Combined biolistic and cell penetrating peptide delivery for the development of scalable intradermal DNA vaccines

So, Roizza Beth; Li, Gang; Brentville, Victoria; Daly, Janet M.; Dixon, James E.

doi:10.1016/j.jconrel.2024.01.031

Journal of Controlled Release

2024

DOI: 10.1016/j.jconrel.2024.01.031

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Combined biolistic and cell penetrating peptide delivery for the development of scalable intradermal DNA vaccines

Roizza Beth So,

Gang Li,

Victoria Brentville

et al.

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Cited by 5 publications

References 39 publications

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Covalent conjugation and non-covalent complexation strategies for intracellular delivery of proteins using cell-penetrating peptides

Behzadipour,

Hemmati

2024

Biomedicine & Pharmacotherapy

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Covalent conjugation and non-covalent complexation strategies for intracellular delivery of proteins using cell-penetrating peptides

Behzadipour,

Hemmati

2024

Biomedicine & Pharmacotherapy

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A miR-activated hydrogel for the delivery of a pro-chondrogenic microRNA-221 inhibitor as a minimally invasive therapeutic approach for articular cartilage repair

An,

Intini,

O'Shea

et al. 2025

Materials Today Bio

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New insights for the development of efficient DNA vaccines

Berger,

Zeyn,

Wagner

et al. 2024

Microbial Biotechnology

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Despite the great potential of DNA vaccines for a broad range of applications, ranging from prevention of infections, over treatment of autoimmune and allergic diseases to cancer immunotherapies, the implementation of such therapies for clinical treatment is far behind the expectations up to now. The main reason is the poor immunogenicity of DNA vaccines in humans. Consequently, the improvement of the performance of DNA vaccines in vivo is required. This mini‐review provides an overview of the current state of DNA vaccines and the various strategies to enhance the immunogenic potential of DNA vaccines, including (i) the optimization of the DNA construct itself regarding size, nuclear transfer and transcriptional regulation; (ii) the use of appropriate adjuvants; and (iii) improved delivery, for example, by careful choice of the administration route, physical methods such as electroporation and nanomaterials that may allow cell type‐specific targeting. Moreover, combining nanoformulated DNA vaccines with other immunotherapies and prime‐boost strategies may help to enhance success of treatment.

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Combined biolistic and cell penetrating peptide delivery for the development of scalable intradermal DNA vaccines

Cited by 5 publications

References 39 publications

Covalent conjugation and non-covalent complexation strategies for intracellular delivery of proteins using cell-penetrating peptides

Covalent conjugation and non-covalent complexation strategies for intracellular delivery of proteins using cell-penetrating peptides

A miR-activated hydrogel for the delivery of a pro-chondrogenic microRNA-221 inhibitor as a minimally invasive therapeutic approach for articular cartilage repair

New insights for the development of efficient DNA vaccines

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