Combined biological effects of silver nanoparticles and heavy metals in different target cell lines

Xue, Wei; Xu, An; Yun, Liu

doi:10.1007/s11356-021-16395-9

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…Anthropogenic activities contribute significantly to ecosystem pollution, a global challenge, with heavy metals (HMs) and nanoparticles (NPs) emerging as key pollutants [2,3]. Research on the interaction between HMs/NPs and ciliated protists is limited [29,31,36,41,57], especially compared to studies on other organisms [37,[58][59][60][61][62][63][64]. Cell biomass plays a pivotal role in bioassay treatments, modifying pollutant bioavailability and enhancing data accu-racy [65].…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity and Antioxidant Defences in Euplotes aediculatus Exposed to Single and Binary Mixtures of Heavy Metals and Nanoparticles

Varatharajan,

Calisi,

Kumar

et al. 2024

Applied Sciences

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The aim of this study was to analyse the cytotoxicity of heavy metals (HMs) and nanoparticles (NPs) on populations of the ciliated protist Euplotes aediculatus. We used ecotoxicological tests, antioxidant assays, and the MixTOX tool in Microsoft® Excel to evaluate the toxic effect of HMs and NPs in single and binary mixtures on E. aediculatus and to detect the type of interaction between them. Based on our results, the order of toxicity was Cu > Cd >> Zn (1 h and 24 h) for HMs and ZnO > CuO >> TiO2 >> SiO2 (1 h) and CuO > ZnO >> TiO2 >> SiO2 (24 h) for NPs. The interaction between metals in binary mixtures was predominantly synergistic at low doses and antagonistic at high doses. The type of interaction depende on the metals present and their respective concentrations. Furthermore, both HMs and NPs were shown to trigger effective antioxidant responses in E. aediculatus. Our research highlights the importance of considering the combined effects of HMs and NP exposure and their potency in risk assessment.

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity and Antioxidant Defences in Euplotes aediculatus Exposed to Single and Binary Mixtures of Heavy Metals and Nanoparticles

Varatharajan,

Calisi,

Kumar

et al. 2024

Applied Sciences

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show abstract

“…44,45 Nonetheless, metallodrugs share toxicity, bioaccumulation, and long-term in vivo stability deficiencies. 46,47 Among the most widely utilized metallodrugs are the Ag(I)-based compounds, such as silver sulfadiazine (silvadene, silverex, silvazine, SSD, thermazene), which are applied as a cream formulation to prevent and treat infections. 48 However, the toxicity and bioaccumulation of Ag(I) limit its broad use as a metallodrug.…”

Section: ■ Introductionmentioning

confidence: 99%

One-Year Water-Stable and Porous Bi(III) Halide Semiconductor with Broad-Spectrum Antibacterial Performance

Azmy,

Zhao,

Angeli

et al. 2023

ACS Appl. Mater. Interfaces

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The released micro/nano-plastics from plastic containers amplified the toxic response of disinfection by-products in human cells

Li,

Wang,

Zhou

et al. 2024

Food Chemistry

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Combined biological effects of silver nanoparticles and heavy metals in different target cell lines

Cited by 4 publications

References 36 publications

Cytotoxicity and Antioxidant Defences in Euplotes aediculatus Exposed to Single and Binary Mixtures of Heavy Metals and Nanoparticles

Cytotoxicity and Antioxidant Defences in Euplotes aediculatus Exposed to Single and Binary Mixtures of Heavy Metals and Nanoparticles

One-Year Water-Stable and Porous Bi(III) Halide Semiconductor with Broad-Spectrum Antibacterial Performance

The released micro/nano-plastics from plastic containers amplified the toxic response of disinfection by-products in human cells

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