohajerani

et al. 2019

Molecular Reproduction Devel

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Ovarian hyperstimulation syndrome (OHSS) is an undesirable complication in the course of ovarian stimulation. This kind of stimulation is aimed at acquiring a sufficient number of high‐quality oocytes in in vitro fertilization (IVF). Whereas the predisposition to OHSS could be impacted by genetic polymorphisms in susceptible genes, the present study has been jointly conducted with an Iranian cohort to scrutinize its relevant implication. Genomic DNA was extracted from blood samples of patients with a normal ovarian response (NOR) or with OHSS. Samples were analyzed to detect polymorphisms MTHFR rs1801131, MTHFR rs1801133, AMHR2 rs2002555, LHCGR rs2293275, PGR rs10895068, and SERPINE1 rs1799889. Variations of MTHFR, AMHR2, LHCGR, and PGR genes were significantly associated with the developing OHSS. After correction for multiple analysis, this difference was not evident for PGR genotypes. The polymorphic alleles of MTHFR (rs1801131 C‐allele and rs1801133 T‐allele), AMHR2 (rs2002555 G‐allele), and LHCGR (rs2293275 G‐allele) were significantly more prevalent among patients with OHSS compared to those in the NOR group. In contrast, the minor allele of PGR single‐nucleotide polymorphism (SNP) (rs10895068, A‐allele) was more prominent among patients with a NOR than those with OHSS. No significant difference was observed in genotypes or alleles of SERPINE1 rs1799889. The observations indicated that the minor alleles of MTHFR, AMHR2, and LHCGR genes could be considered an independent risk factor in susceptibility to OHSS. Nevertheless, polymorphic allele in the PGR rs10895068 SNP contributes to preventing OHSS occurrence. Therefore, it can be argued that these genes have a significant impact on OHSS.

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Section: Discussionmentioning

confidence: 99%

The implication of single‐nucleotide polymorphisms in ovarian hyperstimulation syndrome

Ghaderian

Akbarzadeh

Mohajerani

et al. 2019

Molecular Reproduction Devel

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“…CYP17 polymorphisms also have been associated with the need for menopausal hormone replacement, with varying frequencies amongst racial groups, further suggesting differential propensities for steroid pathway functionality based on the frequencies of these polymorphisms (Feigelson, 1999). Polymorphisms of the FSH and LH receptors have been shown to predict assisted reproduction technique outcomes and determine the amount of gonadotrophin needed for assisted reproduction technique stimulation (Lazaros, 2013; Lasik-Podar 2015; Lindgren 2016). Polymorphisms in aromatase have been associated with differences in oestradiol and follicle response to ovarian stimulation (Lazaros, 2013).…”

Section: Discussionmentioning

confidence: 99%

Does elevated progesterone on day of oocyte maturation play a role in the racial disparities in IVF outcomes?

Hill

Royster

Taneja

et al. 2017

Reproductive BioMedicine Online

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The aim of this study was to evaluate if premature progesterone elevation on the last day of assisted reproduction technique stimulation contributes to racial disparities. A total of 3289 assisted reproduction technique cycles were evaluated in Latino, Asian, African American, and white women. Live birth was more likely in white women (42.6%) compared with Asian (34.8%) and African American women (36.3%), but was similar to Latino women (40.7%). In all racial groups, progesterone was negatively associated with live birth and the negative effect of progesterone persisted when adjusting for confounders. Although the effect of elevated progesterone was similar in all racial groups, the prevalence of elevated progesterone differed. P > 1.5 ng/ml occurred in only 10.6% of cycles in white women compared with 18.0% in Latino and 20.2% in Asian women. P > 2 ng/ml occurred in only 2.3% of cycles in white women compared with 6.3% in Latino, 5.9% in Asian and 4.4% in African American women. The increased prevalence of premature elevated progesterone persisted when controlling for IVF stimulation parameters. In conclusion, premature progesterone elevation had a negative effect on live birth in all racial groups studied. The prevalence of elevated progesterone was higher in racial minorities.

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“…Even those patients who were homozygous for the G/G variant revealed a higher number of mature oocytes than the patients homozygous for the A/A variant [10]. Regarding the effect of the c.2039 A>G polymorphism on pregnancy, the conclusions of published studies [7,13,24] are highly conflicting. Indeed, in one study [7], the G/G variant was associated with a lower clinical pregnancy rate, whereas in the paper by Klinkert et al [13], the A/A variant correlated to lower implantation and pregnancy rates than the G/G variant.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, in one study [7], the G/G variant was associated with a lower clinical pregnancy rate, whereas in the paper by Klinkert et al [13], the A/A variant correlated to lower implantation and pregnancy rates than the G/G variant. In the most recent study [24], the c.2039 A > G polymorphism was beneficial for pregnancy outcome only if combined with the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) variant Asn312Ser. Moreover, a recent meta-analysis failed to demonstrate a correlation between the G/G variant and the clinical pregnancy rate [25].…”

Section: Introductionmentioning

confidence: 99%

The carriers of the A/G-G/G allelic combination of the c.2039 A>G and c.-29 G>A FSH receptor polymorphisms retrieve the highest number of oocytes in IVF/ICSI cycles

Allegra

Marino

Raimondo

et al. 2016

J Assist Reprod Genet

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Purpose The objective of this study was the elucidation of the possible role of the single-nucleotide polymorphisms (SNP) at position -29 and 2039 of the FSH receptor gene (FSHR) as independent predictive markers of ovarian response. Indeed, the tailoring of reproductive treatments is crucial for both maximizing the success of IVF patients and obtaining a reduction in hypo-or hyper-response rates. Methods This prospective, observational study analyzed the association of -29 and 2039 FSHR polymorphisms with the number of retrieved oocytes in 140 patients attending an IVF/ ICSI cycle for severe male factors (≤5,000,000 spermatozoa/ mL) or tubal factors at the ANDROS Day

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Combined assessment of polymorphisms in theLHCGRandFSHRgenes predict chance of pregnancy afterin vitrofertilization

Abstract: This work was supported by Interreg IV A, EU (grant 167158) and ALF governments grant (F2014/354). Merck-Serono (Darmstadt, Germany) supported the enrollment of the subjects. The authors declare no conflict of interest.

Cited by 58 publications

References 26 publications

The implication of single‐nucleotide polymorphisms in ovarian hyperstimulation syndrome

The implication of single‐nucleotide polymorphisms in ovarian hyperstimulation syndrome

Does elevated progesterone on day of oocyte maturation play a role in the racial disparities in IVF outcomes?

The carriers of the A/G-G/G allelic combination of the c.2039 A>G and c.-29 G>A FSH receptor polymorphisms retrieve the highest number of oocytes in IVF/ICSI cycles

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